ID H3DPR0_TETNG Unreviewed; 1154 AA.
AC H3DPR0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Glutamate receptor, metabotropic 1b {ECO:0000313|Ensembl:ENSTNIP00000022509.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000022509.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000022509.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; H3DPR0; -.
DR STRING; 99883.ENSTNIP00000022509; -.
DR Ensembl; ENSTNIT00000022748.1; ENSTNIP00000022509.1; ENSTNIG00000019307.1.
DR GeneTree; ENSGT01030000234595; -.
DR HOGENOM; CLU_005389_0_1_1; -.
DR InParanoid; H3DPR0; -.
DR OMA; CWYAPVA; -.
DR TreeFam; TF313240; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR CDD; cd15449; 7tmC_mGluR1; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001256; GPCR_3_mGluR1.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF29; METABOTROPIC GLUTAMATE RECEPTOR 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01051; MTABOTROPC1R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 599..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 817..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 597..859
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 881..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 128941 MW; 72FECA0CDB1DCCE4 CRC64;
VSSMIPLTAI IVLYSPVLLF EAFALSKGKY ERSVVPSSAS RLVARMDGDI IIGALFSVHH
QPSAEKVAER KCGEVREQYG IQRVEAMFHT LDRINSDPNL LPNITLGCEI RDSCWHSSVA
LEQSIEFIRD SLISIREDSG GSRWCIEGEP SSQPPPTKKP IVGVIGPGSS SVAIQVQNLL
QLFNIPQIAY SATSIDLSDK TLFKYFLRVV PSDTLQARAL LDIVKRYNWT YVSAVHTEGN
YGESGMEVFK ELASQDGLCV AHSDKIYSNA GEKHFDRLLR KLRERLPKAR VVVCFCEGMT
VRGLLMAMRR LGVAGEFLLI GSDGWADRVE VVEGYEQEAV GGITVKLQSE EVSSFDDYFL
KLRLGTNTRN PWFPEFWQHR FQCRLPGHPQ ENRNYARNCS GYESLEDNYV QDSKMGFVIN
AIYAMAHGLH DMHTHLCPGH LGLCENMKPV DGSHLLDFLL KTSFTGVSGE DIWFDENGDS
PGRYEIMNFQ HVSPGVYDYI NIGSWHEGLL SLDEEMIQMN RSDMVRSVCS EPCSKGEIKV
IRKGEVSCCW ICTACKDNEY VQDEFTCKAC ELGWWPDKEL EGCELIPVHY LEWSNPESII
QVVFSCMGIL VTSFVAFIFV LYRDTPVVKS SSRELCYIIL AGIFLGYLCP FTLIARPTVA
SCYLQRLLVG LSTAMCYSAL VTKTNRIARI LAGSKKKICT RKPRFMSAWA QVVIASILIS
LQLSLEVTLI ILEPPEPIKS YPSIREVFLI CNTSNMGVVA PLGYNGLLIM SCTYYAFKTR
NVPANFNEAK YIAFTMYTTC IIWLAFVPIY FGSNYKIITT SFSVSLSVTV ALGCMFTPKM
YIILAKPERN VRAFTTSDAV RMFGDGKIAC RSNSLLNMFK RKKNSGNGSS NGKSVSWSEP
GARHPPKGDH MWHRLSVHVK RQESGSNQMA VIKPLTNTYQ NRLEFSNLST KTLYNVAEED
ESETPGIMPR HSPRVAPEPV PPVCCSKTHR GGELYTPERL QPSNPQVAEM PASFSHDVPE
FNDRMSVPEA MSAPAYRQAH LIQQDPVLAV HLHPYSQEHR SPLQEELENE QLGLLRGYLF
HSNSLTPDEE DSAGARSAME DSLALMPPSP FRDCVCPPVS PFSNSPMSES ILCGPLNATY
TSAVLGDFKQ SSST
//