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Database: UniProt
Entry: H3DR91_TETNG
LinkDB: H3DR91_TETNG
Original site: H3DR91_TETNG 
ID   H3DR91_TETNG            Unreviewed;      1717 AA.
AC   H3DR91;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-JUL-2017, entry version 37.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A {ECO:0000313|Ensembl:ENSTNIP00000023040};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000023040, ECO:0000313|Proteomes:UP000007303};
RN   [1] {ECO:0000313|Ensembl:ENSTNIP00000023040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|Ensembl:ENSTNIP00000023040}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTNIP00000023040}.
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DR   Ensembl; ENSTNIT00000023282; ENSTNIP00000023040; ENSTNIG00000015105.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     49     69       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    143    161       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    182    209       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    519    537       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    549    567       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    629    657       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    716    742       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    965    983       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1004   1023       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1035   1055       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1081   1107       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1204   1230       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1289   1307       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1319   1341       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1353   1372       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1416   1441       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1462   1481       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1509   1532       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        8    216       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      290    467       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      519    746       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      756    958       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      963   1238       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1288   1542       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      206    244       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1717 AA;  195206 MW;  B7A12B1AE600F01D CRC64;
     YITEFVDLGN VSALRTFRVL RALKTISVIP GLKTIVGALI QSVKKLSDVM ILTVFCLSVF
     ALIGLQLFMG NLRQKCVIWP INITDSQLSN KSQPFDWDEY ITNDTNFYFL PGQLDALLCG
     NSSDSGRCPE GYTCMKAGRN PNYGYTSFDS FGWAFLALFR LMTQDFWENL YMLTLRAAGK
     TYMIFFVLVI FVGSFYLVNL ILAVVAMAYE EQNQATMEEA QQKEEEFKAM LEQLKKQQED
     AQAAAMATSA GTVSEDAVED DGGGHLSCSS SEMSKLSSKS AKERRNRKKK WRQKEQEKEK
     GDSEKFVKSE SDDGSKRSRF RFPDNRLGRK SSIMNQSLLS IPGSPFLSRH NSKSSIFSFK
     GRSKDVGSEN EFADDEHSTV EECEERRGSL FSPYRRSSYS GFHGKRNSTV DCNGVVSLIG
     PGPGGRLLPE PTTEVEVKKK LSGSLMVSVD QLNTSFGRKE RANSVMSVIT NTLVEELEES
     QRKCPPCWYK FANTFLIWEC SPKWIKIKEI VNLIVMDPFV DLAITICIVL NTLFMAMEHY
     PMTPDFEHML SVGNLVFTGI FAGEMLFKLV AMDPYYYFQE AWNCFDGFIV TLSLVELALA
     DVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ
     LFGKNYKDCV CKIAQDCELP RWHMNDFFHS FLIVFRVLCG EWIETMWDCM EVAGQAMCLI
     VFMMVMVIGN LVVLNLFLAL LLSSFSADNL AATDDDGEPN NLQISVMRFK KGIAWTKSKV
     RILMASLLKK PPMEDEQKPL DDMYDKKLNF IANHTGVDIN RDLDYAKNGN GTTSGIGSSV
     GKYMIDEDHM SFIHNPNLTV CVPIAVGESD FENLNTEDFS SESDIENSKE LDDTSSSEGS
     TIDIKPDVEE VVVVETVEEY MEPEPCWTDA CVAKYKCCDV DITMGWGKSW WFLRKTCYVI
     VEHNWFETLI IFMILLSSGA LAFEDVYIEQ RKTIRIILEY ADRVFTYIFI LEMLLKWVAY
     GFVKYFTNAW CWLDFFIVDV SIVSLVANAL GYSDLGPIKS LRTLRALRPL RALSRFEGMR
     VVVNALVGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKYY YCFNETSEEM FSVDVVNNKT
     QCEALIKDNF TEVRWKNVKI NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SREVEDQPDY
     EVNIYMYIYF VVFIIFGSFF TLNLFIGVII DNFNQQKKKF GGQDIFMTEE QKKYYNAMKK
     LGSKKPQKPI PRPQNKIQGM VFDFVTQQVF DISIMILICL NMVTMMVETD DQSDETETVL
     YWVNFIFIVV FTTEFLLKLF ALRHYYFTNG WNIFDVVVVI LSIVGMFLAD IIEKYFVSPT
     LFRVIRLARI GRILRLIKGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI FSIFGMSNFG
     YVKHGAGIDD MYNFETFGNS MIILFMITTS GGWDGLLLPI LNYPPDCDPN SENPGTSVKG
     NCGNPSVGIF FFVMYIIISF LIVVNMYIAI ILENFSVATE ESADPLSEDD FETFYEIWEK
     FDPSASQFIT FAKLSDFADA LEHPLRVPKP NTIELIAMDM PMVSGDRIHC LDILFAFTKR
     VLGDSGELDM LRQQMEERFV AANPSKVSYE PITTTLRRKQ EDVSARIIQN AYRAHLIRRG
     IIFKRHTFTN NKLENGGTNQ EKKESTPSTP HSLRMTA
//
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