ID H3GUL4_PHYRM Unreviewed; 1463 AA.
AC H3GUL4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra80928, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra80928}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra80928};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS566051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 164328.H3GUL4; -.
DR EnsemblProtists; Phyra80928; Phyra80928; Phyra80928.
DR VEuPathDB; FungiDB:PSURA_80928; -.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_001275_0_0_1; -.
DR InParanoid; H3GUL4; -.
DR OMA; HAGSWIL; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 832..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..936
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1051..1072
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1148..1172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1188..1223
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1376..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1463 AA; 164761 MW; 2F268603B5BDDCB7 CRC64;
MPPPDRGYTG FHSSQASFLT VFLITLRSGF GPSLDGAQQA SSYFSIIYFI GLIVFVSYMI
LSLFVGIVRG SYITVSIVRA AKLAEQEKRM DKYLKKPRLQ FPKGTEAFPD VMQVLDAKWQ
VYRARFKEWL LGSPLFTRSD GTFLSWCRLR QERIFFLLEP GSQVMDRISS IAESLAFEHI
MNLVVFFNSV LFALEYHGMS DSYAARLYMI ENFLMLVYGT EFVIIAAAAG GLIGYLQNPW
NRLDFVLLVI ACVEFLLLTC SVLLYSDSYA RGIFVLRLFR LVRPFRVVRQ NNKLLLVLDA
ILASVPAFLS SIAFHVLLNS VFAVVGMNLF GGNFPLTMQS HFNTFSDSML TLFKFSNGGS
VWPIFHASLQ ASSFGVALLY YLTYVVLCRF LALNFMLVVL LRNFAMKGDE RRKTLSELFQ
DRMFAMQRIH LFDMYTFVEE FSNLYQGDVM NVSLPGSAKK RAQRALSASE AFKARLFNVL
PTSDFLKLKG YYGTTRNQQD RKYIQLEGPA PAHGKHKNQA TVTPIDDSVS SAAAAAIVPV
SGLESPADTS GPDEWTGWTS TGGTTGYVRQ FFDGHWLMAD VSLFLFPPQS WVRLKARRLE
KETEKYIFAA IVIRTVMLTV QSPLYSSLIQ ELTTLSDVVY AIVLFFEFAL KVISRGFFFT
PKSYLSNTWN QINMVVLMAC SLLLLLPHST MISLFRLGRA FGPIRVFYRV RTFRVITEAL
KQSARPIFYC VVLSVFLFYS FATLGMQIFG GRFAYCSDPS VDTPEKCVGV FWNSATGILT
PRVWGNLSGL HFDNITGAMS SILFLISMKG WLPVVNIAMD FVDDMDANSE HQASAIASTY
FAGFFVAFLF FTRFYLLKVF AGILMNNFRC YNGTLLLTNL QLIWLRKKQA IVAMRPKYPL
PTSRFMQLAQ VYMQKRSFRG FISTVVILHT SLLAWYRSPI HRANTDGNVD VSAGVWWFHY
IFSLIYALDA VLRVAAVGWR DFLMKGFTWR TFNSCTAFIM LVGPLLSDSP VLLVLGMTRA
FDFKHLSLVL ERSRALRTLF RTLLASVQLT LKVTLLLGYV LFVFAIVGVQ VFSLTRWASG
LNGNLNLTTF PMAYAAFVKF AAGEDWYATY LASSVEPPQC VLSGRSSTSA SYASDCGSPV
ISGLFYNFFY VLVVLILQNL YAATMVDTYV LMSARTNDNE QLLGFQAEHL QRFQTIWSDF
DTDALGLVRR KHLLTLLTRL EPPLGLGTHK AMLDSLATED TTPEEWTALS NAVHQRRRET
FHDIEARIAE LAYRVRLGLG SYDGLNGSVS VSANPDLVCP PNMIRFTDLL LVLTMRVLPL
ESLTVQEKVD ELAMRGYSFR HRKAIIIQSA FRMFRVRRRT TSRIRKAKRS IEIKRQQSDV
AVNATSTAQP EEKTQPTEGE PPSQKTVTSL ALAIAPPTLA LPASICVPNA TSERLRAPAS
VAPILSEHLE LQPEASDARK CSI
//
