ID H3H555_PHYRM Unreviewed; 949 AA.
AC H3H555;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra85740, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra85740}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra85740};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; DS566288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3H555; -.
DR EnsemblProtists; Phyra85740; Phyra85740; Phyra85740.
DR VEuPathDB; FungiDB:PSURA_85740; -.
DR HOGENOM; CLU_000384_38_0_1; -.
DR InParanoid; H3H555; -.
DR OMA; DNICADI; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF36; RT_RNASEH_2 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT DOMAIN 1..152
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 544..705
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 857..919
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 914..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 949 AA; 106966 MW; B20EAB2F0FA86AA3 CRC64;
MTIDTRSVNE RTEPMPWPMP VLEVVIGELE GAKVFFVLDW FRGYWQLPLH PDSQEIYSFV
THRGIYTPTR VPMGATDAVA YCQGVVEEIF GDLLGTCILA WLDDILGYAE DEASLLEVLD
KVLERCEKFG LKLHAKKCQF FATEVKWCGR MISAQGVRHC PERIQGLVEM QAPQTAGDLQ
QFLCAVNWMR QSIPEFTRIT AVLYDALDRA AQIAGSRKKV KLARVRLEDV SWGADEMAGV
EAVRDALLNM VPLAHPSPTA DLCLYSDASN DYWGAVVTML DPEELKLPRA EQHHRPLAFL
SGRFVGAAQR WPTIEKEAFA IVEAVRRLEY LLLRPRGFHL FTDHRNLVYI FNPYATDGMM
ARYQADKLQR WALALMSFRY VIEHVPGEEN AWGDLLSRWG AGPPLEATRT AIRAARLAVV
ERVSPLEEAD FVWPSEQEIR AVQQAAGAAA HPGVQWNEER QLQMTSTGQV WIPPDSGELQ
QRLCVVAHAG ASGHRGAAAT LKSLSTCFFW PTMGPDVTTF VNECLHCMVA AGGRIPRPFG
ETLRATRPNE VLHFDFLTMI MSTSGVKYVL VLKDGMSGFV ELLACTHATS DHAYQGLIDW
FKRFGVVHQW VSDQGAHFRN QVVERLQRAL GAHHHFTTAY TPWANGTVEV VNREVLKSVK
ALLSERRMHV QDWPAVLPVV QAALNAMPAD RLDGRSPLTA FTALPADSQL RSILHPRSPT
QATLEWVDSE VRSHLTAVRE ALDNMHAEMV SASEKRRRAA RERHARRQGV RLHKFSEGDF
VLAATATGRS GHKLALVWRG PKRILKALND YTFEVQDIIE PFAVTIRHAS RLQLYRDAAR
GRVEELQEQA IYGEGGHLVE ALLDCRLSPD SHRWEVFVKW FGLDDIEASW EPADIIKQDV
PGLFQVFVDD QPEARSRRDM AAALAGPDRD DERPAQRAPR RRQPRQPRT
//
