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Database: UniProt
Entry: H3DC93_TETNG
LinkDB: H3DC93_TETNG
Original site: H3DC93_TETNG 
ID   H3DC93_TETNG            Unreviewed;      1620 AA.
AC   H3DC93;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000018136, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000018136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000018136}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000018136}.
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DR   STRING; 99883.ENSTNIP00000018136; -.
DR   Ensembl; ENSTNIT00000018360; ENSTNIP00000018136; ENSTNIG00000015082.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H3DC93; -.
DR   OMA; FVIVFMG; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005450; VDCC_L_a1ssu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF190; PTHR10037:SF190; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01634; LVDCCALPHA1S.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     61     80       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    100    121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    224       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    317    339       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    417    436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    456    476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    523    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    584    604       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    657    683       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    814    836       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    856    877       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    935    964       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1107   1126       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1141   1160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1172   1190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1235   1257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1325   1349       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1365   1400       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1620 AA;  184696 MW;  99FF53431EF4DDCC CRC64;
     TNADAAKPVI MNEEELKRKQ REKLKKLQAT GGNPRPARSL FFFTLKNPFR KACINIVEWK
     AFEIIILLTI FANCVALAVF LPMPEEDSNN TNASLESLEY IFLVIFTLEC FLKIVAYGFV
     FHEGAYLRNC WNILDFVIVF MGLFTFALDT INKIAGVPLE KGGGFDMKAL RAFRVLRPLR
     LVSGVPSLQV VMNSILKAML PLLHIALLVF LLVTIYAIMG LELFKCKMHK TCYYTGTNIY
     STAEGELPAP CAQAGNGRRC TINSSECRPG WEGPNNGITH FDNIGFAMLT VYQCITMEGW
     TKVLYWVNDA IGNEWPWLYF VPLILLGSFF VLNLVLGVLS GEFTKEREKA RSRGEFQKLR
     ERQQLDEDLH GYMEWITHAE VLDADREGKG QGQEPRLLPL TGGDSETDSL YGLEGKICGG
     AGLLRWFLFL FFSRLARRWN RFFRMKCLVY VKTKSFYWLV MFLVFLNTLT IATEYHHQPQ
     WLTSLQDMAS RVLLVLFIVE MFIKMYALGL RAYFMSLFNR FDFFVVLCGI LEMILFSAGA
     VTPLGFSVLR CIRLLRILKV TKYWTSLSNL VASLLNSVRS IASLLLLLFL FIVIFSLLGM
     QVFGGKFNFS DHRPRRSNFD NFPQALISVF QILTGEEWTN IMYNGIMAYG GPVFPGILVA
     IYFIVLFVCG NYILLNVFLA IAVDNLAEAE SLTSAQKEKA EEKLRRKLLR RPGSNSPLLH
     PSNSPSRSKM PEKTDELKID EFESNVNEVK DPFPPNDFPV VGDDEEVEPE IPISPRPRPM
     ADLQLKEEAV PLPEASSFFI FGPQNKFRKL CYKIINASSF TNLILLFILL SSISLAAEDP
     IDPKSYRNQI LSYADIVFTT VFTIEIVLKM TVYGAFMHKG SFCRNSFNIL DLIVVGVSLL
     SMGMESSAIS VVKILRVLRV LRPLRAINRA KGLKHVVQCV FVAIKTIGNI VLVTMLLNFM
     FACIGVQLFK GKFYSCTDSS KLTEEECQGF FLKHMENSLQ DTVLAKREWL NSDFNFDNVL
     YGMLALFTVS TIEGWPELLY RAIDSDKEDM GPVFNNRVDV TFQEQGEQEY KDCELDKNQR
     QCVQYALKAR PLRCYIPKNP YQYRVCYFEY LMFFLIMLNT LCLGMQHCNQ SDHVTKLSDT
     LNLIFTVLFT VEMILKLMAF KIKGYFGDPW NVFDFIIVIG SVVDVILSEV DDSENASVSI
     TFFRLFRVMR LVKLLNRSEG IRNLLWTFIK SFQALPHVAL LIVMLFFIYA VIGMQIFGKV
     ALVDGTQIHR NNNFQTFPQA VLMLFRCATG EDWQEVMMAS MYGKKCDPKS EVLPGEEYTC
     GSNFAVIYFL SFYCLCAFLI LNLFVAVIMD NFDYLTRDWS LLGPHHLDEF KKIWAEYDPE
     ATGRIKHLDV VTLLRRIQPP LGFGKFCPHR AACKRLVGMN MPLNSDGTVT FNATLFALVR
     TALKIKTEGN FEKANEELRA IIKQIWKRTS MKLLDQVIPP LGDDEVTVGK FYATFLLQDH
     FRKFLKCQEE YYGYRPTKKS ASGPEIQAGL RAIDEELAPE MHRTISGDLQ NEEEMDGAME
     AGEEGIYHRS HSLFGNRGDA FPSDPANEQP QHVTNQRPLR FSDSQPEAPP SSDFITPTAP
//
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