ID H3GIG8_PHYRM Unreviewed; 1036 AA.
AC H3GIG8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra75858, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra75858}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra75858};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; DS566011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GIG8; -.
DR STRING; 164328.H3GIG8; -.
DR EnsemblProtists; Phyra75858; Phyra75858; Phyra75858.
DR VEuPathDB; FungiDB:PSURA_75858; -.
DR eggNOG; KOG2066; Eukaryota.
DR HOGENOM; CLU_001285_2_2_1; -.
DR InParanoid; H3GIG8; -.
DR OMA; PQLVWQD; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00299; CLH; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00320; WD40; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT REPEAT 74..115
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 930..991
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 116225 MW; 1851989D63820BFB CRC64;
MASSAPESDS QETKEDTLPQ EPLLKYERVG GHFHAVFKDD SLSCIALHVN FVCAGTYGGN
VLLLELDGRF IRRLHQHYKK VNQVCIDETG QFIASCSDDG TVAVYTLFPG ASTTSAAADI
SGHKHASNQG RDVARQISVS STGGEVNIYN YFSAVYAVQL EDRYAMKREK SFACGGVGGQ
LIINRKGWII DKESTVHEGE GPVQVIRWKD GLVAWANDWG VKVYDSNNDQ RVTYIERPPN
CPPMELCRCH LEWQGNDVLL VAWAHTLRVV TFKKGHSGQP ASPTSAAALD AVEHSNGAIT
AEVVALLTFD FFVAGISPWG GGSVVSVLAF RPPGSGSSST GPPTSQGKST KVEGEGESGE
MPYPEVHVVR LDGKQVSADL LNLKGYQRLR ASDYMMPTLR YAHAHQSELE STDPSSIYDA
GYGQLAYVCT PKDVVICRLR DADDRVQWAL ARKQYARALD VALHDPRALR RVVLTDVMET
YLGDLLRQKK FQKTAEEIHR LFIGGGEDYA NLWEKYVYVF AQRGQLSAIA CYMPTASPRL
PKVQYEMVLK HFLDSDPGQL LELIRKWPKP RRQDTLAAKQ RSEGDASAVA PEYTETTHVF
EPLYDAQAWI NQLETVVRRR RIAEADAERL SVETMYLMEA LAELYTATEQ YDHALRIYLS
QGEFCSNKDF AFKLITEHQL WSLVANKVAN LMRIDKAIAV RMLVNQTEQL KISDIVTQLE
GEPELLHTYL HELVLHRLGE YNSEIYSALH EKQVALYAEF APDFLLKFLQ TSNFVPLEKA
YKYCSEHSPP LWDTMIYILG RMGQHKKALD LILTQRGDIN QAIQFVQDHD EGLWDYLIDL
SLTSKDNVEE LLKFASQHKI DPIKLIRKIP DDMEIVNLKQ KLIAIIANYR VQQNLCVGSR
KVFDNDRVEL LHRQVTAHKR GRRVAAKKAC AICNELLRAP STGMETVHAC VFECGHCYHL
PCLEEKMRMW KSAEAVESGD LNRALGCFVC DHSTRAYARS GDFSQQIASL TAPPARGVTE
DQLQRAKDNL LASVAE
//
