ID H3DMI5_TETNG Unreviewed; 2412 AA.
AC H3DMI5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Notch receptor 3 {ECO:0000313|Ensembl:ENSTNIP00000021733.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000021733.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000021733.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 99883.ENSTNIP00000021733; -.
DR Ensembl; ENSTNIT00000021968.1; ENSTNIP00000021733.1; ENSTNIG00000018559.1.
DR GeneTree; ENSGT00940000160234; -.
DR HOGENOM; CLU_000576_0_0_1; -.
DR InParanoid; H3DMI5; -.
DR OMA; HGTCHDD; -.
DR TreeFam; TF351641; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 28.
DR CDD; cd21704; JMTM_Notch3; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 34.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022331; Notch_3.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00008; EGF; 20.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01986; NOTCH3.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 35.
DR SMART; SM00179; EGF_CA; 31.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 7.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 33.
DR PROSITE; PS01186; EGF_2; 29.
DR PROSITE; PS50026; EGF_3; 35.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS50258; LNR; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..12
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 13..53
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 54..90
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 92..129
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 131..168
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 170..206
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 208..246
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 248..284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 285..323
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 325..363
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 365..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 403..439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 441..477
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 479..514
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 516..552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 554..589
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 591..627
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 629..664
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 666..702
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 704..740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 742..780
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 782..818
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 820..856
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 858..894
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 896..932
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 934..970
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 972..1009
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1022..1057
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1059..1095
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1097..1133
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1135..1179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1181..1219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1221..1260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1261..1297
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1300..1338
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1351..1391
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1426..1469
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1795..1827
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1862..1894
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1895..1927
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1928..1960
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1990..2050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2265..2412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2265..2288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2289..2305
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2315..2343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2360..2403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 345
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 348
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 365
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 368
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 382
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 420
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 2..11
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 43..52
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 80..89
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 119..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 158..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 196..205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 236..245
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 274..283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 294..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 313..322
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 329..342
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 336..351
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 353..362
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 369..380
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 374..389
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 391..400
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 407..418
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 412..427
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 429..438
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 467..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 483..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 504..513
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 542..551
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 558..568
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 579..588
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 617..626
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 633..643
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 654..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 692..701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 730..739
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 751..768
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 770..779
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 808..817
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 846..855
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 884..893
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 922..931
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 960..969
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 999..1008
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1047..1056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1085..1094
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1123..1132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1169..1178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1190..1207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1209..1218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1250..1259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1287..1296
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1309..1326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1328..1337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2412 AA; 259600 MW; C639D3E9DA3B8821 CRC64;
RCRPGFIGPF CQYLDPCQRS PCLNGAACKS QMVNGVPQYS CVCQRGFRGQ DCSLIDACAT
SPCANGARCA NSKNHYNCSC PPGFQGKNCR NDIDECRKPG ACLNGGLCMN THGSFRCQCP
PGYSGRTCEV STLPCAPSQC LNGGTCRQIS DHSYECACLP GFEGHNCENN VDDCPGHKCM
NGGKCVDGVN TYNCQCPPEW TGQYCAEDVN ECLMQPNACH NGGTCFNTIG GHTCVCVNGW
TGDDCSENID DCATAVCFNG ATCHDRVASF FCECPVGKTG LLCHLDDACV SNPCNEGAVC
DTNPLNGRAI CTCPAGFVGG ACNQDMDECS IGANPCEHFG KCVNTEGSFQ CQCGRGYAGP
RCEIDINECL SMPCQNDATC LDRIGEFTCI CMPGYMGTYC EVDIDDCESN PCVNDGICRD
IVNGFKCTCQ PGFTGSMCQI DIDECASTPC QNGAKCYDRP NGFECRCAEG YEGTLCESNI
NNCQPDPCHH GTCIDGIASY TCSCDPGYTG YRCENQLNEC HSNPCQNGGK CVDLVNKYMC
QCQHGTSGTN CEINFDDCAS NPCDYGICKD GINRYDCVCK PGFTGPKCNV EIDECASSPC
RNGGTCVDKE NGFHCQCPEG FKPPYCYSQV DECASSPCVH GSCRDDINGY RCDCEPGWVG
KNCDLDRNDC LPSPCQNAGT CIDQLNGFTC KCRQGFRGNL CQVNINECGS SPCLNKGTCV
DGAASFTCLC ELPYSGPTCA EVLTPCSPNP CANHAVCSHT PDYLGYQCNC QPGWQGQLCN
IDVNECISNP CKNRGTCTNT PGGFLCSCRA GFTGLTCETD INDCSPNPCL NGGSCIDDVN
SFHCSCLAGF TGQRCAVEIN ECQSSPCENG GTCTDYVNSY TCTCRPGFTG IHCETNIPDC
TESSCFNGGT CTDKINGYSC TCRPGFTGSH CQYEVNECDS QPCLNGGICQ DALESFRCSC
PKGFFGNRCQ TPVDWCRRSS PCQNGGRCRQ KDASFACECT HGWSGRYCDI RRVSCETAAR
QRGIQTDELC HHGGHCVNTG NTHYCKCPDD YTGSYCESQV DHCEDKPCHN GATCRGYVGG
YQCDCMPGYT GQNCEIEINE CQSHPCQNGG SCIDLVGHYI CSCPPGTLGV LCEINEDDCA
PPPGVHGASP KCLNNGTCVD RVGGYRCNCP PGFTGERCEG DINECLSNPC NPSSSLDCIQ
LPNDYRCVCK PGFTGRRCQS RFSVCESQPC QNGGACSVSS ISASGYICTC QLGYSGANCE
RSMSCRELPC YNGGSCTITA RGARCTCLKG FGGPQCQHRS NEGCSSKPCR NDGLCTEETA
FPYFHCQCQS GWTGKRCEKG VAALEPQAPS CPLAECHDKA NNSVCNKECN TLPCHWDGGD
CSLTVNPWSS CAHCYRSFNN SQCDDSCNNA ECLYDNFDCK AKEKVCNPIY ETYCIDHYAD
GQCDQGCNTE ECGWDGLDCA GKVPENLANG VLVLVVLLPP EELLRSSTAF LQKLSVILRT
TLRFRLDKNG EAMIRPFTRK EARLKRELQP HEEVIGSIVY LEIDNRLCSE TCFPTADTAA
KYLGALSASE MLHFPYPLKE VRGESIEDFP PIPEWAKLML VAIASLFLLI ILMIGMLITR
RKREHSTLWF PEGFFLKKEP SSNKNRREPV GQDALGMKHM AKTVEESLLG DHSDQWTDSD
CPEAKRIKVE EPSMLSDSED AVDSRQWTQH HLAAADIRVP PTMALTPPQG EFEGDCMDVN
VRGPDGFTPL MLASFCGGGF EPEVAEDEEN EECSAHIISD LIYQGASLAA QTDRTGETAL
HLAARYARAD AAKRLLDAGA DANAQDNTGR TPLHAAVAAD AQGVFQILIR NRATDLDSRM
YDGSTALILA ARLAVEGMVE ELITCHADVN AVDELGKSAL HWAAAVNNVD ATIALLKNGA
NKDMQDLKEE TPLFLAAREG GCEAVRVLLA HFANREITDH MDRLPRDIAQ ERMHHDIVQL
LDEYNTVRSP QGHGGAGHHL TGGHTLSPLM CPPSSFLPNL KTTPQGKKNR RPGAKGSSLG
GQHATSLKES VKARNKKLTL EMQNALLESS VTLSPVDSLD SPHGGATNAG YITNPTSPVA
MQSPGLFHSS MSVPNTPMVH NSMLEGGGPF AVSLAQLGDP GAGGMSMQGR ISMASDVNHG
YVLSSGQVGL NMGMVSPVSV PFDWHSRMPP SSQCAQPVVN LIQNSQAAMH PQSPVMQQQS
MLMHQPQMFR STMLQPTPVT STPSISPVKL PSIALTHQAI TNQQSMARMS TSTPPTPQTS
QAPRPFSQMP QQPSQPQPPA QLPQAAPSAA QPAPALPSQP SVSTAGTEDY PTPPSQHSYS
SALDATPKHY LHLPSEHPYL TPSPESSEPW SSPSPHCVSD WSDSTPSPAV AGPAQTQITQ
VPEAPGKMQM FA
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