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Database: UniProt
Entry: H3EYW8_PRIPA
LinkDB: H3EYW8_PRIPA
Original site: H3EYW8_PRIPA 
ID   H3EYW8_PRIPA            Unreviewed;       662 AA.
AC   H3EYW8;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=WBGene00104587 {ECO:0000313|EnsemblMetazoa:PPA15033};
OS   Pristionchus pacificus (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Diplogasterida;
OC   Neodiplogasteridae; Pristionchus.
OX   NCBI_TaxID=54126 {ECO:0000313|EnsemblMetazoa:PPA15033};
RN   [1] {ECO:0000313|EnsemblMetazoa:PPA15033}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA15033};
RX   PubMed=18806794; DOI=10.1038/ng.227;
RA   Dieterich C., Clifton S.W., Schuster L.N., Chinwalla A.,
RA   Delehaunty K., Dinkelacker I., Fulton L., Fulton R., Godfrey J.,
RA   Minx P., Mitreva M., Roeseler W., Tian H., Witte H., Yang S.P.,
RA   Wilson R.K., Sommer R.J.;
RT   "The Pristionchus pacificus genome provides a unique perspective on
RT   nematode lifestyle and parasitism.";
RL   Nat. Genet. 40:1193-1198(2008).
RN   [2] {ECO:0000313|EnsemblMetazoa:PPA15033}
RP   IDENTIFICATION.
RC   STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA15033};
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   STRING; 54126.PPA15033; -.
DR   EnsemblMetazoa; PPA15033; PPA15033; PPA15033.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; H3EYW8; -.
DR   OMA; MILCERR; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000005239; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005239};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005239};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    150    174       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    195    213       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    287    306       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    327    347       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    359    377       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    420    439       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    459    481       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    598    625       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   662 AA;  74784 MW;  58F0CF9499920E00 CRC64;
     MSIGVMTRIE DLKTVLGQTQ DHRHRVLVAA AKNVRMWLTK VRKIKSIYHT LNLFNIDVTQ
     KCLIAECWCP VDALDRIRMA LKRGTYNKLE EESGSTVPSI LNRMDTTEAP PTYNKSNKYT
     VGFQNIVDAY GIATYREINP AIYTMISFPF LFAVMFGDMG HGTIMLLAAL FLILREKQLE
     AARIRDEIFQ MFFGGRYVIF LMGAFSIYTG FLYNDIFSKS LNIFGSAWAN SLLPNETQPF
     FDKGLLEVPL MLVPEKAYVT SPYPIGVDPV WNLAEANKLS FLNSMKMKSS VILGIGQMTF
     GLILSYHNYK YFHSDLDVKF MFIPQMLFMA CIFIYLCLQI IVKWLAYSAT AGVVFGYEYP
     GSNCAPSLLI GLINMFMMKS RDAGFVGADG KVSWGCSNNL WYPGQFYTFP LMAPFHFQSF
     FETVFVLIAL ACIPVMLFAK PYFMWKAEKE RQAGNGHMQL GTAETVLVIV AVVQIPIMLF
     VKPFFVWRRD KAAAATRESV RADMNGGDSE AEVVHHEPKT NGGGGHGHGD GPLDMADVMV
     YQAIHTIEFA LGCISHTASY LRLWALSLAH AQLSDVLWTM VFRAAFRSDG YIGAISTYLL
     FFAFFFLSVF ILVLMEGLSA FLHALRLHWV EFQSKFYGGH GYVFAPFSFE KILEAEREAE
     EA
//
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