GenomeNet

Database: UniProt
Entry: H3DNV5_TETNG
LinkDB: H3DNV5_TETNG
Original site: H3DNV5_TETNG 
ID   H3DNV5_TETNG            Unreviewed;      4930 AA.
AC   H3DNV5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-NOV-2017, entry version 40.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSTNIP00000022204};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000022204, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000022204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000022204}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000022204}.
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DR   Ensembl; ENSTNIT00000022442; ENSTNIP00000022204; ENSTNIG00000019014.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4237   4257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4451   4471       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4534   4556       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4673   4694       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4732   4752       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4811   4834       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      212    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      586    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1341   1553       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4930 AA;  558860 MW;  7E1995376C3C108F CRC64;
     MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICTFILE QSLSVRALQE MLANTVEMTE SSQGGGHRTL LYGHAILLRH NHSAMYLSCL
     TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWN MNPISSGCEL AEGFLTGGHV LRLFHGHMDE CLAIATPEEG
     EEKRRMAHYE GGSVCSQARS LWRLEPLRIS WSGSHMKWGQ SFRIRHITTG RYLCLDEEKG
     LLVVDPERAD TKHSAFCFRA SKEKVDVAQK RDVEGMGIPE IKYGESMCFV QHVSTGLWLT
     YAALDAKAAR LGMMKRKVIL HQEGHMDDAL TVSRSQTEES QAARMIYSTV GLFRQFIKGL
     DTLTGKNKSP GAVALPLEGV ILSLQDLIFY FRPPDEELEH EEKQTKLRSL RNRQNLFQEE
     GMITIVLECI DRLNVYNTAA HFSEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFT
     NLDWLVSKLD RLEASLSILE VLYCVLIESP EVLNIIQENH IKSIISLLDK HGRNHKVLDV
     LRSLCVCNGV AVRSNQNLIT ENLLPGRDLL LQTNIVNYVT SVRPNIFLGT CEGSTQYKKW
     YYEVMVDHVE SFVTQQATHL RVGWAMTDGY SPYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGTVPRQVAS PSAHTLAADD VVSCCLDLSV PSISFRINGH PVQGMFENFN VDSLFFPVIS
     FSAGVKARFL LGGRHGDFKF MPPPGYAPCY EALLPRERMR IEPIKEYKHD FSGVRNLLGP
     TLSLTHTSFT PCPVDTVQIV LPPHLERIRE KLAENIHELW AITRIEQGWT YGVFRDDNKK
     LHPCLVDFQS LPEPERNYNL QMSGETLKTL LALGCHVGMG DEKAEENLKK IKLPKTYVMS
     NGYKPAPLDL SHVRLTPNQN QLVEKLAENG HNVWARDRVR QGWTYSIVQD ILNKRNPRLV
     PYVLLDEKTK KTNRDSVNNA VRTLIGYGYN IEPPDQESTG HGLENTRGDK VRIFRAEKSY
     AITQGKWYFE FEAVTTGEMR VGWARPNVRS DTELGADELA YVFNGNKAQR WHIGNEPFGR
     QWQSGDVVGC MIDLTEMNIM FTLNGEMLIS DSGSEMAFKD IEIGEGFIPV CTLGLSQVGR
     INLGQNVSSL RYFAICGLQE GFEPFAINMK RDTTMWFSKS LPQFVPVPTD HNHIEVSRVD
     GTVDSAPCLK LTHKTYGSQN ANTDMLFLRL SMPIQFHTTF KIPAGTTPLT RALNIPEDIA
     VVEPDSEFEV LKKSASRKEQ EEDKKEPSVP KEVLAENEKD TVSEKGKKRG FFSKAKKAAM
     TPLAPPPAPP TVPRLVEDVV PDDRDDPEII LSTTTYYYSV RIFAGQEPSG VWVGWVTPDY
     HQYDQTFDLS KVRSVTVTVG DDKGNIYNSM KHSNCYMVWG GDLVSNHQTR FSQEDMVIGC
     LVDLATGLMT FTANGKEINT FYQVEPNTKL FPAVFIQPLS QNLVQLELGK LKNIMPISAA
     MFRSERNNPV PQCPPRLDVQ MLTPVIWSRM PNRFLNPEVG RVSERLGWVV ECTEPLIMMA
     LHIPEENRCI DILELSERQD LMKFHYHTLM LYCAVCALGN NRVAHALCSH VDESQLFYAT
     ENTYLPGPLR SGYYDLLISI HLESAKRARL GTNREFIVPM TEETLSIKLY PDAVKAHSLP
     GVGLTTCLRP KLHFSSINFV GTDPDLYTLS PVFPLQELKT RAISMLTEAV LDGSQAMRDP
     VGGSVEFHFV PILKLINTLL IMGIFNDEDT KHILKMIDPN VFSGKDEEED TEKPTEGGTA
     EDDKAKEEES EEAAELLQMK LPESVKLQMC TLLQFFCDCE LRHRVEAIVA YSDKFVHDIQ
     DNQRIRYNQL MRAFTMSAAE TARKTREFRS PPQDQVLLLT NFKHSLEDEE CPVPDDVRDT
     LKEFHNDLLL HCGIHIEEEA VEEEVDTSLR GRLLSLVDKI KSLRGKKTEE KPEVEEETKP
     STLQELISHT MIHWAQESFI QNPELVRLMF SLLHRQYDGL GELIRALPKA YAINAVSVQD
     TMDLLECLGQ IRSLLIVQMG PEEERLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM
     VNVLGGGDSK EIRFPQMVTN CCRFLCYFCR ISRQNQRSMF DHLSYLLQNS SIGLGMRGST
     PLDVAAASCI DNNELALALQ EQDLEMVVMY LASCGLQMCP MLLSKGYPDI GWNPCGGERY
     LDFLRFAVFV NGESVEENAN VVVRLLIRRP ECFGPALRGE GGNGLLAAME EAIKISEDPA
     RDGPTVKKDR RFMFGGEEQQ EENRVHLGNA IMSFYSALID LLGRCAPEMH LIQAGKGEAL
     RIRAILRSLV PIEDLVGVIS LPVQIPSYGK DGQIIEPKMS ASFVPDHKAS MVLFLDRVYG
     IDNQDFLLHV LEVGFLPDMR ASASLDTVAF STTEMALALN RYLCSAVLPL LTKCAPLFAG
     TDHRAIMIDS MLHTIYRLSR GRALTKAQRD VIEECLMSLC KYLRPSMLQH LLRRLVFDVP
     ILNEYAKMPL KLLTNHYERC WKYYCLPNGW ANFGVTSEEE LHLSRKLFWG IFESLAHKKF
     DAELFKIAMP CLCAIAGAIP PDYVDASYSS HTEKKASVDA EGNFDPKPVE TTNTIIPERL
     DTFINKYAEH THDKWAFEKI QNNWTYGEVL DENAKTHPML RPYKTFSEKD KEIYRWPIKE
     SIKAMLAWEW TLEKARDGEG EVEKKAATRK ISQTAQATYD PSHGYSPQPI DISGMALSRE
     LQSMAEQLAE NYHNTWGRKK KLELQSKGGG THPLLVPYDT LTAKEKARDR EKAQDLLKFL
     QLNGYAVTRG MKDMEQDISS IEKRFAYGFL QKLLKWMDIA QEFIAHLESE AVVSSGRVEK
     SPHEQEIKFF AKILLPLVNQ YFKNHCLYFL STPAKVLGSG GHSSNKEKEM IASIFCKLAA
     LVRHRVSLFG TDAGAVVNCL HILSRSLDAR TVMKSGPEIV KAGLRQFFES AADDIEKMVE
     NLKLGKVSSR NQVKGVSQNI NYTTIALLPV LTSLFDHIAQ HQFGDDVILD DLQISCYRIM
     CSIYSLGTVK TPHAEKQRPA LGECLAHLAA AMPVAFLEPV LNEFNMFSVY TTKTPRERTI
     LGLPNQVEEL CPDIPELEVL MKDIHDLAES GARYTEMPHV IEITLPMLCN YLPRWWERGL
     ENFPEQEGQL CTSVTSEQLN QLLGSIMKIV VNNLGIDEAS WMKRLAVFAQ PIVSRAKPEM
     LKSHFIPTME KLKKRSGKVV AEEDHLRMEG KTEVDSENGT IRDEFAVLCR DLYALYPLLI
     RYVDNNRARW LTNPDPDAEE LFRMVGEVFI FWSKSHNFKR EEQNFVVMNE INNMSFLTAD
     SKSKMSKSGG SEQERTKKKR RGDRYSVQTS LIVAALKKLL PIGLNMCSPA DQELINLAKI
     RYSLKDTDEE VREFLHNNLH LQGKVEDPAM RWQMSLYKEM AGKAEDAEDP EKVVKRVQEV
     SAVLYHIEVT EHPFKSKKMV WHKLLSKQRR RAVVACFRMT PLYNIITHRA TNMFLDAYKR
     NWLETEGYSF QDKMIDDLSV SSDHSNEMSS RKERKPDPLH QLILHLSRTA LTEKTKLDVD
     HLYKNYAEIM AKACYITFST GASSFERFQR SSSSSASQEK EMEIQRLLYQ QSRLHNRGAA
     EMVLQMISAC KGEPGAMVSS TLKLGISILN GGNSDVQQKM LDYLKDKKDV GFFLSVQSLM
     QTCSVLDLNA FERQNKAEGL GMVSEEGTSL SSTDSHEIPG LTVSLFGFLS PSFALHAAVQ
     QNRLMHPDPG QRTGVRICVI FMPCHVFHLS KTLSHLHFLT LPKSLTATGN SFLLCWCRFF
     RNACSNSTNV IVHAHLFVTL TELYFCFAVF FLTFLQDSSQ IGLLKELLDL QKDMVVMLLS
     LLEGNVVNGT IAKQMVDMLV ESSSNVEMIL KFFDMFLKLK DIVASDAFRD YVTDPRGLIS
     KKDFSKAMDS QKQYTPGEIQ FLLSCSEADE NEMINFEEFA DRFQEPAKDI GFNIAVLLTN
     LSEHVPHDTR LQNFLEQAES VLNYFRPFLG RIEIMGASRK IERIYFEISE ANRNQWEMPQ
     VRESKRQFIF DVVNEGGESE KMEMFVNFCE DTIFEMNIAA SISEPEGDDG NGEEQAPEST
     SAFADFIKSV VNFFNMFTFR NLRRRYRRFR KMTVKEMVIG LVTFVYTVLM GILMFVYSIC
     KGFFTLIWKV LFGGGLVESA KKMTVTDILA SMPDPTQDEV HGELPPEPGS REVQDTEGGA
     DLLDPVGGEE EEEDSEEREG GRLPGFNTPG GLGDFGETTP EEPPTPEGTP LLKRKLLSVS
     FMSSTENGEK AEKEPEPEPE PKEEEPAEKE EAAVKTKAKK SKKPVEEGFE LWNELEIQRV
     KFMNYLSRNF YNLRFLALFI AFAVNFILLF YKVSDSPPGE EDFEGSGLFE GSGLFEGSGA
     PEDGSGFDDG GEDDEEEGPL YYFLEESTGY MEPAMAFLSI VHTIISFLCI IGYNCLKVPL
     VIFKREKELA RKLEFDGLYV TEQPEDDDIK GQWDRLVLNT PTFPNNYWDK FVKRKVLDKY
     GDIYGRERIA ELLGMDLASL DVSAMTHEKK PEPDTSMFSW ITSIDVKYQI WKFGVVFTDN
     TFLYLVWYLL MSILGHYNNF FFAAHLLDIA MGVKTLRTIL SSVTHNGKQL MMTVGLLAVV
     VYLYTVVAFN FFRKFYNKSE DEDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD
     EYELYRVVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGSDY
     FDTTPHGFET HTLEEHNLAN YMFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC
     FRKQYEDQLG
//
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