ID H3DF28_TETNG Unreviewed; 984 AA.
AC H3DF28;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Pleckstrin homology domain containing A5 {ECO:0000313|Ensembl:ENSTNIP00000019122.1};
GN Name=PLEKHA5 {ECO:0000313|Ensembl:ENSTNIP00000019122.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019122.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019122.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3DF28; -.
DR STRING; 99883.ENSTNIP00000019122; -.
DR Ensembl; ENSTNIT00000019350.1; ENSTNIP00000019122.1; ENSTNIG00000016033.1.
DR GeneTree; ENSGT00940000155728; -.
DR HOGENOM; CLU_008216_1_0_1; -.
DR InParanoid; H3DF28; -.
DR OMA; AXTESAG; -.
DR TreeFam; TF329090; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR12752:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 106..205
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 61..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 710..737
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 61..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..879
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 112358 MW; E59633819413181C CRC64;
EPWSFIALKT FMCHNERKVT CKHPISSLPS QDNCIFVINE QSASKAPANE KMERPLSTMS
EASNYTGASD NTTNAESPAG RPSRSSKKIH NFGKRSNSIR RNPSAPVIKR NWLYKQDSTG
MKLWKKRWFV LSDLCLFYYR DEKEEGILGS ILLPSFHISM LSVDDHINRK YAFKAAHPNM
RTYYFCTDTA KEMESWMKVM TDAALVQAEP IKSLTPVLIR LDKLKVEDCG PQESNHVENH
RPQLTEPEIQ NNERNREVAR DPAAAVSPTT TEEERKQRDA ERYGFQKDGG ERERPLTKIN
SVKLQPAQAA AVKNSIASAQ VSTETDSRRS PQVNGSGEQS PANGMGAPPQ KTPTPEADRS
LSRTSSMQQL EQWVRTQRGR GQEDDNRSVA SYQTLPRNMP SHRVPYMPQY GETYCSIPRN
SIAQRDSICS ISPSLYDQAL GPSPADKRRS MRDDTMWHLF EWQQRQAYAR QPGLYNNMSS
PKTMMNLSEH AVPMHSIPPS PSHGSLSMYG GYSPMRSYSM LGARSEVSSP IYRRDLNFER
RQRPQYNKYA YTPDRRSMPV GIPVQTITAQ SLQSKTPEEL TLLLIKLRRQ QAELSSIREH
TVAQLMQLNM DGDHPKNDIL SHHLQRNLMY LDNQDKMKEN DPLIIMTHTM IENSAPRPQL
YQQVSIRNVT VLLFFCLGPD DYRDYVYTCL PEEMDVDTKL SRMCELDKIL RTQEEKIQQL
YREKHTLETA LLSASQEIEM GSDNPAAMQS VIQQRDLLES GLLSTCREIS RVTAELERLW
REYDKIEGEV TVTKNILLEQ LEALGSPQME PPSQQHIFFQ KELWKIQDVL EALSQHKAQR
HSGVNPYKHR SEEEDSAPPR PPLPQSYEPI PPTVPPLPSR ASIRPSSLYR PEDRKVNSRN
GTQSGPDYRL YKSEPELTTV TEVDEIMEKT EANTHPKLLE TKAPFYFCMS GTSYPVGIVP
PRTKSPVPES SSIASYVTLR KNKK
//
