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Database: UniProt
Entry: H3FG60_PRIPA
LinkDB: H3FG60_PRIPA
Original site: H3FG60_PRIPA 
ID   H3FG60_PRIPA            Unreviewed;       304 AA.
AC   H3FG60;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   07-JUN-2017, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=WBGene00110806 {ECO:0000313|EnsemblMetazoa:PPA21252};
OS   Pristionchus pacificus (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Diplogasterida;
OC   Neodiplogasteridae; Pristionchus.
OX   NCBI_TaxID=54126 {ECO:0000313|EnsemblMetazoa:PPA21252};
RN   [1] {ECO:0000313|EnsemblMetazoa:PPA21252}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA21252};
RX   PubMed=18806794; DOI=10.1038/ng.227;
RA   Dieterich C., Clifton S.W., Schuster L.N., Chinwalla A.,
RA   Delehaunty K., Dinkelacker I., Fulton L., Fulton R., Godfrey J.,
RA   Minx P., Mitreva M., Roeseler W., Tian H., Witte H., Yang S.P.,
RA   Wilson R.K., Sommer R.J.;
RT   "The Pristionchus pacificus genome provides a unique perspective on
RT   nematode lifestyle and parasitism.";
RL   Nat. Genet. 40:1193-1198(2008).
RN   [2] {ECO:0000313|EnsemblMetazoa:PPA21252}
RP   IDENTIFICATION.
RC   STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA21252};
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   STRING; 54126.PPA21252; -.
DR   EnsemblMetazoa; PPA21252; PPA21252; PPA21252.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; H3FG60; -.
DR   OMA; RNTHEQE; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000005239; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005239};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005239};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM     20     40       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM     52     76       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    137    158       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    205    223       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    243    270       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   304 AA;  33910 MW;  07ECA6C71AA1390B CRC64;
     MLDPVWDLAK NSLAFLNSMK MKMAIILGIM QMTVGLFLSL GNHLSKRAHI DVYFMCIPQL
     LFLASIFGYL CLQIVAKWVA FPAGSTWVFG RYYPGSSCAP SLLIGLINID TKPDDFIADF
     NCATAYWFPG ESIVEKFLLG IAVLSIPVML LGKPLYLWSR RPSSGHVNLD HAATHEEASL
     SEVFLFQAIH TIEFVLGCIS HTASYLRLWA LSLAHAVLSD VMWTKVLGLA TGVEGWLGAP
     AQFVIALFFG FLTVSILIVM EGLSAFLHAL RLHWVEFQSK FFSGNGVKFE PFSFEEKIRK
     MEDL
//
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