ID H3NCJ5_9LACT Unreviewed; 752 AA.
AC H3NCJ5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHR34871.1};
GN ORFNames=HMPREF9703_00276 {ECO:0000313|EMBL:EHR34871.1};
OS Dolosigranulum pigrum ATCC 51524.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Dolosigranulum.
OX NCBI_TaxID=883103 {ECO:0000313|EMBL:EHR34871.1, ECO:0000313|Proteomes:UP000003599};
RN [1] {ECO:0000313|EMBL:EHR34871.1, ECO:0000313|Proteomes:UP000003599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51524 {ECO:0000313|EMBL:EHR34871.1,
RC ECO:0000313|Proteomes:UP000003599};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Dolosigranulum pigrum ATCC 51524.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHR34871.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGEF01000002; EHR34871.1; -; Genomic_DNA.
DR RefSeq; WP_004634947.1; NZ_JH601103.1.
DR AlphaFoldDB; H3NCJ5; -.
DR STRING; 29394.BWX42_08970; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_9; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000003599; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000003599}.
FT DOMAIN 6..185
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 188..285
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 752 AA; 85300 MW; 6DA8FA5DFF1921C1 CRC64;
MTIQSVHILG AGQMGRDLAS WCISRGLETT LVKMTDVTEG LIDKKTEQSI QADIQQKLQE
TDRIHHLRFI SYPQFLEEAA TCEWVIESVI EDLTIKQDVW AEVAEAVAVE AILSTNTSSL
QVKEIATNLP EQVQERFSGV HFFTPLSQSK LVELIPLDQT TPQYINQLKQ LVDKVLAKRF
IVSRDVTGFV ANRMGFYANY EAMYRGEARH WPIPKVDALT GAKLARVKMG PYRLTDLTGI
DLSESALKAY RQNTFLAEYF PPRTQHHALL KAGYVGDKAG QGYYKKEQGE RLAFDFETRE
YRQASFPTFP FFEKFETGDW EHNLDIIFTE DSPEAHFMWE SLRNVMYFAA LNVGRAADDY
RTIDQALIWG YNWTLGPFQI WDKLGFHRVK ERIEVECGPL PDWIQTIQGG FYPEDRPLDS
DNSPQAIAEK ILWHHDHQTR LSQTKQNSLV LELRTANHAL NPAVLEDILA AVDELEQGHY
EGLVIIGEGE HFSVGFDFSG FEMIKQAPHP SQKAKEISNL GYEVVKRLKF ARKPIVAAVR
GHVLGGGAEI ALQSTRIVAA AQTYMGLPEV GVGLLPAGGG LAELADRIYQ QDDSRFEKKQ
KLLAMFNTVA YGQVSKHAQH ARELGFLRTE DIIVANERYL LQTALSMVQM LSQAGHISAT
NIRYQALGQD FKAVVSGLVK NWRIGGYVTD FEQELANRIA DVLAGGELPL GVEIDYEYLL
QLEQSHYLEL IEHDLTWERL HHMQVYKRPL RN
//