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Database: UniProt
Entry: H3DAJ2_TETNG
LinkDB: H3DAJ2_TETNG
Original site: H3DAJ2_TETNG 
ID   H3DAJ2_TETNG            Unreviewed;       883 AA.
AC   H3DAJ2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 46.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 3 {ECO:0000313|Ensembl:ENSTNIP00000017533};
GN   Name=KCNH3 {ECO:0000313|Ensembl:ENSTNIP00000017533};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017533, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000017533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000017533}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000017533}.
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DR   STRING; 99883.ENSTNIP00000017533; -.
DR   Ensembl; ENSTNIT00000017753; ENSTNIP00000017533; ENSTNIG00000014510.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140833; -.
DR   InParanoid; H3DAJ2; -.
DR   OMA; VIKTNAC; -.
DR   OrthoDB; EOG091G0OXR; -.
DR   TreeFam; TF313130; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    304    332       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    353    379       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    451    475       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       37     85       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       88    142       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      553    670       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   883 AA;  99197 MW;  1FEB1448BACD0607 CRC64;
     GLIAPQNTFL DTIATRFDGT HSNFVLGNAQ VQSLYPIVYC SDGFCELTGF ARGELMQKSC
     MCHFLYGSET SERLTSQMQI ALDERREFKT EIILYKKSEK GSKFWCLLDI VPIKNEKSEV
     VLFLVSHKDI TEIKIMIDEE TGLEIHKISR PPGFNMERRR SRAVLYQLSG HLQKQDKTKS
     KLKINNSVLG ANANPIPEYK VADIQKSCFV LLHYGTFKAG WDWLILLATF YVAITVPYNV
     CFTAVEMRED GGSSARNPPS VSDILVEILF IIDIVLNFRT TYVSTSGQVV YDPRSICIHY
     ATSWLFVDLI AALPFDLLYA FNISVNFGVH LLKTVRLLRL LRLLQKLDRY SQYSAVVLTL
     LMSTFALLAH WMACVWYFIG RSEIESNSST SWDIGWLHEL AKRLGTPYFG SRLSGGPSVR
     SSYVTSLYFA LSSLTSVGFG NVSANTDSEK IFSICTMLIG ALMHAVVFGN VTAIIQRMYS
     RRYLYHTRTK DLKDFIRVHR LPKALEQRMM ECFQTTWSVN NGIDVSELLR DFPDELRADI
     AMHLNKELLE LPLFESASRG CLRSLSLIIK TSFSAPGEFL IRQGDALQAI YFVCSGSMEV
     LKDNTVVAIL GRGDLIGSDF LTQEEVIKTN ACVKALTYCD LQYISLKGLR EVLCLYPDYA
     QKFITEIRHD LTYNLRDSHN TEVQQGIQDK ATVTQADCEI NGSIIQKLPS IKEDEEGSGS
     EGENSPLPRV APLSKVSRGL RSPLRSPLRS PLRSPLRSPL LPPRAIRPAG DHSRPTTLQI
     PVVSFGCLQP DLSPRFVDGI EADNPCGSTQ RFEFSPSGTQ TYMPSPAPVT PAVECYVNSA
     FRLLKTQKMS ALSRQVTAVS QELQEVTRLL RPLFHNASTL LMP
//
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