GenomeNet

Database: UniProt
Entry: H3DQB9_TETNG
LinkDB: H3DQB9_TETNG
Original site: H3DQB9_TETNG 
ID   H3DQB9_TETNG            Unreviewed;      4945 AA.
AC   H3DQB9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSTNIP00000022718};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000022718, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000022718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000022718}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000022718}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSTNIT00000022958; ENSTNIP00000022718; ENSTNIG00000017023.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 8.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4259   4282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4483   4504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4551   4570       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4697   4722       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4745   4767       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4788   4806       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4826   4849       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    214       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      222    277       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      283    338       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      348    405       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      602    806       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1023   1220       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1345   1550       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4022   4057       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4945 AA;  554720 MW;  F62222BADEC2EDCF CRC64;
     MSDFGEGDEE FQFLRTGDEV VLQSIFTLRG EHVKICLAAE GFGTRLCRLE PIFNCKNVPP
     DVSVCGFVLA HCLSVRALQE MLTHTEHLAA ELAAGGGHRT LLYGQAVLFL HSYSSMYLSC
     LSSSQSATDK LAFDVGLQED KEGETCWWIV HPSSRQRSEG EKVRVGDDLI LVSMSSERYL
     HLSVGSGSDS SSSLSDSLSV SASFQPTLWS VAPIYSGGGV AQGYLKGGDT FRLHHSHSDA
     CLTIASADQG EEPQKVMHYE SGAVSSHARS LWRLEILHVV WSGSHTCWGQ PFRLCHMTTG
     RYMGLTEERG LHLVERDKAD VRMSSFCFRS SKEKLDPGTR TNADGMGSPE IKYGDSVCYV
     QHVDSGLWLT YRPVDAKSSR LRSTQRKAIL HSEGHMDDGL RLSRCQREES HTARLIRSAS
     FLFTNFIRKQ DSCSQHGNQV SVCSPGEMMK RSLQDLISYF YPTPETVEHE AKCHNMVVLK
     NRQNMFQEEG VIDLVLVCID HLHQHIGTSQ CAEAAQEDSE EEWESCLDGF YKLLAALLRG
     NRANCARFSA SIDWLISKLD WLEAATGVLE VLQCVLLESP EALNVVKENH IHSVISFLDK
     HGLNHKVLEV LCALCVCHGV AVRYNQNLIC DKLLPERDLL LQTRLVNRVT SMRPNIFLAF
     SEDSAQHRRW YYEVVVDHLD SFLTSEPTHL RVGWACTEGY RPRLSGGEGW GGNGVGDDLC
     SYGFDGLHLW AGGVGRSVSS PFSHSLKDGD VVSCCLDLSA PCISFRVNGL PVQGMLENFV
     AEGLLYPVVS FSAGVRIRFL FGGQHGEFRY LPPPGFTACS DALLPKVKLK VEPCQKYILN
     REEGKHDLIG PWIPTAPVVF IPAPVDISKV SLPPQLEDIQ EKLAENIHEL WAMDKIDLGW
     TYGPVRDEAK KNDPSLAEFS KLSEHERNQN LHVAQDTLRT LLAFGFCIGF NEGHSNDRVR
     NKRLAAKYEQ PGGYRPAPVD LSQVLLSSEH QEVVNLLAEN DHNVWARERI AQGWTYGTQQ
     DVKAKRSPYL VPYSFLDEKT RRLSRDSVRE VVGTLLAFGY SLDPHSLKQA TLANQCLFSA
     EKCRVFRPDK SHAVSRGKWY FEFEAVTAGK MRVGWARPSC SPSRELGSDD RAFVFDGFEA
     QWYHQGAEPL GRSWQRGDVV GCLVDMDEST MMITLNGELL FDARGSELAA KDFDISDGLL
     PVASLGVNQV GRLNLGRCAA SLQYFTVCGQ QEGYQPFAVN MARDPALWIS WQQPQFSSIR
     PDDHIQVGVT RASGSVGSLS SLRVSQRLFA HYNGSSQISF FRLSMHIECA SVLISPAGGV
     LPVASSSLSP GRREQEEVDP DFEVLRKSAL TFAGSRDELN HKDHNQEKTT RMKHRFLLKR
     NKPGLVSSNS SARLLEDVVF DKENCDHLIQ SSRYYYSARV LPGQEPFNVW VGWVTSNFHS
     HDATFDPDGV HTVTVTLGDD SGKVQESIKR RVCYMVCAGE ATGLAQSRRS SGLEIGCLID
     TATGLLTFTS NGVEMSTFFQ VEACTKLFPA VFVRPTTTCM FQFEFGCIKN AMPLSAGLLR
     SQRCNVTPHC PPRIQVQQLK PGSWTRLPSQ AVKVVVDQPD AYGGWTIQCS EALQVMNLQI
     PDENRCVDIL ELSELDDLLT FHLHTLRLYC SLCSLGNTRV SHAICSYLDT SQFLHAIQNP
     HLPGLLRSVF YQLLIQVHLS SHTTACLMMN HEYIIPMAAK AGDTTLYPSS FTGHNGGNGI
     TNSSHCTSLK PQMHFSSPSF VSNYALEGNY TAERNHGDSP EFPLDLLKNL TIQMLTEAVT
     ALCQEVRDPV GGTIELLLVP LIKLAYSLLV MGVLEDEDLG KVLRLLDSEV SFTNSQSSMD
     EEKEDEKDDE KEHSLHHHQK DSHPKIGLLQ IKLPEAVKLE LCHLLSYLCD CQMRQRVEAV
     AAFSDTFVCQ LQENQRFRYN EVMQALNMSA ALTARKTKEF RSPPREQINM LLSFRDDEVS
     CPCPVQIQEL LHNFHHLFKT HCGIESESDG EDEEAAESVR TQILSQVAKV IGIKKKPLEV
     DASKPVASSN HLSLETLKHL VSKTLVHWSQ EKMQDPELVR AVFSLLHCQY QGLGGQMAGP
     LSRTYTISHT SVDDTMALLS SLSQIRSLLC VRMGKEEEKL MIRKLGDIIN NKVFYQHPDL
     MRTLGMHETV MEVMVNVLGE GESKEIAFPK MVASCCRFLC YFCRISQHNQ GALFDHLSYL
     LENASVGLAS PSMRGATPLD VAAASVMDNN ELALALTESN LQKVIHYLAS CGLKSCPMLV
     AKGYPDIGWN PVEGERYLDF LRFAVFCNGE SVEENAYMVL RLLIRRPECF GPALQGDGGN
     GLLAAVREAI RISDDPSMDG PSGPHQSTRS IDVIQDNDDD LIHMGHAMVT FYSALIDLLG
     RCAPEMHLIE GGKGEALRVR AILRSLVPVH DLEGVISSSF CLPSVTKDGG VVEPDLSAVF
     CPDHKAAMVL FLDRVYGIQN QSFFLHLIEV GFLPDLQAAV SLDTVDLAST DMALALNRYL
     CASVLPLLSK CSALFCDLED HVLLVDSLIQ AIYSLSHALS LTKAQRDTIE DCLLALCSKL
     QPSLMQPLLR RLVFDVPHLP EHNKLALKLL TSHYEQRWKY YSMVGEPGDH SLASEEELHL
     SRKLFWSVFK DLNKKPYEPQ LFRLCVQCLA AVAKALPPDH TDAGCTSAME GKASADEQFD
     PQPIDTSNVS VPERLEFIVN KYAEHTHEKW SLDKFANGWV HGEQLCESSK VHPLLKPYRT
     LAEKEKEAYR CAIKETIKTM LAFGWSIERT KEADAHSVHT CARRVSQSGQ QLSFEGTSTF
     SPKPTDVSTI TLSWDQCAMA EQLAENYHST WAKRKKLELQ GRGGGGHSMV VPYDALTARE
     KTKFRERAQD VLKFLHLNGY TVWRDRRTVE MDFPAVANCF GSTLLMQFLS HTENTQEHML
     EMEVMQARGQ TSKGERTQLR QPVQVFHKVI LPLLEEYVRT HCLYFLSSMS LSGKRGHASN
     KEKEMIASLF CKLAALIRHR MSLFGNEASA VSNCLCTLAQ ALDARTLMNS ASESVRSSLD
     SFFESSAADL EMTVENLCVS VARLSQSRSQ HARGVARVLS YTSVVLLPTL TSLFQHLGLQ
     NYGGDLLVGT IQVSCYKILN SLYSLGTTSS IYMEGQRPAA GACLAALAAT FPVCFLEPDL
     NQNNPYSIYN TASALEKEEL GLPDHAGDMC PLLPSLEQAL GDVKQLAAAG AGARQSQYIH
     VTEVVLPMLC SYMSLWWSWG PEGQPNSPLC TTVTPQHASD LLGHVLRIIH NHVGTSQADW
     MKRMAVHCLS ITCHAHPELL KTHFLPLMEK LKKRAEGVLL EEERMKADAG DSSEAELEIQ
     QKFMVLVADL YAFYPLLIPF VDSNRARWLK ESTPEAEQLF IMVAEVFTFW AKSHNFKWEE
     QNYVVQNEIN SLLFLVKSNK LSKFFNFQLN HEKRKVKKKG DRYSTHTSLV VASLKRLLPV
     GLRNCLLSDR SLITLAKNGF TQKDTEDEIR QHIFSAFTLL QTQDHSFLND EVNDAERGGQ
     RGKTADVQKA VDRVLNMGRV LCYLDQVEHP QRNRKTARHK ILSKQRKRAV VACLRMAPLY
     NLPRHRAVNL FLQGYNKTWI STEDHSFEEK LVEDLALSGG VAENDTVDGI KAIDPLLQLI
     TLFSQTALME SSKLENGRLY QSYAAIMAKS CQRDDDGDGK EQELESFEEK ELEKQKLLFR
     QARLHRRGAS EMVLQIISAS RGLMGSVIAP TLKLGIALLS GGNAAVQQKM LVYLRERRDV
     GFFQSMAGLM LSCSVLDLSA FERQNKAEGL GMAMDESSGP LFSPADKVMP DKDVTCDLFR
     FLQLLCEGHN SEFQNYLRTQ AGNNTTVNIV ISTVDYLLRL QESVSDFFWY YSGKAAIDVH
     GQHNFSKAIE VSKQVFNTLT EYIQGPCAGN QESLAHSRLW DAVIGFLHVF AHMQMKLPQD
     SRQIDLLKEL LDLQKDMVVF LLSMLEGNIV NGTIGKQMVD MLVESSGNVQ MILRFFDMFL
     KLKDFTSSDA FQAYDPDFKG CVSRKDFQKA MEGCKRFSQA ETHFLMSCMG PDDREKVDYE
     AFVDGFHEPA QDIGFSIAVL LTNLSEHMPN DSRLRTFLEV AESVLTYFQP FLGRIEILGS
     GKRIERVYFG ISASSRTQWE KPQVKESKRQ FVFDVVNESG DKEKMEMFVN FCEDTIFEMQ
     LAAQLSGSGV EERHVEASPE EKGDTNGLDN KGIGVMCQWL VLTSVLSVKA LMKMSVKDVL
     VSAVVFLKFV LMAQFRCVLI VVRSIWYVLH RAFLSGELIE GAKRARISEM LGGILEPTLD
     EVMGGPRGTR LRKGSSSLTL QKELSGSRDM HVLSDIFGLT VKKEGSGYRL ISKDLTDSLT
     DLFTPACRGA TAGQVCLDHF CAILTLFSEP QTHIHQEEKT EEKGADGKQN KSDQNSEAIL
     KDPKWRAQRL NPKSKEAENQ PSALWEMVST HNKSMLNYFA RNFYNLRVLA LFVAFAINFI
     LLFYKVASSP AAQVEEKEMP SAYSAGDDAE EGTVCFVLEE RSGYMEPSLR FLAVAHTIIS
     FFCIFGYYCL KVPLVIFKRE KEVARKLEFD GLYVTKQPPE EDIKGQWDRL VVNTPSFPSN
     YWDKFVKRKV MDKYGEFYGC EKISDLLGLD QAALDCSSER KGRKRLRRST VWSHLFSSID
     VKYQVWKTGV VFTDNSFLYL AWYMAMSVLG HYNNFFFAAH LLDVAMGFKT LRTILSSVTH
     NGKQLVLTVG LLAVVVYLYT VLAFNFFRKF YNKSEDKDAR DMKCNDMLTC YMFHMYVGVR
     AGGGIGDEIE DPAGDEFEVE RIVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVKE
     DMETKCFICG IGSEYFDKVP HGFETHTLQE HNLANYLFFL MYLINKDETE YTGQESYVWK
     MYQERSWEFF PVGDCFRKQY EGQLG
//
DBGET integrated database retrieval system