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Database: UniProt
Entry: H3FNX0_PRIPA
LinkDB: H3FNX0_PRIPA
Original site: H3FNX0_PRIPA 
ID   H3FNX0_PRIPA            Unreviewed;       890 AA.
AC   H3FNX0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   07-JUN-2017, entry version 25.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=WBGene00113536 {ECO:0000313|EnsemblMetazoa:PPA23982};
OS   Pristionchus pacificus (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Diplogasterida;
OC   Neodiplogasteridae; Pristionchus.
OX   NCBI_TaxID=54126 {ECO:0000313|EnsemblMetazoa:PPA23982};
RN   [1] {ECO:0000313|EnsemblMetazoa:PPA23982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA23982};
RX   PubMed=18806794; DOI=10.1038/ng.227;
RA   Dieterich C., Clifton S.W., Schuster L.N., Chinwalla A.,
RA   Delehaunty K., Dinkelacker I., Fulton L., Fulton R., Godfrey J.,
RA   Minx P., Mitreva M., Roeseler W., Tian H., Witte H., Yang S.P.,
RA   Wilson R.K., Sommer R.J.;
RT   "The Pristionchus pacificus genome provides a unique perspective on
RT   nematode lifestyle and parasitism.";
RL   Nat. Genet. 40:1193-1198(2008).
RN   [2] {ECO:0000313|EnsemblMetazoa:PPA23982}
RP   IDENTIFICATION.
RC   STRAIN=PS312 {ECO:0000313|EnsemblMetazoa:PPA23982};
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   STRING; 54126.PPA23982; -.
DR   EnsemblMetazoa; PPA23982; PPA23982; PPA23982.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; H3FNX0; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000005239; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0002119; P:nematode larval development; IEA:EnsemblMetazoa.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005239};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005239};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    426    451       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    585    606       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    618    641       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    653    672       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    722    741       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    827    854       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   890 AA;  102140 MW;  9667592D4F885CF4 CRC64;
     MAPKKFKEPS IFRSADMSLC QLFLQTDAAY QCVTELGEIG MVQFRDLNEE MNTYQRKFVN
     EVRRCDEMDR KLRFIEEEIV KDNVFITETT DPIRAPQPKD MNDLEARNIH PHEFVVTQSA
     TFEKIEEELL EINKNTKGLK DSHVQLWEMN QVIEKVKMML DAGHNRHHAS SVIQEAAHHP
     GLFDDEGKER GGTELKLVTG VIRRDRVRAF EQFLWRMCKG KVFMRTHDCD GEHDLFDGLE
     EKSVFILFFS GDQLAQRVNK ICLGFHARLY DCPEEPHLRL SMHKQIDERL ADLNNVIEKT
     LEHRKRVITA ASNSVYAWKI KVLKIKMVFH TLNMFSIDVT QKCLIAECWI PTNDLDDVRV
     ALRQGTIAAG SLVHPVLNEM EHHETPPTHF TLNKFTQGYQ NIVNAYGMAD YKELNPAPWC
     IISFPFLFGV MFGDVGHALI MFSFALMFII FEKKLEAMKI KDEIFNTFYS GRYIVLLMSM
     FSFYTGFIYN DIYSKSINII GSSWATGANN NSCWEWQGLK DSTTGLDYRD WEKTAAKNNQ
     TFEIMLDPIY CYDKETGPYI FGLDPVWNLA SNKLTFTNTM KMKSAVILGI MQMTFGLFVS
     LGNHIYNGSL VDVFFMFIPQ MLFLGCIFIY LCVQILVKWI FFPVDAAWVF GRFYPGSNCA
     PNLLIGLINM FMMTPRTDGF GEFKNTSAPY NIGDDVNLLD FDNDPNCGLA FWYPGESIAE
     KVLLVVAVVS IPLMLLVKPF YIKWRHGRGL SIGHSHSEDG EFSFGDVMVY QAIHTIEFAL
     GCISHTASYL RLWALSLAHA QLSEVLWTML LDMALKMKGW PGAPAQFIIF WIFGVLAVAI
     LVLMEGLSAF LHALRLHWVE FQSKFYGGNG IAFEPMSFYK QIRISEGLDV
//
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