ID H3DNF8_TETNG Unreviewed; 3238 AA.
AC H3DNF8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Dynein, axonemal, heavy chain 2 {ECO:0000313|Ensembl:ENSTNIP00000022057.1};
GN Name=DNAH2 {ECO:0000313|Ensembl:ENSTNIP00000022057.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000022057.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000022057.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 99883.ENSTNIP00000022057; -.
DR Ensembl; ENSTNIT00000022293.1; ENSTNIP00000022057.1; ENSTNIG00000018872.1.
DR GeneTree; ENSGT00940000157623; -.
DR HOGENOM; CLU_000038_0_1_1; -.
DR InParanoid; H3DNF8; -.
DR OMA; ILKNDMQ; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF32; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 560..696
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 839..975
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1205..1351
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1825..1859
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2031..2093
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2344..2371
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3238 AA; 368387 MW; FB37EBC084233DF5 CRC64;
KVWEVTVDWN KNWDVWKVGQ FTTLQTESME STTQELFKSL QKLQRELKDK QWEIIDFCKA
KIDQFRKILP LIVNLKNPAM RDRHWQEIGL HLHCTIEPSS PEFTLEKIIF LGFDLHAEKI
CEVSGAASKE LSIEQGLGNI QSTWEKIFLD VEPYKDEGHY WLRGTEEVFQ ALEDNQVVLS
TMKASHFVRA FEKEVDCWER RLSLVMEVIE MILMVQRQWI YLENIFRGKD IREQLPRECR
EFQEASGTWK VVMSRLYKDN RALEGTHHPG LLEKLTAMNI KLEEIQKALD LYLETKRQIF
PRFYFLSNDD VLEILGQSQN PQAMQPHLKK CFDNIKSLRA NKKQVATGMF SADGEFVPFN
KAVSLDSPVE LWLCDVEKIM RSTLKDILFR CLNALKKASA HREKWLTEWP GQMVITASQI
QWTTNVTKAL LTCKEREDNA ALKSIKRKQV SMLHGYSEII RGNLSKVQRL KIVALVTVEV
HARDVIDKLA KASCRDTNAF DWLSQLRLYW EKDENDCIIR QTNTHFKYGY EYLGNSGRLV
ITPLTDRCYM TLTTALHLNR GGSPKGPAGT GKTETVKDLG KALGMYVIVV NCSEGLDYKS
MGRMFSGLAQ TGAWVCYDEF NRINIEVLSV VAQQILSILS ALAARQTKFH FEGYYIRLVS
TCGIFITMNP GYAGRTELPD NLKSMFRPIS MVVPDSTQIA EILLFAEGFD NCKLLAKKVF
TLYSLAMQQL SKQDHYDFGL RALTSLLRYA GKKRRSCAGV PNEEVLLMAM KDMNIAKLTS
TDLPLFNGIT QDLFPAVETP VIDYGMLEQV IKAELRGCGL QVTPFTMTKV IQLYETKNSR
HSSMLVGKTG CGKSVTWKIL QLALTAMHRQ AEPGFQTVQV FPINPKSMSL GELYGEYDLS
TNEWTDGVLS SIMRAACADE SPDEKWIMFD GPVDTLWIES MNSVMDDNKV LTLINGDRIS
MPEQVSLLFE VENLAMASPA TVSRCGMVYN DYTDLGWKPL VQSWLDQRHK AVTMYPQEEA
EHLNPLFDKY IESTLSFKNS NCRELIPITE LNGVISLCRL YDSLATPENG VKTSDREHLG
TIVELWFTFS LIWSICASVD EIGRQKIDTF LREKDGTFPV NIKELFGGRH LNTADTAANG
RFCPFIAADT VYEYYVDTKK KTWVPVEDRL PKGWRYNACD PFYKIMVPTV DTERYKFLVN
ALVMAHYPVL LSGPVGTAKT SVAQSVLQGL SERWTGLTIN MSSQTTSNNI QAIVESRTEK
RTKGEFVPVG GKRLLCFLDD LNMPANDLFG SQPPLELLRL WIDYGFWFDH QKQTKKFIKD
MFLLAAMGPP GGGRTYISGR LQSRFNLINM TFPNESQIRR IFSTMINQKL EVFREEVKPL
GEILAQATLD LYFSVSAHFL PTPSKIHYLF NLRDISKVFQ GLLRAHPDYH ENKVDITRLW
IHECFRVFSD RLVDHKDLEE FVALLEKTLT SHFDLQFDSI CPSLHIKQNE TVRYCGLYTG
SCGTGDFLNE TSVYEDLQDR DNLKRFMQTQ LQDYSETPGL VPMNLVLFQD AIEHVTRTVR
VISQLRGNML LVGVGGSGRQ SLSKMAAFIC EYKVYQVEIT KHYRKQEFRE DIKQLYRLAG
VDSKPTVFLF NDTQIVDESF LEDINNILSS GEVPNLYKPD EFVEICNALA DSAKRDNVLQ
TPDSMFSYLI ERVRNNLHVI LCMSPVGELF RQRLLQYPAL VNCTTIDWFC EWPRDALLEV
AERFLDGLDL GSTEGIHTNV ASTFVTIHQS VAQMSLKMRL DVRRYNYVTP TNYLELVSGY
KKLLAEKSLE LGEQVNKLCN GLLKISDTRE KVEGMTVELE EAKKQVAEFQ KQCEEYLTVI
LEQKREADRH QKVVSEDREK IRAEEVQCKE MAANAQKDLD EALPALEEAL MALESLNKKD
MTEIKSYGRP PALVETVMQA VMILLGKDPS WAEAKKQLGD SNFIKTLINF DKNNISQRVL
KRIGQFCMLA DFQPDVIGKV SLAAKSLCMW VRAMEVYGRI YRIVEPKQAL LQAATTQLEE
KQAALAAAQD KLQEVDRTLK QLKDQHAEKL LIKENLRKKS EDMETKLDRA DKLVTGLAGE
RIRWENTVGG LKENVGYLVG DCLLAASFLS YMGPFLSEYR DELLAIWMTQ VQKLEIPCTP
GFSFAVFLSK PTTVRDWNIQ GLPSDSFSTE NGVIVTRGNR WPLMVDPQGQ AMKWIKSMEM
DKGLKVIDFQ MPDYLQVLEN AIQFGNPVLL QNVQEELEPS LNPVLNKSLT RIGGRLLMKL
GDKEIEYNPE FCFYITTKLP NPHYSPETCT KTTIVNFAVK EQGLEAQLLG TVVREERPDL
EEQKDNLVIS IASGRKQLQE LEDEILRLLN EATGSLLDDV QLVNTLQTSK VTATKVTQQL
ETSEQTEAMI DSAREGYRPC AQRASILFSI LNNLSSMDPM YQFSLDAYVN LFKLSISKSK
RSHKLEERIA NLNSYHTYAV YRYTCRGLFE IHKLLFSFQM CVRIMETAGK LDMNEYNFFL
RGGIVLDKEE QMENPCSGWL VNSSWDNITV LEELPGFQGI MASFEAYPEE WKLWFTSSEP
EKTALPGDLE GKFNNLQKML IVRSLRQDRV TFCVTSFIID NLGVSFVEPP ALDMKAVVEE
SSCRTPLIFV LSPGVDPTGA LLQLAETSGM KDDFQALSLG QGQAPIARKM IGEGVRNGHW
VFLANCHLSL SWMPELDKLV EQLQVEQPHP NFRLWLSSSP HPDFPITILQ SGIKLTTEPP
KGVKANMKRL YQLVKDDNFE CCSRPGFYKK LLFSLCFFHS ILLERKKFLQ LGWNIVYGFN
DSDFEVSESL LSLYLNEYEE IPWDALKYLI AGVNYGGHVT DDWDRRILTT YINDCFCDEA
VNQPLYKLSC LPSYYIPDDG PLPSYLEYIN GLPPTEHPEV FGQHFNADIA SQIAEARMLF
DTMLALQPQT SGAAAAGGGL TREDKVLGLL GDIRGMIPAP MDMEKPSSML QDDPSPLNVV
LTQEIQRYNV LLDIIISSLV ELEKGIKGLV VMSSNLEETF TSIHDGRVPP LWEKAYPSLK
PLAAWTRDLC QRVGQFQLWA GTSQPPRLFW LSGFTFPNGF LTAVLQSYAR QQNISVDTLS
WDFTVSSGDD DSALEAPKEG VLIQGLFLEG AGWDRKNLCL VEAEPMQMVS AMPAIHFRPV
ERKKSNKSMY ACPCYYFPVR SGGAGRASFV VSVELKSGAV SQDHWIKRGT ALLMSLDH
//
