ID H3NUP0_9GAMM Unreviewed; 496 AA.
AC H3NUP0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:EHQ57507.1};
GN ORFNames=OMB55_00012400 {ECO:0000313|EMBL:EHQ57507.1};
OS gamma proteobacterium HIMB55.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae.
OX NCBI_TaxID=745014 {ECO:0000313|EMBL:EHQ57507.1, ECO:0000313|Proteomes:UP000003408};
RN [1] {ECO:0000313|EMBL:EHQ57507.1, ECO:0000313|Proteomes:UP000003408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HIMB55 {ECO:0000313|EMBL:EHQ57507.1,
RC ECO:0000313|Proteomes:UP000003408};
RX PubMed=22493201; DOI=10.1128/JB.00171-12;
RA Huggett M.J., Rappe M.S.;
RT "Genome Sequence of Strain HIMB55, a Novel Marine Gammaproteobacterium of
RT the OM60/NOR5 Clade.";
RL J. Bacteriol. 194:2393-2394(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHQ57507.1}.
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DR EMBL; AGIF02000001; EHQ57507.1; -; Genomic_DNA.
DR AlphaFoldDB; H3NUP0; -.
DR STRING; 745014.OMB55_00012400; -.
DR PATRIC; fig|745014.4.peg.1253; -.
DR eggNOG; COG0446; Bacteria.
DR OrthoDB; 6278312at2; -.
DR Proteomes; UP000003408; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000003408}.
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 79
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 328
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 337
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 341
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 496 AA; 56222 MW; 9FF9F79D5A44D1A1 CRC64;
MNQRTVEKVV IAGGGTAGWM AAAALSRLVG RKISVTLVES EEIGTVGVGE ATIPTILTIN
RLLQIPEPDF IKLTSGTFKL GIRFENWQKQ GEDYIHSFGD TGKGSWAAGF HHFWLRAKEM
GLAEDYGEYC TELKAAEAER FAITSQNKLN YAYHLDASKY GMYLRKLAES SGATRIEGKI
QRVETSSEDG FIEALHLEDG QRIEGDLFID CTGFRALLSE GALQTGFDDW SHWLPANRAW
AVQSELNEHP KPYTRAIAHK VGWQWRIPLQ HRAGNGLVYS NDFMDEETAR DLLLANVPDK
PLTDPRPIKF VTGQRKQYWN KNCIAIGLSS GFIEPLESTS IHFIQNGIMW LLLMFPDTCI
EPSTVNEYNR TMRSEAEHIR DFIVLHYTLN QRYGDPFWDH CRNMDLPDSL KHRMELFERS
ARVFKPQDDV FAENSWVQVM MGQGMYPEGY HNIAQAMSES QMTAFLKGIQ HEVAQTVAKL
PEHGAFVKTL VQHAKV
//
