ID H3HAM2_PHYRM Unreviewed; 612 AA.
AC H3HAM2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=protein-L-isoaspartate(D-aspartate) O-methyltransferase {ECO:0000256|ARBA:ARBA00011890};
DE EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra93247, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra93247}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra93247};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
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DR EMBL; DS565998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3HAM2; -.
DR STRING; 164328.H3HAM2; -.
DR EnsemblProtists; Phyra93247; Phyra93247; Phyra93247.
DR VEuPathDB; FungiDB:PSURA_93247; -.
DR eggNOG; KOG1543; Eukaryota.
DR eggNOG; KOG1661; Eukaryota.
DR HOGENOM; CLU_397667_0_0_1; -.
DR InParanoid; H3HAM2; -.
DR OMA; NIESHGA; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF0; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR Pfam; PF01135; PCMT; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT DOMAIN 143..385
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 66113 MW; B3923F414214A6C3 CRC64;
MAITDKSDLP LLQPRTSTLL SPSNGPETST SSLLQSSWEN FRADRFRLRS IGSVLGWIVL
GCFVNSAVLA PKQLADYTHD GVAMHAVQDQ LDLMAACAAA GTETGEGGVA TVQTNKGAGW
FLGGNDPEHV LTPLQEVRSF DDLPENWDWR DYNGTGISLT TSIMNQMVPL SALSDRIRIA
RFKKTGRLDT EVLLSPQVLL DCGMRSFGSC HGGDPRHAHK WIHENGIVDL TCNPYIASHP
SWMGGGDCAA TQCHTCNLKG ECFVLEDPVK YRISEYGTLN FTTSEEFQLQ AMNEIYHRGP
IVVSMYSLSP EYRQFKGGYI LRDSTKYPGT THVVSLVGWG TDAKTGVKYW VVRNSDGTNW
GDRGFFLAER GVNIYNIESH GAWAVPIVVL SGISEDLLVS TSIGHQIGGD SHAALVDSLV
RTNVVASGSR LEAALRRVDR GDFVAPAFRA SSDRYANRPL KIGSVATIST PQQHAQVLGL
LEKHLRSGMT AVDVGCGSGI LVAAMAHLVG PMGFVTGVDI VPELVEFSKQ NLQRSLGKED
AEKQTEILLS TGKRDLGLPS HGRYDCIHVG VAVETKAEAE SFLEYLKPGG GLLIPLGGAG
AEQKLVKTSA IS
//
