ID H3DB42_TETNG Unreviewed; 1940 AA.
AC H3DB42;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Myosin, heavy chain b {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017734.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017734.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSTNIT00000017957.1; ENSTNIP00000017734.1; ENSTNIG00000014702.1.
DR GeneTree; ENSGT00940000162888; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..783
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 660..682
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1886..1940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 848..1162
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1940 AA; 222645 MW; 9A6E29AC712850C0 CRC64;
MSGDADMECF GPAAIYLRKP ERERIEAQNT PFDAKTAYFV TEPKEMYLKG KLIKKEGGKA
TVETLCHKTL TVKEDEIFPM NPPKFDKMED MAMMTHLSEP SVLYNLKERY AAWMIYTYSG
LFCVTVNPYK WLPVYDSVVV TGYRGKKRIE APPHIFSISD NAYQFMLQDR ENQSILITGE
SGAGKTVNTK RVIQYFATIA VAGAKKDQQP ASKMQGSLED QIIAANPLLE AYGNAKTVRN
DNSSRFGKFI RIHFGTTGKL ASADIETYLL EKSRVTFQLS AERSYHIFYQ LMTGHKPELI
EALLITTNPY DYPMISQGEI TVKSINDIEE FIATDTAIDI LGFTAEEKIS MYKLTGAVMQ
HGNMKFKQKQ REEQAEPDGT EVADKIAYLM GLNSADLLKA LCYPRVKVGN EFVTKGQTVP
QVNNAVMALC KSVYEKMFLW MVVRINEMLD TKQARQYFIG VLDIAGFEIF DFNSLEQLCI
NFTNEKLQQF FNHHMFVLEQ EEYKKEGIEW EFIDFGMDLA ACIELIEKPM GIFSILEEEC
MFPKATDMTF KNKLYDQHLG KTKCFEKPKP AKGKAEGHFS LVHYAGTVDY NITGWLDKNK
DPLNDSVVQL LYQKSSVKLL AFLYASHSGT EAETGGGGKK GGKKKGGSFQ TVSALFRENL
GKLMTNLRST HPHFVRCLIP NESKTPGLME NFLVIHQLRC NGVLEGIRIC RKGFPSRILY
GDFKQRYKVL NASVIPEGQF IDNKKASEKL LGSIDVDHTQ YKFGHTKVFF KAGLLGVLEE
MRDEKLAELV TMTQALCRGF LMRCEFVKMM ERSRDAIFTI QYNIRAFMNV KTWPWMKLYF
KIKPLLKSAE TEKEMAQMKE DFEKTKEDLS KALSKKKELE EKMVSLLQEK NDLLLQVQTE
SENLSDAEER CEGLIKAKIQ LEAKLKETTE RLEDEEEINA ELTAKKRKLE DECSELKKDI
DDLELTLAKV EKEKHATENK VKNLTEEMAS QDEAIAKLTK EKKALQEAHQ QTLDDLQAEE
DKVNSLTKAK TKLEQQVDDL EGSLEQEKKL RMDLERAKRK LEGDLKLAQE SIMDLENDKQ
QSEEKIKKKD FEISQLLNRI EDEQTLGIQL QKKIKELQAR IEELEEEIEA ERAARAKVEK
QRSDLSRELE EISERLEEAG GATAAQIEMN KKREAMFQKL RRDLEESTLQ HEATAAALRK
KQADSVAELG EQIDNLQRVK QKLEKEKSEY KMEIDDLASN MEAIAKSKSN LEKLCRTLED
QLSELKTKND ENVRQLNDVS AQKARLQTEN GEYVRQLEEK EALVSQLTRG KQAYTQQIDE
LKRHIEEEVK AKNALAHAVQ SSRHDCDLLR EQYEEEQEAK AELQRSMSKA NSEVAQWRTK
YETDAIQRTE ELEEAKKKLA QRLQDAEESI EAANSKCASL EKTKQRLQGE VEDLMIDVER
ANAVAANLDK KQRNFDKVLA EWKQKYEESQ AELEGAQKEA RSLSTELFKM KNSYEEALDQ
LETLKRENKN LQQEISDLSE QLGETGKTIH ELEKGKKTVE GEKAEIQTAL EEAEATLEHE
ESKILRVQLE LTQVKSEIDR KLSEKDEEME QIKRNSQRVI ESMQSSLDAE VRSRNDALRI
KKKMEGDLNE MEIQLSHANR QAAEAQKQLR NVQGQLKDAQ LHLDEAIRGQ EDMKEQAAMV
ERRNNLMLAE IEELRAALEQ TERSRKVAEQ ELVDASERVG LLHSQNTSLI NTKKKLESDL
IQIQGEVEEA VQEARNAEEK AKKAITDAAM MAEELKKEQD TSAHLERMKK NLEVTVKDLQ
HRLDEAENLA MKGGKKQLQK LESRVRELEG EVEAEQRRGV DAVKGVRKYE RRVKELTYQT
EEDKKNVARL QDLVDKLQLK VKAYKRQAEE AEEQANTHLS KYRKVQHELE EAQERADIAE
SQVNKLRAKS REIGKSKESE
//
