ID   H3GC20_PHYRM            Unreviewed;       968 AA.
AC   H3GC20;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=Calcineurin-like phosphoesterase domain-containing protein {ECO:0000259|Pfam:PF00149};
OS   Phytophthora ramorum (Sudden oak death agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra72908, ECO:0000313|Proteomes:UP000005238};
RN   [1] {ECO:0000313|Proteomes:UP000005238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX   PubMed=16946064; DOI=10.1126/science.1128796;
RA   Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA   Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA   Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA   Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA   Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA   McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA   Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA   Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA   Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA   Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT   "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT   of pathogenesis.";
RL   Science 313:1261-1266(2006).
RN   [2] {ECO:0000313|EnsemblProtists:Phyra72908}
RP   IDENTIFICATION.
RC   STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra72908};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; DS565998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3GC20; -.
DR   EnsemblProtists; Phyra72908; Phyra72908; Phyra72908.
DR   VEuPathDB; FungiDB:PSURA_72908; -.
DR   eggNOG; ENOG502QSAS; Eukaryota.
DR   HOGENOM; CLU_008143_0_0_1; -.
DR   InParanoid; H3GC20; -.
DR   OMA; MRHLICD; -.
DR   Proteomes; UP000005238; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR34211; CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN; 1.
DR   PANTHER; PTHR34211:SF3; CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        45..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        681..700
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        707..728
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        819..841
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          368..559
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
SQ   SEQUENCE   968 AA;  109954 MW;  1E11C281415A7138 CRC64;
     MEVETTQAED QLVWFTLYLV IYLAFYFFTS PFVGNRELLN SWTPYVYVSM ALYAWLFSAA
     ALHTPVHALG LLDSTIKQPI SLLFPFFSAS FVFLIALEVL MVLFLSRITR RLGLSWTVAH
     VSLARSFMNV LRNSAAISVA CVALIVHCDA TYDCAASPDE PRTYNSHACA QIFSFVQSED
     EDTMVPGSYG GAVMIWCMGM LLAITNFFLE RMSGIRMIAS FGWFSNHIED VESGELAEEN
     GQERLPPEQN LPMVPWYSML LFDTVFELLI SLKVFLGRFD MRTMQRALHP NDEDYCFDHL
     AEKEEVWLDF MADCGDGFNS SYQIARLLAQ PQLEVDCEVN DEKLSDEDAS GDDETKTKKT
     KTIKRVFPRG DALVIGGDLA YPHPDSKTYE TRLFRCFEYA MKPPPSYHPS AISTQKKPPT
     GCSSLREYEG PSVFAIPGNH DWFDGLNTFT RYICQRDWLG GWLLPQKTSY FSLKLPHGWW
     LFGVDLALEN DVDTEQFGFF ERVVQSQMGP DDAVIVLTHE PRWLLDVYED RSNVDTKLSY
     LIENVLKGRV AVRLAGDVHN YSRHSLVEET HVLKRPASMQ FDTPRPKISI ADLPRRHSFS
     SPVHKHFPHM NWHEVSTNDG RIATDANLPS DAPAERERSA EHLIISGGGG SIYAAATWWE
     AAAQFYLELV QLLCDMVTTS YVSLLCSIGM LVGMICFADC TTLPKRCAMG LAVSCFHFVA
     AFTILLVYEC LLEVASVRGS LGSEGEHSLY LFFSSTLPDF SSIRKYDIFG LASLYGDFMQ
     LCMTIFDVPE VIALHRNKIC ASGFESLGRM ELWTYYASVF PYFWVLATPV VSFVFGTYLY
     LSLNIFGCHY NEAFSSLRIA SYKNFLRLHF DKEGRLEVFA FGVDKMPRRW CRDPKWSGGI
     GPRAALERKL PSFKWTRPSY WKPLVTKVDN LLRLDFENPS LDGKFNTTDR SNVHLIDRVL
     VRKPAASH
//