ID H3DHP4_TETNG Unreviewed; 1132 AA.
AC H3DHP4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Collagen, type XXVIII, alpha 2a {ECO:0000313|Ensembl:ENSTNIP00000020038.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000020038.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000020038.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H3DHP4; -.
DR Ensembl; ENSTNIT00000020269.1; ENSTNIP00000020038.1; ENSTNIG00000016919.1.
DR GeneTree; ENSGT00940000163195; -.
DR HOGENOM; CLU_009158_0_0_1; -.
DR InParanoid; H3DHP4; -.
DR OMA; YSIHWYY; -.
DR TreeFam; TF331207; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF18; COLLAGEN ALPHA-1(VI) CHAIN; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00131; KU; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1132
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003581989"
FT DOMAIN 50..232
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 805..985
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1079..1129
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 251..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..394
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..666
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..711
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1132 AA; 116833 MW; C184753B512ED0C1 CRC64;
VWMRMFSSTL VLLLSALTSV WTQTPLEEKN PVTTVLTTGT HGKQEECGLE LSFLLDSSES
AKDNHEQEKE FAMKVVDRLE GTRLRSGRSL SLRVALLQYS SHVITEQTFK DWRGTENFKA
RITPIVYIGH GTYTTYAITN MTKIYLEESS PGSIRVAVLL TDGVSHPRNP DISSAVADAN
NQGIRFFTLG ITRAAKEPTN IAQLRLIASS PASRFLHNLQ DEDIVEKIVT EITTLANQGC
PLAQKCACEK GERGLSGPAG KRGRPGEDGA PGVKGEKGEH GPGGLPGQEG PEGKPGYKGE
KGGRGECGTP GTKGDMGPVG LVGTRGPRGL QGVPGPPGDI GPEGIQGKQG ERGPTGPPGI
QGETGKGLPG PKGDIGFQGQ PGPPGPPGIG EQGPPGPQGP QGVQGSKGPP GEGLPGLKGD
QGLPGPRGPR GQQGVGIKGE KGDLGPPGFP GPTGPIGVGL QGEKGVEGPR GPPGVRGIPG
EGLPGPKGDQ GLPGEQGVPG DRGVGEAGPK GEPGAAGIGG LPGLPGEDGA PGQKGEPGLP
GLRGLEGAQG IGTQGEKGDQ GQRGIRGLHG PPGIPGPSGP KGERGLPGQQ GVPGQPGRSV
PGPKGDVGSL GPPGPIGETG HGLPGPKGDR GHPGLPGPYG PKGEGLPGPM GPTGLPGLPG
EPGPEGLGIP GPKGDIGFRG LPGLPGPPGA GIQGPPGNIG RPGPPGPRGP QGDGIQGPKG
EPGSQGMTGP RGPAGDGFPG AKGDRGFTGE KGVKGSKGDL GDSGLPGEAG TPGAKGEAGL
TREDIIKLIK EICGCGIKCK ERPMELVFVI DSSESVGPEN FEIIKDFVIR LVDRTTVGRN
ATRIGLVLYS LEVRLEFNLA RYVTKQDIRQ AIRKIPYMGE GTYTGTAIRK ATQEAFLNAR
RGVSKVAIVI TDGQTDKREP VKLDLAVREA HAANIEMYAL GIVNASDPTQ AEFLQELNLI
ASDPDSEHMY LIDDFNTLTA LESKLVSQFC EDENGALIYN HVTNGHRSIN NGHGVLINKT
SVEPVRESSM ANDVVSNVSS SSTATLSSDS SESKQLHSTT LPGKWRFSSP EETPIDPRCT
LSLDQGSCRN YSIHWYYDQQ ANSCAQFWYG GCGGNENRYG TEDECRRTCV VR
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