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Database: UniProt
Entry: H3DAN7_TETNG
LinkDB: H3DAN7_TETNG
Original site: H3DAN7_TETNG 
ID   H3DAN7_TETNG            Unreviewed;      2655 AA.
AC   H3DAN7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   20-DEC-2017, entry version 34.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 1a {ECO:0000313|Ensembl:ENSTNIP00000017579};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017579, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000017579}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000017579}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000017579}.
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DR   Ensembl; ENSTNIT00000017800; ENSTNIP00000017579; ENSTNIG00000014554.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 2.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 4.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2183   2205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2217   2235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2241   2258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2263   2281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2301   2328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2349   2371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2477   2500       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      114    168       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      287    342       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1507   1527       {ECO:0000256|SAM:Coils}.
FT   COILED     2586   2634       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2655 AA;  303592 MW;  FBF6B39670188D9E CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PDAGDLNNPP KKFRVLLFLI
     TPVSLFSSKH QFWHCGSAVA MATSIILFTL LNLVTHAYDP TKPEQEXENK KLLGTVIQYG
     NVIQLLHLKS NKYLTVNKRL PALLEKNAMR VMLDTAGNEG SWFYIQPFYK LRSIGDSVVI
     GDKVVLNPVN AGQPLHASTH QLVDNPGCNE GLSATGLHXP ICGEGKYIFQ IVKSPCDSHY
     FPSNLKKEIY FKSNQQEKNT NTIMNKQLKT CRSLPSVLVR KKCYFKIDCF CRNSYVRLRH
     LCTNTWVHST NQPIDKEEEK PVMLRIGTSA LKEDKDGLLC PVSPAEVRDL DFANDASKVL
     ASIAGKLEKG TITQNERRAV TKLLEDLVFF VVDIPNSGQD VLEIMVNKPN RERQKLMREQ
     NILKQIFKLL QAPFTDSGDG PMLRLEELAD QRHAPFRHIC RLCYRVLRHS QQDYRKNQEY
     IAKQFRFMQK QIGYDVLAED TITALLHNNR KLLEKHITAA EIDTFVSLVR KNREPRFLDY
     LSDLCVSMNK SIPVTQELIC NAVLDPANAD ILIETKLVLS RFEIEGAPLG ENSLESEEDE
     EEVWLFWKDN NNKEIRSKSI RELAQDAKEG QKEDQEVISY YRYQLNLFAR MCLDRQYLAI
     NKISGQLDVD LILRCMSDED LPFDLRASFC RMMLHMHVDR DPQEQVTPVK YARLWSEIPS
     EIAIDDYDND GTSKDEIKER FSQTMEFVEN YLRDVVCQSF PFADKEKNKL TFEVVNLARN
     LIYFGFYNFS DLLRLTKILL AILDCVHIGT AFGFNKLDKD DESKGSNVMR SIHGVGELMS
     QVVLRGGGFL PMTPSISTSR DTVKTQTEPE KQDILVMDTK LKIIEILQFI LNVRLDYRIS
     CLLSIFKREF DESNSQSELP VGGAVEGPNN MPGALDFEHI EEQAEGIFGG SEENTPLDLD
     DHGGRTFLRV LLHLTMHDYP PLVSRALHLL FRHFSQRQEV LQAFKQVQLL VTSQDVENYK
     QIKSDLDQLR SIVEKSELWV YKRQGSEEGM DTGEGLCAEP EHKLVPYFEN SLSNKTKKPE
     STSSYNYRVV KEILLRLSKL CVQEGLSGRK SKKQQQRLLR NMGAHSVVLE LLQIPYEKGE
     DLRMQDIMKL AHQFLQNFCA GNQQNQALLH KHINLFLNPG ILEAITMQHI FMNNFQLCSE
     INERVVQHFV HCIETHGRNV QYLKFLQTIV KAENKFIKKC QDIVMAELVN AGEDVLVFYN
     DRASFQTLVQ MMRSERDRMD ENSPLMYHIH LVELLAVCTE GKNVYTEIKC NSLLPLDDIV
     RVVTHEDCIP EVKIAYINFL NHCYVDTEVE MKEIYTSNHM WKLFENFLVD ICRVCNSTSD
     RKHADTILER YVTETVMSIV TTFFSSPFSD QSTSLQTRQP VFVQLLQAVF RVYHCNWLIP
     VQKGSVENCI KVLSDVAKGR AIAIPVDLDN QVHNLFVKSN NIVQKTAMSW RLSARNAARR
     DSVVTASRDY RNIIERLQDI VSALEDRLRP LVQAELSVLV DVLHRPELLF PENTDSRKKC
     ESGGFICKLI KHTKQLLEEN EERLCIKVLQ TLREMMTKDR GYGEKHLILS DLLSAVFGFP
     PHRHIRCVQQ LGHNQPEKLL EDQKRGEALR QILVNRYYGN FHRSGGRRDS LTFANSPLSP
     IGPGRNQSGL GVPGGLSRGE MSLAEVQCHL DKEGASDLVI DLIMNTTSDR VFQESILLAI
     ALLEGGNTTI QRSFFCRLTE DKKSEKFFRV FYDRMKLAQL EIKATVTVNT SDLGNRKRVD
     DSQDKDGPVR KKVRESSVVM TEDVREQLLE ASSATKKAFN SYRREADPED HFNVADGQSN
     TGDKNQDDGE MSFVIVIMQP ILRFLQLLCE NHNRDLQNFL RCQNNKNNYN LVCETLQFLD
     CICGSTTGGL GLLGLYINEK NVALINQTLE SLTEYCQGPC HENQNCIATH ESNGIDIIIA
     LILNDINPLG KKRMDLVLEL KNNASKLLLA IMESRHDSEN AERILYNMRP KELVEVIKKA
     YLLGEVEIQD TKEEDKFRGE PRNLYTEHNH YVETHRICMT FFSFEKKKKI GGVVAVKFCR
     TLTEFISFYA SLKIQRRATL GTPTQCMFVP LHLSLPHHSS SNKKVAKLSS FLLRFRSLFL
     SQNVTKQIRA QPVLYWCSRN MSVWSNICFN LALLMNLLVC LFYPLEGVQG VMLDPHLSAM
     LWMGVFAALV IVLVMPQQLS VRALVIITIL RLIFSVGLEP TLFLLGAFNV CNKIIFLISF
     VGNRGTFTRG YKAMVLDFEF LYHLIYLIIC CLGVFVHVFF YSLLLFDLVY REETLLNVIK
     SVTRNGRSIV LTAVLALILV YLFSIVGYIF FKDDFILEVD RVPNATIKGG GSLASVFVPT
     GMCQGGIDQN CTAKAQLEDM MDNKDKDDDV ERTCDSLLMC IVTVLSHGLR SGGGVGDVLR
     KPSKEEPLFA ARVIYDLLFF FMVIIIVLNL IFGVIIDTFA DLRSEKQKEE ILKTTCFICG
     LERDKFDNKT VTFEEHIKEE HNMWHYLFFI VLVKVKDSTE YTGPESYVAE MIKEHNLDWF
     PRMRAMSLVS SDAEGEQNEI RNLQEKLEST MRLVANLSGQ LSELKEQMTE QRKQKQRIGL
     LGHPPHMNIN PQQPA
//
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