ID H3DGN7_TETNG Unreviewed; 540 AA.
AC H3DGN7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Lysosomal cobalamin transport escort protein LMBD1 {ECO:0000256|ARBA:ARBA00039618};
DE AltName: Full=LMBR1 domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042599};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000019681.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000019681.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
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DR AlphaFoldDB; H3DGN7; -.
DR STRING; 99883.ENSTNIP00000019681; -.
DR Ensembl; ENSTNIT00000019911.1; ENSTNIP00000019681.1; ENSTNIG00000016581.1.
DR GeneTree; ENSGT00390000002581; -.
DR HOGENOM; CLU_028341_1_0_1; -.
DR InParanoid; H3DGN7; -.
DR OMA; FWAQFVF; -.
DR TreeFam; TF329170; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 14..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 540 AA; 61708 MW; C52C02E997DD4E5C CRC64;
EVKMAEQWLL TESVVGWSIF TFILLAILAF CWFYIRKYQS RQESEVVSTI TAICALAIAL
ITSALLPVDI FLVSFMKYPN GTYKEWAANN VTREQIENSV LYGYYTLYSI ILFCVFLWIP
FVYFYYEEKD DDNMNKCLQV KNALKYTIGF VFVCVALLLI GAFVPLEPAP GHNSTQWQKV
QYLFEELGSS HGLYALSFSI SSLTLIGMLA VITYTAYGMS VLPLNLIKGT RSVAYERLEN
TEDTEDVEHQ IEKLKSKCSD GRPLSSRDRN NLRELESRLL VLRRRGRHLE IAEKNCCTKV
GRALRPVKIL LGIFFILVAL LFIIALFISN LDKALHSAGI SSGFIIFGTN LTNPLNELLL
VLQPVFPLDY ILITVITVYF VITSMAGIRN MGIWFFWIRL YKIRPKRTRP QALLFLCMIL
LLIILHTSYM IYSLAPQYVM YGSQKYLVQS PARFTPGNAT SDTTRICDAN APEDQCTVTR
TYLFLHKFWF FSTIYYFGNW AFVAAFLIGL AVSCCRGKKS VIEGEVEADD SDISDDEYLH
//
