ID H3GJA5_PHYRM Unreviewed; 584 AA.
AC H3GJA5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=RNA methyltransferase {ECO:0000256|RuleBase:RU367087};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU367087};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra76235, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra76235}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra76235};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361, ECO:0000256|RuleBase:RU367087}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS566013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GJA5; -.
DR STRING; 164328.H3GJA5; -.
DR EnsemblProtists; Phyra76235; Phyra76235; Phyra76235.
DR VEuPathDB; FungiDB:PSURA_76235; -.
DR eggNOG; KOG2899; Eukaryota.
DR HOGENOM; CLU_467344_0_0_1; -.
DR InParanoid; H3GJA5; -.
DR OMA; QFWAVAS; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008171; F:O-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:2000632; P:negative regulation of pre-miRNA processing; IBA:GO_Central.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR039772; Bin3-like.
DR InterPro; IPR010675; Bin3_C.
DR InterPro; IPR024160; BIN3_SAM-bd_dom.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12315; BICOID-INTERACTING PROTEIN RELATED; 1.
DR PANTHER; PTHR12315:SF1; RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE; 1.
DR Pfam; PF06859; Bin3; 1.
DR Pfam; PF00035; dsrm; 1.
DR SMART; SM00358; DSRM; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51515; BIN3_SAM; 1.
DR PROSITE; PS50137; DS_RBD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU367087};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00848};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367087};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 368..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..369
FT /note="Bin3-type SAM"
FT /evidence="ECO:0000259|PROSITE:PS51515"
FT DOMAIN 93..161
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
SQ SEQUENCE 584 AA; 66072 MW; 5712949DBE306BB7 CRC64;
MASNDAEGHV LGNFHAYYSF NPVHERLRFM DVQTANALRR ALLVRKSAEE TSTVVDIGCN
EGDLTIGLYD ALNGRARLAD AKQIDDVASF DLMNISTLNE RMQKDKKQVE YVIQDKGETS
HRRRYVVELL VDGKAMGHGE GVSKKVAKAK AAEVALQVLD GSDSQKTQEK ESKDEKVVPE
QLPLTEQELA TRKSLMVLGV DIDKVLIERA TKKSVQLTVD DQVQFRHVDV MTSKFNEDIA
PFLELAKRST AERKFDLVTC FSVTMWIHLN NGDEGLWTFL ETVSDMTEHL IIEPQTWKCY
RNAQKRLNRM HVEVPQSFRE IKVRTDVVEK IDAFLLSAGR FRFKAQLGKT NWSRNTQMEE
VQDYSDIIYA HAVLLAVVLV PTLVRVRIVY TFLWNLFTVI AIKMESRTAQ GLATVMGLSV
MLSWYMLRYF DRSVFDSVLL GWFGLLSKYR VFRGLANTGD FLLHFVCPLA LAAKYLEHVE
VWMALPVLGY VDARVELVRN RLTCSFSVLW VYFVAGGSLV ANHVYHFSPP RPVQFWAVAS
ASMLVGNLTV PLGCVFAQRS GLPDLLVRGV EELAAPLRQS SFAV
//
