GenomeNet

Database: UniProt
Entry: H3DPR0_TETNG
LinkDB: H3DPR0_TETNG
Original site: H3DPR0_TETNG 
ID   H3DPR0_TETNG            Unreviewed;      1154 AA.
AC   H3DPR0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   SubName: Full=Glutamate receptor, metabotropic 1b {ECO:0000313|Ensembl:ENSTNIP00000022509.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000022509.1, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Proteomes:UP000007303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000022509.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC       {ECO:0000256|ARBA:ARBA00007242}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; H3DPR0; -.
DR   STRING; 99883.ENSTNIP00000022509; -.
DR   Ensembl; ENSTNIT00000022748.1; ENSTNIP00000022509.1; ENSTNIG00000019307.1.
DR   GeneTree; ENSGT01030000234595; -.
DR   HOGENOM; CLU_005389_0_1_1; -.
DR   InParanoid; H3DPR0; -.
DR   OMA; CWYAPVA; -.
DR   TreeFam; TF313240; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR   GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR   CDD; cd15449; 7tmC_mGluR1; 1.
DR   CDD; cd06374; PBP1_mGluR_groupI; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR001256; GPCR_3_mGluR1.
DR   InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR   InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   PANTHER; PTHR24060:SF29; METABOTROPIC GLUTAMATE RECEPTOR 1; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF10606; GluR_Homer-bdg; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01051; MTABOTROPC1R.
DR   PRINTS; PR00593; MTABOTROPICR.
DR   SMART; SM01229; GluR_Homer-bdg; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        599..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        634..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        667..688
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        709..732
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        758..777
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        789..811
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        817..836
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          597..859
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   REGION          881..910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          960..980
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        881..897
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1154 AA;  128941 MW;  72FECA0CDB1DCCE4 CRC64;
     VSSMIPLTAI IVLYSPVLLF EAFALSKGKY ERSVVPSSAS RLVARMDGDI IIGALFSVHH
     QPSAEKVAER KCGEVREQYG IQRVEAMFHT LDRINSDPNL LPNITLGCEI RDSCWHSSVA
     LEQSIEFIRD SLISIREDSG GSRWCIEGEP SSQPPPTKKP IVGVIGPGSS SVAIQVQNLL
     QLFNIPQIAY SATSIDLSDK TLFKYFLRVV PSDTLQARAL LDIVKRYNWT YVSAVHTEGN
     YGESGMEVFK ELASQDGLCV AHSDKIYSNA GEKHFDRLLR KLRERLPKAR VVVCFCEGMT
     VRGLLMAMRR LGVAGEFLLI GSDGWADRVE VVEGYEQEAV GGITVKLQSE EVSSFDDYFL
     KLRLGTNTRN PWFPEFWQHR FQCRLPGHPQ ENRNYARNCS GYESLEDNYV QDSKMGFVIN
     AIYAMAHGLH DMHTHLCPGH LGLCENMKPV DGSHLLDFLL KTSFTGVSGE DIWFDENGDS
     PGRYEIMNFQ HVSPGVYDYI NIGSWHEGLL SLDEEMIQMN RSDMVRSVCS EPCSKGEIKV
     IRKGEVSCCW ICTACKDNEY VQDEFTCKAC ELGWWPDKEL EGCELIPVHY LEWSNPESII
     QVVFSCMGIL VTSFVAFIFV LYRDTPVVKS SSRELCYIIL AGIFLGYLCP FTLIARPTVA
     SCYLQRLLVG LSTAMCYSAL VTKTNRIARI LAGSKKKICT RKPRFMSAWA QVVIASILIS
     LQLSLEVTLI ILEPPEPIKS YPSIREVFLI CNTSNMGVVA PLGYNGLLIM SCTYYAFKTR
     NVPANFNEAK YIAFTMYTTC IIWLAFVPIY FGSNYKIITT SFSVSLSVTV ALGCMFTPKM
     YIILAKPERN VRAFTTSDAV RMFGDGKIAC RSNSLLNMFK RKKNSGNGSS NGKSVSWSEP
     GARHPPKGDH MWHRLSVHVK RQESGSNQMA VIKPLTNTYQ NRLEFSNLST KTLYNVAEED
     ESETPGIMPR HSPRVAPEPV PPVCCSKTHR GGELYTPERL QPSNPQVAEM PASFSHDVPE
     FNDRMSVPEA MSAPAYRQAH LIQQDPVLAV HLHPYSQEHR SPLQEELENE QLGLLRGYLF
     HSNSLTPDEE DSAGARSAME DSLALMPPSP FRDCVCPPVS PFSNSPMSES ILCGPLNATY
     TSAVLGDFKQ SSST
//
DBGET integrated database retrieval system