ID H3DL88_TETNG Unreviewed; 1243 AA.
AC H3DL88;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Hemicentin 1 {ECO:0008006|Google:ProtNLM};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000021286.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000021286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H3DL88; -.
DR Ensembl; ENSTNIT00000021521.1; ENSTNIP00000021286.1; ENSTNIG00000018120.1.
DR GeneTree; ENSGT00940000154614; -.
DR HOGENOM; CLU_006445_0_0_1; -.
DR InParanoid; H3DL88; -.
DR OMA; THIFANG; -.
DR TreeFam; TF317514; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 7.
DR CDD; cd00096; Ig; 1.
DR CDD; cd00255; nidG2; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR22906:SF21; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22906; PROPERDIN; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00090; TSP_1; 6.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..70
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 74..161
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 166..251
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 597..818
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 832..871
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 917..954
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 997..1032
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1040..1079
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 836..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 921..931
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1044..1054
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1243 AA; 135571 MW; 856B96CB9BFBCC16 CRC64;
ERLLLACGVN GIPTPHITWV FNNSILPVHY DHANGHSQLV IERVTKEDSG TYTCVAENRV
GTIKSLGFVS ILEPPIIDGD LRSNRIEPLG GNAVLNCEVR GDPPPTIRWS KNGIHITIGD
RIRQLNNGSL AIYGTVSEDA GSYTCVATND AGAVERSVTL TLQRAPTITE EPVGTVVDAG
STVVLNCQAE GEPTPTIEWS QQGRPLLGND RFSSLSNGSL RISSVQKEDT ARYECVARNL
VGSVLARVPL TVRVHGGFSE WAEWGLCTVS CGTGAQKRLR RCNNPLPANG GRRCVGPDTE
TRGCQGKPCP VDGNWSEWSA WEECSRTCGQ GNRTRVRTCT DPPARHGGRL CEGKPVEVIL
CSVRPCPVAG NWGPWLPWSP CSETCGKGMQ TRIRLCNDPP PAFDGPHCDG SDAQTQVCKE
SFCPVDGKWS SWVSWGACAV SCGGGTRQRT RLCASPAPQH GGRQCEGNDV HIDFCNSDPC
PISGNWGPWS NWGSCSKTCN GGQMRRYRTC DNPTPANGGK ACAGGDTQTQ RCSTATCPVD
GSWGSWQLWG ECSASCGGGQ RSRLRLCNSP SPSHSGRPCP GDSSQLSRCS TQPCPGGPQK
ARGNIIGSIN DIDFGIAILN ATMTTSQTGS RVIKATISNI PRTLGPAMRK LVSILNPIYW
TTAQEVGEAA NGYTLTQGIF RRETQVEFAT GEILRMTHIA RGLDSDGGLL LDIVVNGHVL
QLPSHAGIVI KDYTEDYIQT GPGQLYALST RMFSVDRESV PYSWNHTITY DSSKGKMPYL
VEMLRATAIR ADYHPLEEML EYSIQASILK GDRSNQCPHG FSLAPAGPYC ADENECEVGN
PCSHACHNAV GTYHCSCPRG LTISADGRTC QDIDECSLEG HVCHNGQDCE NTIGSYRCVM
RCGRGFRRTA DGLSCTDINE CQESHPCHQH CLNTVGSYRC ACEPGFYLRN RRCIDINECR
QRVCRLDQQC RNTRGGYSCI DLCPSGLTKA ANATCVDIDE CRDGTHQCRY NQVCENTRGS
YHCTCPRGYR SQGVGRPCVD INECEAKDVC QHECVNTPGS HRCLCPAGYR LMANGKTCQD
IDECLEEKIQ CGANQMCFNM RGSYQCTETP CPPNYQRDPT TGFCLKNCPP NDLECALSPY
AVEYKLLALP FGIAANQDLI RLVAYTQDGV MHPRTTFLGV DEDATLPFAL RDENMKGVLF
TTQALREPRT YRMKVRALSY SPDGGIEYQT TFIVYIAVSI YPY
//
