ID H3DK01_TETNG Unreviewed; 1626 AA.
AC H3DK01;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=Intersectin 2b {ECO:0000313|Ensembl:ENSTNIP00000020847.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000020847.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000020847.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 99883.ENSTNIP00000020847; -.
DR Ensembl; ENSTNIT00000021080.1; ENSTNIP00000020847.1; ENSTNIG00000017697.1.
DR GeneTree; ENSGT00940000155936; -.
DR HOGENOM; CLU_002819_2_0_1; -.
DR InParanoid; H3DK01; -.
DR OMA; CIAINEK; -.
DR TreeFam; TF324293; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08375; C2_Intersectin; 1.
DR CDD; cd00052; EH; 2.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11990; SH3_Intersectin2_2; 1.
DR CDD; cd11994; SH3_Intersectin2_4; 1.
DR CDD; cd11838; SH3_Intersectin_3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR035738; Intersectin-2_SH3_2.
DR InterPro; IPR035740; Intersectin-2_SH3_4.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF6; GUANINE NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 3.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..1626
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013084872"
FT DOMAIN 20..108
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 52..87
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 246..335
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 279..314
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 720..781
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 836..894
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 918..976
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 986..1050
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1060..1119
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1143..1329
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1368..1476
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1484..1600
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 966..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 367..395
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 431..522
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 557..591
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 619..714
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1626 AA; 182751 MW; 0226A39525828DDD CRC64;
ILFVSFLLGG SSIWAISPEE RNKHDQKFDT LSPLMGYVSG EQAKKFFLQS GLPASVLAEI
WALADMNKDG KMDRLEFSIA MKLIKLKLQG TSLPSALPII MKQPPVPAPS LNKPISSMTN
PAYAPGLATL TPMPGLSPLV TTATGLSPLI TPTPTHPLMP TVGNTTLPNG SMGILQPFPA
GTLATGLPLG VSPTPSLLDL GSASYLKFHA ASLCRLCSSV SSASSSPAAV SPITAGPSDW
AVPHASRLKY RQQFNGLDKL MTGYLTGQQV RAAMATTMLS QTQLASIWNL ADVDKDGKLK
AEEFILAMHL VDLAKSGHAL PLTLPTELVP PSQRTAVNGS VSSLMDDLDI EPPQKAKANY
TFEDKFKANL ERGNAELEKR RLALQEAERR EQERRAGKDF SRCLAGSRPH LLCPPWVRFQ
AAQRELERQK KEEWERQRRG ELQKKKQQEQ EDIVRLRAKK KSLELELEAV GNKHRQISDR
LRDFQNKSKF QRTELDLTNQ RMETRQRDIT SLQKELEDFQ RKLSQLTPEQ KRLTQKLKNM
ALNNKSVPAV SALKVGVVEK KGTCLKLRQQ LESLEKETAA KLAEMDQYKK DAQCVVAEDS
MLQAAFCLLS CLRNLFYLLK DLKEREQKQQ AALDKLRGVK EEKRRELMRR KELEAQRTRL
IKLEKERQWQ EKLRRDEEER QKRIQEEREA KKREEEEKER QALIQAAKEE AERQLRAKSA
ALTPFKALYP FTARNSEELS FEADDILEVD ETTEREEGWL YGSKQGKMGW FPESYVERVA
PSDLASSPPA PAPKPSIQSQ LVSALVAAKA VGTKSAFTPT HSTNAAPPDT HGQKVVGNLL
AQALCSWTAK TDNHLNFNKD DVIQVLEQQE NWWLGELKGD QGWFPKTYVT LLGSPSMKGS
PPDESSDSLQ LEVRFSSFYL AEYVAMYTYE SPEPGDLTFR AGDVILVSKR EGEWWNGSVG
DRTGLFPGNY VKPKETDTSS TSGKKKPAEI AQVVRVHSSS GPEQLTLENG QLIVVLGKNA
SGWWLGELQA RGKKRQKGWF PASHVKVLGS NSGKSTPASQ PACQVVALYD YTAANSDEMS
FTTGQIISVL DKNNPDWWKG ELNGVTGLFP TNYVKMAPAD CDHSQYGCAD PSSLDSLSLQ
EKKRQGYIHE LIETEERYME DLQIVLDVFH KPMSESGRLK DSEMAMIFFN WGELLTCNTK
LLKALRARKK AAGENAPVQM IGDVLAAELS HMQPYIRFCS SQINGATLLQ TRIDNEPDFK
NFLKKIATDY RCKGMPLCSF LLKPMQRITR YPLHIKNILE CTAEGHADRL PLKEALERAE
ELCQQVNEGV REKENSDRLE WLQTHVLCEG TAENLAFNSL TNCLGPRKLL HSGKMYKAKS
NKELWAFLFN DFLLLTHTAK QFTSSGLDKL FSNKNNVQLK MYKPPVLLNE VLVKLPDPSS
DEPVFHISHI DRVYILKTEN INERTAWVQK IKAASEEFIE TEKKKREKAY QARSMKATGI
GRLLVTILEA TELKAAKPNG KSDPYCEVTM GAQVFTSRTL NDTLNPKWNF NCQFHIKDIY
QDVLCITIFE RDQFSPDDLL GRTEVPVATI KKESENKGAV TRRLLLHEVP TGEVWVRLDL
QLYGSK
//