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Database: UniProt
Entry: H3DK01_TETNG
LinkDB: H3DK01_TETNG
Original site: H3DK01_TETNG 
ID   H3DK01_TETNG            Unreviewed;      1626 AA.
AC   H3DK01;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   SubName: Full=Intersectin 2b {ECO:0000313|Ensembl:ENSTNIP00000020847.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000020847.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000020847.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   STRING; 99883.ENSTNIP00000020847; -.
DR   Ensembl; ENSTNIT00000021080.1; ENSTNIP00000020847.1; ENSTNIG00000017697.1.
DR   GeneTree; ENSGT00940000155936; -.
DR   HOGENOM; CLU_002819_2_0_1; -.
DR   InParanoid; H3DK01; -.
DR   OMA; CIAINEK; -.
DR   TreeFam; TF324293; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd08375; C2_Intersectin; 1.
DR   CDD; cd00052; EH; 2.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11990; SH3_Intersectin2_2; 1.
DR   CDD; cd11994; SH3_Intersectin2_4; 1.
DR   CDD; cd11838; SH3_Intersectin_3; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 5.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR000261; EH_dom.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR035738; Intersectin-2_SH3_2.
DR   InterPro; IPR035740; Intersectin-2_SH3_4.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR46006:SF6; GUANINE NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12763; EF-hand_4; 2.
DR   Pfam; PF16652; PH_13; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF07653; SH3_2; 3.
DR   Pfam; PF14604; SH3_9; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00027; EH; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 5.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 5.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50031; EH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..1626
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013084872"
FT   DOMAIN          20..108
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          52..87
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          246..335
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          279..314
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          720..781
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          836..894
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          918..976
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          986..1050
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          1060..1119
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          1143..1329
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          1368..1476
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1484..1600
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          966..986
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          367..395
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          431..522
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          557..591
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          619..714
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1626 AA;  182751 MW;  0226A39525828DDD CRC64;
     ILFVSFLLGG SSIWAISPEE RNKHDQKFDT LSPLMGYVSG EQAKKFFLQS GLPASVLAEI
     WALADMNKDG KMDRLEFSIA MKLIKLKLQG TSLPSALPII MKQPPVPAPS LNKPISSMTN
     PAYAPGLATL TPMPGLSPLV TTATGLSPLI TPTPTHPLMP TVGNTTLPNG SMGILQPFPA
     GTLATGLPLG VSPTPSLLDL GSASYLKFHA ASLCRLCSSV SSASSSPAAV SPITAGPSDW
     AVPHASRLKY RQQFNGLDKL MTGYLTGQQV RAAMATTMLS QTQLASIWNL ADVDKDGKLK
     AEEFILAMHL VDLAKSGHAL PLTLPTELVP PSQRTAVNGS VSSLMDDLDI EPPQKAKANY
     TFEDKFKANL ERGNAELEKR RLALQEAERR EQERRAGKDF SRCLAGSRPH LLCPPWVRFQ
     AAQRELERQK KEEWERQRRG ELQKKKQQEQ EDIVRLRAKK KSLELELEAV GNKHRQISDR
     LRDFQNKSKF QRTELDLTNQ RMETRQRDIT SLQKELEDFQ RKLSQLTPEQ KRLTQKLKNM
     ALNNKSVPAV SALKVGVVEK KGTCLKLRQQ LESLEKETAA KLAEMDQYKK DAQCVVAEDS
     MLQAAFCLLS CLRNLFYLLK DLKEREQKQQ AALDKLRGVK EEKRRELMRR KELEAQRTRL
     IKLEKERQWQ EKLRRDEEER QKRIQEEREA KKREEEEKER QALIQAAKEE AERQLRAKSA
     ALTPFKALYP FTARNSEELS FEADDILEVD ETTEREEGWL YGSKQGKMGW FPESYVERVA
     PSDLASSPPA PAPKPSIQSQ LVSALVAAKA VGTKSAFTPT HSTNAAPPDT HGQKVVGNLL
     AQALCSWTAK TDNHLNFNKD DVIQVLEQQE NWWLGELKGD QGWFPKTYVT LLGSPSMKGS
     PPDESSDSLQ LEVRFSSFYL AEYVAMYTYE SPEPGDLTFR AGDVILVSKR EGEWWNGSVG
     DRTGLFPGNY VKPKETDTSS TSGKKKPAEI AQVVRVHSSS GPEQLTLENG QLIVVLGKNA
     SGWWLGELQA RGKKRQKGWF PASHVKVLGS NSGKSTPASQ PACQVVALYD YTAANSDEMS
     FTTGQIISVL DKNNPDWWKG ELNGVTGLFP TNYVKMAPAD CDHSQYGCAD PSSLDSLSLQ
     EKKRQGYIHE LIETEERYME DLQIVLDVFH KPMSESGRLK DSEMAMIFFN WGELLTCNTK
     LLKALRARKK AAGENAPVQM IGDVLAAELS HMQPYIRFCS SQINGATLLQ TRIDNEPDFK
     NFLKKIATDY RCKGMPLCSF LLKPMQRITR YPLHIKNILE CTAEGHADRL PLKEALERAE
     ELCQQVNEGV REKENSDRLE WLQTHVLCEG TAENLAFNSL TNCLGPRKLL HSGKMYKAKS
     NKELWAFLFN DFLLLTHTAK QFTSSGLDKL FSNKNNVQLK MYKPPVLLNE VLVKLPDPSS
     DEPVFHISHI DRVYILKTEN INERTAWVQK IKAASEEFIE TEKKKREKAY QARSMKATGI
     GRLLVTILEA TELKAAKPNG KSDPYCEVTM GAQVFTSRTL NDTLNPKWNF NCQFHIKDIY
     QDVLCITIFE RDQFSPDDLL GRTEVPVATI KKESENKGAV TRRLLLHEVP TGEVWVRLDL
     QLYGSK
//
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