ID H3D8A8_TETNG Unreviewed; 1810 AA.
AC H3D8A8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Laminin subunit beta-4 {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000016749.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000016749.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 99883.ENSTNIP00000016749; -.
DR Ensembl; ENSTNIT00000016963.1; ENSTNIP00000016749.1; ENSTNIG00000013747.1.
DR GeneTree; ENSGT00940000165244; -.
DR InParanoid; H3D8A8; -.
DR OMA; RRCSCHP; -.
DR TreeFam; TF312903; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 13.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 13.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 11.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 27..266
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 267..333
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 334..396
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 397..448
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 449..497
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 537..827
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 833..880
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 881..926
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 927..974
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1034..1085
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1086..1142
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1143..1190
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1191..1240
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT REGION 623..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1328..1355
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1487..1525
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1569..1610
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1694..1797
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 299..308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 364..373
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 419..428
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 469..478
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 481..495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 833..845
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 835..852
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 854..863
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 881..893
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 883..900
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 902..911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 946..955
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 958..972
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1058..1067
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1115..1124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1143..1155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1145..1162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1164..1173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1191..1203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1193..1210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1212..1221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1224..1238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1810 AA; 200653 MW; D53F283F96A8683B CRC64;
MLLIRLFLSL AHLQDLQDLQ DLQDHCPDGF CNPSLGDLMV GRASQLSASS TCGLDGPENY
CIIGYLEEEQ KCFTCDSRLP YNRYSNPNSH LIENVITTFE PERKLKWWQS ENGVHRVSIR
LDLETVFQFS HLVLKFKSFR PAAMLVERSK DFGQTWKVFR YFAEDCLLHF PSVPNELANS
IDDVVCDSRY SGSEPSTDGE VVLKALDPVF EIEDPYAYNI QDLITVTNIR INFTRLFTLG
DTLLRKRRNP QDKYYYALYD MVVRGSCFCN GHASQCTPVD QGRGDTFSQP GMVHGRCVCL
HNTAGENCER CADFHHDSPW RPGGQKAADV CRRCNCHGHS ESCHFDLARF EATGGVSGGM
CDNCRHGRTG PQCEHCQAKF YQDPQRARDH PQACIRCDCD LAGSKGGGLC DPLTGQCLCK
DNTEGQRCDR CKYGFFNLQP DDPNGCQECR CHVSGTVGSC DPVTGGCDCD PLAVGPLCDR
CLPGFWGLGN SLFRCSPCDC DLGGAQSTQC SPEEGQCRCL PNMVGRRCSD PAPGYFLPSL
DYFLYEAELA VPLHGGASPS TTDPPSSPLV RNKHKYALNM RAVPHRQRLN LGISPNCEQY
YRQQGYDFKL SNGRIVLVRR TARSARRRRQ EQRGSIPLEP GHPLQIIPRQ RTGGQPVTWT
GQGLVRVQDG AGLRFIVDNL PSSMDYQLVI RYEPEAPSDW DARVEITPVS LGDGRCASEP
TGRKALLLPG DSRAAVLDAP VCLNGGGRYF VDVVFDKQPD GTPSSPLLVD SMGLIPRIES
VQDFCSESDI DSFRRFRCVG LAAELSPQES LPESCEGLIS SMSARINNGA VACRCNAVGA
LGPSCSKLGG VCDCKPNVIG RCCDACAPMT FGFGPDGCEA CDCDPRGATS ELCDQVRGQC
SCRLEVTGRR CDHCRTGYWG FPLCRPCQCN GLSEECDPHT GECWNCRQHA QGPNCDRCEE
GYYGDPVSRQ PCEPCLCPDI QGSGRFFATS CHHEPQSLGL TCACREGHEG PSCDRCSPGY
YGNLALPGAS CELCLCNNNI DLDDRNACDG VTGECLRCLH NTMGPQCQDC KPGYYGNALE
RDCKECSCDR RGTKVTQCPL GSPCFCDPST GQCPCRKGVV GVLCDECEDG YWNMDGASGC
QPCSCDPANS LSYVCDKVTG QCPCLTEFGG QQCDECGENH FGNPDLQCVS CDCNLDGTER
PSCDPETGEC MCRKGVTGIF CDECAPGHDS EFPACRECHP CHALWAEDVT DVQKASQVLK
KLIPHISDAI QPADNRLLQR VLDLQSKLDS LENLTALAPS AVEEVEELYE AIRNSNDTAH
PNLTLPDLSP LNQQIRKVRQ EAEELLNKTR QKAAEHPCPT LELLDEINKL NNASMLDEER
VRNTNQTLED SMNTRLEAEL NLTACCGQGD LAPLERKVTG LSVVDLNRQI CGGAGLDCSE
CGGARCFLNG RMKCGGPNCD GILPTSQNAS ETARRAANEM LTLPSRLEES KNKLNKAKQE
ALDSKQQAEN MQDRLNATMD SFEMEKTKTK ELIRRAKDFL LDDLVHPDDI EKMARAVLSI
RLPRSPEQIQ SMIEEINNLL SNASRFQDDL KRLEEHTNIT QELLRRAEDV KIRTKSIDVT
EIRRDIYLAE GAQDRANDDL EAASQDTDMT RNRIAESNNN LYHLEAKLMS QRPEDLSRRI
RDVQEKTEQN RRMAADAREA ADAALQNATA VEQEMKNVTR LFEDLKQKNS SQTIQDEAGK
RLKNITDEVE KMKQAIEDKQ RQIQELEDKI LQLIKRKEEK AERVSEMVKE VESLRKEISS
RADAYVICTT
//
