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Database: UniProt
Entry: H3GUI9_PHYRM
LinkDB: H3GUI9_PHYRM
Original site: H3GUI9_PHYRM 
ID   H3GUI9_PHYRM            Unreviewed;       869 AA.
AC   H3GUI9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-MAR-2016, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Phytophthora ramorum (Sudden oak death agent).
OC   Eukaryota; Stramenopiles; Oomycetes; Peronosporales; Phytophthora.
OX   NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra80897};
RN   [1] {ECO:0000313|EnsemblProtists:Phyra80897}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra80897};
RX   PubMed=16946064; DOI=10.1126/science.1128796;
RA   Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H.Y., Aerts A.,
RA   Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA   Damasceno C.M.B., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA   Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J.,
RA   Huang W., Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H.,
RA   Lee M.-K., McDonald W.H., Medina M., Meijer H.J.G., Nordberg E.K.,
RA   Maclean D.J., Ospina-Giraldo M.D., Morris P.F., Phuntumart V.,
RA   Putnam N.H., Rash S., Rose J.K.C., Sakihama Y., Salamov A.A.,
RA   Savidor A., Scheuring C.F., Smith B.M., Sobral B.W.S., Terry A.,
RA   Torto-Alalibo T.A., Win J., Xu Z., Zhang H., Grigoriev I.V.,
RA   Rokhsar D.S., Boore J.L.;
RT   "Phytophthora genome sequences uncover evolutionary origins and
RT   mechanisms of pathogenesis.";
RL   Science 313:1261-1266(2006).
RN   [2] {ECO:0000313|EnsemblProtists:Phyra80897}
RP   IDENTIFICATION.
RC   STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra80897};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; DS566051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 164328.Phyra80897; -.
DR   EnsemblProtists; Phyra80897; Phyra80897; Phyra80897.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; H3GUI9; -.
DR   Proteomes; UP000005238; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005238};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    428    452       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    473    491       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    571    589       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    601    624       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    683    702       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    803    828       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       99    133       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   869 AA;  98848 MW;  E1FAD8AEB9B9854F CRC64;
     MKWLRSAEME YISLIVNEDA AHDCVQKLGD LGVLEFTDLN PELTPFQRRY VNYVKRCDEM
     ERKLRYFEVE LAKFSITPKP AGSIDQFLAG SADIRYGSQD TAARALDTLE RLLEDKEQEL
     LQLNSMHEKL TREYNERKEL QEIISRAGEF FEIEIPEVQA RRTSRTGSRS GGYSFVEASA
     GAGGEDSSTL RFRNVTGVVP ADERLKFERM IFRTTRGNCF TRFSPIEEPL ADPTNGQPVT
     KHAFVIFFQS TFIENKLRKI CDAFHARLYS LPPMDDRAAI AHLIQSNAGE LNQSSHILRR
     NRESCVLLCR DLAETLESWK WSVLQEKATY HALNMFRADV SGMLRAEGWV IKEALSSVRR
     AVTRAHTAAD DKSMPSLVDS VAKPWPVPPT YFETNKFTDA FQAFVETYGC PRYREVNPSV
     FTAVTFPFLF GVMYGDIGHG LCVLLFGLYL ILTERRLEHP GSMGEMTASI YGGRYMLFMM
     GAFAMYAGLI YNDFFSLPLN LFGSKFAYPD CLESHDREAK CVAEYIIDGK MTYVNATDVS
     AGDNVYAMGL DPVWKTSSNE LLFFNSFKMK ISVIFGIIQM TFGILLKGWN NIYFRDYSTF
     FFEFVPQIVF AVSLFCYMIV LIVMKWSINW TERMKHEVCP YNYAGEHTGC RPPSLVNTLI
     NIALAPGNVV DPLYEGQLET QQTLLMMAFV SVPAMLLIKP IYLKIQHDRT APPVSHHVDF
     DDEAEERLVT QHHGNSGGHG GHGEEFEFGE VVIHQGIETI EFVLGMVSNT ASYLRLWALS
     LAHSELATVF WEKTMLSTIN SDSFIAIFIG FGVFAATTFG VILAMDVLEC FLHALRLHWV
     EFQNKFYKAD GYKFHPFSFK QTIKDSQQV
//
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