ID H3SIG1_9BACL Unreviewed; 347 AA.
AC H3SIG1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=L-threonine 3-dehydrogenase {ECO:0000313|EMBL:EHQ61164.1};
DE EC=1.1.1.103 {ECO:0000313|EMBL:EHQ61164.1};
GN Name=tdh {ECO:0000313|EMBL:EHQ61164.1};
GN ORFNames=PDENDC454_16673 {ECO:0000313|EMBL:EHQ61164.1};
OS Paenibacillus dendritiformis C454.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1131935 {ECO:0000313|EMBL:EHQ61164.1, ECO:0000313|Proteomes:UP000003900};
RN [1] {ECO:0000313|EMBL:EHQ61164.1, ECO:0000313|Proteomes:UP000003900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C454 {ECO:0000313|EMBL:EHQ61164.1,
RC ECO:0000313|Proteomes:UP000003900};
RX PubMed=22461558; DOI=10.1128/JB.00158-12;
RA Sirota-Madi A., Olender T., Helman Y., Brainis I., Finkelshtein A.,
RA Roth D., Hagai E., Leshkowitz D., Brodsky L., Galatenko V., Nikolaev V.,
RA Gutnick D.L., Lancet D., Ben-Jacob E.;
RT "Genome Sequence of the Pattern-Forming Social Bacterium Paenibacillus
RT dendritiformis C454 Chiral Morphotype.";
RL J. Bacteriol. 194:2127-2128(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHQ61164.1}.
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DR EMBL; AHKH01000046; EHQ61164.1; -; Genomic_DNA.
DR RefSeq; WP_006677825.1; NZ_AHKH01000046.1.
DR AlphaFoldDB; H3SIG1; -.
DR STRING; 1131935.PDENDC454_16673; -.
DR PATRIC; fig|1131935.3.peg.3471; -.
DR OrthoDB; 9777057at2; -.
DR Proteomes; UP000003900; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008743; F:L-threonine 3-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006567; P:threonine catabolic process; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR004627; L-Threonine_3-DHase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR NCBIfam; TIGR00692; tdh; 1.
DR PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR43401:SF2; L-THREONINE 3-DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EHQ61164.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003900};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 16..344
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 347 AA; 36942 MW; 8BF38E88222AD9A2 CRC64;
MTATMIGLVK AERKPGAVLK EVPVPAYGPD EVLVRVKASS ICGTDVHIYK WDDWAARTVV
TPNVFGHEFA GIVEAVGDRV TNVKVGDHVS GEGHVVCGVC KSCRTGNAHV CPHTRSFGIT
LPGCFGEYAV LRASNVIQND PKLPFEIACL QDPLGNAVQT VLAGDIVGKS VAVVGVGPIG
LMAIAVAKAC GSGTIIAVDI NPYRLEMAKT MGADVIVNSK EVNSVQAIRE ATNGEGAEVV
LEMSGHPDAI RDALKAAAQA GRVSLLGIPS KEVAFDLAED VIFKGLQLVG ITGRRMYDTW
YQLKGLLERG RIDLTPIITH RLTLDRYEEA FDLMSSGNCG KIVFIHQ
//
