ID H3D9L5_TETNG Unreviewed; 1423 AA.
AC H3D9L5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=DCC netrin 1 receptor {ECO:0000313|Ensembl:ENSTNIP00000017206.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017206.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000256|ARBA:ARBA00009588}.
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DR Ensembl; ENSTNIT00000017422.1; ENSTNIP00000017206.1; ENSTNIG00000014194.1.
DR GeneTree; ENSGT00940000158867; -.
DR HOGENOM; CLU_004256_0_0_1; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05722; IgI_1_Neogenin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR010560; Neogenin_C.
DR PANTHER; PTHR44170:SF8; NETRIN RECEPTOR DCC; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF06583; Neogenin_C; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 20..134
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 138..229
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 237..326
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 331..416
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 430..523
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 529..619
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 624..717
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 724..821
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 836..932
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 938..1035
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1107..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1339..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1423 AA; 154370 MW; B14A6693264095A5 CRC64;
QPSSFGFWRK LPTFCFLLYP KRSDASSSSG IGSFLEFTFT QEPQDTVTVQ GGALQLDCQA
QSDAAVGPPS ITWRKDGVLL STLVDERRRQ LANGSLLVEN VMHSRHHRPD EGEYQCLATL
EGLGSIVSRV ARVSVAGPLK AVTPTKSVSS YLGDTALLEC KVSGEPSPAI RWQKNREDLP
VTSEPDSQLA MLPSGSLQVS RVQPPDSAMY RCLADNPGSS RTGADAELRV LPEPGLPRSL
QFLQRPSRVT ALLGSDVVLE CSASGYPTPS IQWRKGEELI QSWSKKYSLL VGSNLIIRSV
TDDDSGSYSC TAANRNQNIS ATAELSVLVP PQFLNYPSNT YAYESTDVEL ECAVTGNPPP
TVRWMKNGEE VIPSDYFQMV DGSNLQILGL VKSDEGFYQC VAENAAGSSQ AMAQLLLREP
GSPGAALPSA PRDLVPVLVS SRFVRLSWRP PEESGGGVQT YGIYYSQDGV ERERSVNVSE
PESLELMVSN LKPEETYSFR VIAYNDVGPG ESSAPLKITT KPDLQVPSRA ESLRLVALSP
TSVQVSWEPP SHPNGPILGY RLLWTESPSG KEQSVEVNSL TYKMDGLNKF TEYTVRVLAL
NRYGPSPATE AAGVTTHSDV PSAPPQNITL EVVLSRSIKV LWQPPPRSSQ NGVITAYKIK
YRKTGRRGDK EAIEPNNFWY LFTGLEKGSQ YSFQVAAMTA NGTGPFSDWF AAETPENDLD
ESQVPDQPSS LHVRPLPHSI IMSWTPPLSP NILVRGYIIG YGVGSPYAET VRVDSKQRYY
SIENLGGSEP SSHYVISLKA FNNAGEGIPL YESAVTRSLT DKYPTPMPDT SAPMIPPVGV
QAVALSSDSV RVSWADNSMS KNQKTSEVRY YSVKWKTSYS TSGKYKSADT TALSHTVTGL
KPNTMYEFAV MVTKGRKSST WSMTAHATTY EADLSGSAPK DLTVISREGR PRSILISWQP
PMEANGRLTG YILYYTLDKN MPIDDWVMEA ISGDRLTHQV VDLNLDTVYY FRIQAKNAKG
VGPLSEPIHF RTAKVEHPDK MANDQGRGGD PGYWPPDASL IDRSNINESP IGQMRPPHGS
VTPQKNSNLL VIIVVSVGAV TLICTRRSSA QQRKKRASHS TSKRKGSQKD LRPPDLWIHH
EEMEMKNMEK APSVAPSGHD SPIQSCQDLP QVAHSQSESQ IGSKSSHSGG DGDEASSSIS
TLERSLAARR GTRSKMMIPM DTQPSNTPVV SAIPVPALDS SQYSGILPSP SCGFTHNKFS
LRPMPFSTLT VDRGYTPVVS PVPGAPAPVV PAPAEEAQGA GGRSIPTACV RPTHPLRSFT
NPLLPSSMGT IDPKVYTSMM PQSSSGASLP KPQVKTASLG QPGKARSPLL PVSVPTAPDL
TEEAAKAAED SAANVYEQDD LSEQMASLEG LMKQLNAITS SAF
//
