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Database: UniProt
Entry: H3DI06_TETNG
LinkDB: H3DI06_TETNG
Original site: H3DI06_TETNG 
ID   H3DI06_TETNG            Unreviewed;      4931 AA.
AC   H3DI06;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   20-DEC-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSTNIP00000020150};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000020150, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000020150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000020150}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000020150}.
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DR   Ensembl; ENSTNIT00000020381; ENSTNIP00000020150; ENSTNIG00000017023.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 6.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4259   4282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4469   4490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4537   4556       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4683   4708       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4731   4753       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4774   4792       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4812   4835       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    219       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      227    282       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      288    343       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      353    410       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      607    811       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1028   1225       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1350   1555       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4022   4057       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3330   3350       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4931 AA;  553451 MW;  3D0C3EAA409EF884 CRC64;
     MSDFGEGDEE FQFLRTGDEV VLQSIFTLRG EHVKICLAAE GFGTRLCRLE PIFNCKNVPP
     DVSVCGFVLA HCLSVRALQE MLTHTEHLAA EILHLQLAAG GGHRTLLYGQ AVLFLHSYSS
     MYLSCLSSSQ SATDKLAFDV GLQEDKEGET CWWIVHPSSR QRSEGEKVRV GDDLILVSMS
     SERYLHLSVG SGSDSSSSLS DSLSVSASFQ PTLWSVAPIY SGGGVAQGYL KGGDTFRLHH
     SHSDACLTIA SADQGEEPQK VMHYESGAVS SHARSLWRLE ILHVVWSGSH TCWGQPFRLC
     HMTTGRYMGL TEERGLHLVE RDKADVRMSS FCFRSSKEKL DPGTRTNADG MGSPEIKYGD
     SVCYVQHVDS GLWLTYRPVD AKSSRLRSTQ RKAILHSEGH MDDGLRLSRC QREESHTARL
     IRSASFLFTN FIRKQDSCSQ HGNQVSVCSP GEMMKRSLQD LISYFYPTPE TVEHEAKCHN
     MVVLKNRQNM FQEEGVIDLV LVCIDHLHQH IGTSQCAEAA QEDSEEEWES CLDGFYKLLA
     ALLRGNRANC ARFSASIDWL ISKLDWLEAA TGVLEVLQCV LLESPEALNV VKENHIHSVI
     SFLDKHGLNH KVLEVLCALC VCHGVAVRYN QNLICDKLLP ERDLLLQTRL VNRVTSMRPN
     IFLAFSEDSA QHRRWYYEVV VDHLDSFLTS EPTHLRVGWA CTEGYRPRLS GGEGWGGNGV
     GDDLCSYGFD GLHLWAGGVG RSVSSPFSHS LKDGDVVSCC LDLSAPCISF RVNGLPVQGM
     LENFVAEGLL YPVVSFSAGV RIRFLFGGQH GEFRYLPPPG FTACSDALLP KVKLKVEPCQ
     KYILNREEGK HDLIGPWIPT APVVFIPAPV DISKVSLPPQ LEDIQEKLAE NIHELWAMDK
     IDLGWTYGPV RDEAKKNDPS LAEFSKLSEH ERNQNLHVAQ DTLRTLLAFG FCIGFNEGHS
     NDRVRNKRLA AKYEQPGGYR PAPVDLSQVL LSSEHQEVVN LLAENDHNVW ARERIAQGWT
     YGTQQDVKAK RSPYLVPYSF LDEKTRRLSR DSVREVVGTL LAFGYSLDPH SLKQATLANQ
     CLFSAEKCRV FRPDKSHAVS RGKWYFEFEA VTAGKMRVGW ARPSCSPSRE LGSDDRAFVF
     DGFEAQWYHQ GAEPLGRSWQ RGDVVGCLVD MDESTMMITL NGELLFDARG SELAAKDFDI
     SDGLLPVASL GVNQVGRLNL GRCAASLQYF TVCGQQEGYQ PFAVNMARDP ALWISWQQPQ
     FSSIRPDDHI QVGVTRASGS VGSLSSLRVS QRLFAHYNGS SQISFFRLSM HIECASVLIS
     PAGGVLPVAS SSLSPGRREQ EEVDPDFEVL RKSALTFAGS RDELNHKDHN QEKTTRMKHR
     FLLKRNKPGL VSSNSSARLL EDVVFDKENC DHLIQSSRYY YSARVLPGQE PFNVWVGWVT
     SNFHSHDATF DPDGVHTVTV TLGDDSGKVQ ESIKRRVCYM VCAGEATGLA QSRRSSGLEI
     GCLIDTATGL LTFTSNGVEM STFFQVEACT KLFPAVFVRP TTTCMFQFEF GCIKNAMPLS
     AGLLRSQRCN VTPHCPPRIQ VQQLKPGSWT RLPSQAVKVV VDQPDAYGGW TIQCSEALQV
     MNLQIPDENR CVDILELSEL DDLLTFHLHT LRLYCSLCSL GNTRVSHAIC SYLDTSQFLH
     AIQNPHLPGL LRSVFYQLLI QVHLSSHTTA CLMMNHEYII PMAAKAGDTT LYPSSFTGHN
     GGNGITNSSH CTSLKPQMHF SSPSFVSNYA LEGNYTAERN HGDSPEFPLD LLKNLTIQML
     TEAVTALCQE VRDPVGGTIE LLLVPLIKLA YSLLVMGVLE DEDLGKVLRL LDSEVSFTNS
     QSSMDEEKED EKDDEKEHSL HHHQKDSHPK IGLLQIKLPE AVKLELCHLL SYLCDCQMRQ
     RVEAVAAFSD TFVCQLQENQ RFRYNEVMQA LNMSAALTAR KTKEFRSPPR EQINMLLSFR
     DDEVSCPCPV QIQELLHNFH HLFKTHCGIE SESDGEDEEA AESVRTQILS QVAKVIGIKK
     KPLEVDASKP VASTLETLKH LVSKTLVHWS QEKMQDPELV RAVFSLLHCQ YQGLGGQMAG
     PLSRTYTISH TSVDDTMALL SSLSQIRSLL CVRMGKEEEK LMIRKLGDII NNKVFYQHPD
     LMRTLGMHET VMEVMVNVLG EGESKEIAFP KMVASCCRFL CYFCRISQHN QGALFDHLSY
     LLENASVGLA SPSMRGATPL DVAAASVMDN NELALALTES NLQKVIHYLA SCGLKSCPML
     VAKGYPDIGW NPVEGERYLD FLRFAVFCNG ESVEENAYMV LRLLIRRPEC FGPALQGDGG
     NGLLAAVREA IRISDDPSMD GPSGPHQSTR SMFIPVYQDN DDDLIHMGHA MVTFYSALID
     LLGRCAPEMH LIEGGKGEAL RVRAILRSLV PVHDLEGVIS SSFCLPSVTK DGGVVEPDLS
     AVFCPDHKAA MVLFLDRVYG IQNQSFFLHL IEVGFLPDLQ AAVSLDTVDL ASTDMALALN
     RYLCASVLPL LSKCSALFCD LEDHVLLVDS LIQAIYSLSH ALSLTKAQRD TIEDCLLALC
     SKLQPSLMQP LLRRLVFDVP HLPEHNKLAL KLLTSHYEQR WKYYSMVGEP GDHSLASEEE
     LHLSRKLFWS VFKDLNKKPY EPQLFRLCVQ CLAAVAKALP PDHTDAGCTS AMEGKASADE
     QFDPQPIDTS NVSVPERLEF IVNKYAEHTH EKWSLDKFAN GWVHGEQLCE SSKVHPLLKP
     YRTLAEKEKE AYRCAIKETI KTMLAFGWSI ERTKEADAHS VHTCARRVSQ SGQQSFEGTS
     TFSPKPTDVS TITLSWDQCA MAEQLAENYH STWAKRKKLE LQGRGGGGHS MVVPYDALTA
     REKTKFRERA QDVLKFLHLN GYTVWRDRRT VEMDFPAVAN CFGSTLLMQF LSHTENTQEH
     MLEMEVMQAR GQTSKGERTQ LRQPVQVFHK VILPLLEEYV RTHCLYFLSS MSLSGKRGHA
     SNKEKEMIAS LFCKLAALIR HRMSLFGNEA SAVSNCLCTL AQALDARTLM NSASESVRSS
     LDSFFESSAA DLEMTVENLC VSVARLSQSR SQHARGVARV LSYTSVVLLP TLTSLFQHLG
     LQNYGGDLLV GTIQVSCYKI LNSLYSLGTT SSIYMEGQRP AAGACLAALA ATFPVCFLEP
     DLNQNNPYSI YNTASALEKE ELGLPDHAGD MCPLLPSLEQ ALGDVKQLAA AGAGARQSQY
     IHVTEVVLPM LCSYMSLWWS WGPEGQPNSP LCTTVTPQHA SDLLGHVLRI IHNHVGTSQA
     DWMKRMAVHC LSITCHAHPE LLKTHFLPLM EKLKKRAEGV LLEEERMKAD AGDSSEAELE
     IQQKFMVLVA DLYAFYPLLI PFVDSNRARW LKESTPEAEQ LFIMVAEVFT FWAKSHNFKW
     EEQNYVVQNE INSLLFLVKS NKLSKFFNFQ LNHEKRKVKK KGDRYSTHTS LVVASLKRLL
     PVGLRNCLLS DRSLITLAKN GFTQKDTEDE IRQHIFSAFT LLQTQDHSFL NDEVNDAERG
     GQRGKTADVQ KAVDRVLNMG RVLCYLDQVE HPQRNRKTAR HKILSKQRKR AVVACLRMAP
     LYNLPRHRAV NLFLQGYNKT WISTEDHSFE EKLVEDLALS AKVSGGVAEN DTVDGIKAID
     PLLQLITLFS QTALMESSKL ENGRLYQSYA AIMAKSCQRD DDGDGKEQEL ESFEEKELEK
     QKLLFRQARL HRRGASEMVL QIISASRGLM GSVIAPTLKL GIALLSGGNA AVQQKMLVYL
     RERRDVGFFQ SMAGLMLSCS VLDLSAFERQ NKAEGLGMAM DESSADKVMP DKDVTCDLFR
     FLQLLCEGHN SEFQNYLRTQ AGNNTTVNIV ISTVDYLLRL QESVSDFFWY YSGKAAIDVH
     GQHNFSKAIE VSKQVFNTLT EYIQGPCAGN QESLAHSRLW DAVIGFLHVF AHMQMKLPQD
     SRQIDLLKEL LDLQKDMVVF LLSMLEGNIV NGTIGKQMVD MLVESSGNVQ MILRFFDMFL
     KLKDFTSSDA FQAYDPDFKG CVSRKDFQKA MEGCKRFSQA ETHFLMSCMG PDDREKVDYE
     AFVDGFHEPA QDIGFSIAVL LTNLSEHMPN DSRLRTFLEV AESVLTYFQP FLGRIEILGS
     GKRIERVYFG ISASSRTQWE KPQVKESKRQ FVFDVVNESG DKEKMEMFVN FCEDTIFEMQ
     LAAQLSGSGV EERHVEASPE EKGDTNGLDN KGIGVMCQWL VLTSVLSVKA LMKMSVKDVL
     VSAVVFLKFV LMAQFRCVLI VVRSIWYVLH RAFLSGELIE GAKRARISEM LGGILEPTLD
     EVMGGPRGTR LRKGSSSLTL QKELSGSRLA QTMASTRDMH VLSDIFGLTV KKEGSGYRLI
     SKDLTDSLTD LFTPEPQTHI HQEEKTEEKG ADGKQNKSDQ NSEAILKDPK WRAQRLNPKS
     KEAENQPSAL WEMVSTHNKS MLNYFARNFY NLRVLALFVA FAINFILLFY KVASSPAAQV
     EEKEMPSAYS AGDDAEEGTV CFVLEERSGY MEPSLRFLAV AHTIISFFCI FGYYCLKVPL
     VIFKREKEVA RKLEFDGLYV TKQPPEEDIK GQWDRLVVNT PSFPSNYWDK FVKRKVMDKY
     GEFYGCEKIS DLLGLDQAAL DCSSERKGRK RLRRSTVWSH LFSSIDVKYQ VWKTGVVFTD
     NSFLYLAWYM AMSVLGHYNN FFFAAHLLDV AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV
     VVYLYTVLAF NFFRKFYNKS EDKDARDMKC NDMLTCYMFH MYVGVRAGGG IGDEIEDPAG
     DEFEVERIVF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMET KCFICGIGSE
     YFDKVPHGFE THTLQEHNLA NYLFFLMYLI NKDETEYTGQ ESYVWKMYQE RSWEFFPVGD
     CFRKQYEGQL G
//
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