ID H3ZNQ7_THELN Unreviewed; 316 AA.
AC H3ZNQ7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Biotin synthase {ECO:0000313|EMBL:EHR78466.1};
GN ORFNames=OCC_12346 {ECO:0000313|EMBL:EHR78466.1};
OS Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=523849 {ECO:0000313|EMBL:EHR78466.1, ECO:0000313|Proteomes:UP000015502};
RN [1] {ECO:0000313|EMBL:EHR78466.1, ECO:0000313|Proteomes:UP000015502}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51850 / DSM 5473 / JCM 8560 / NS-C
RC {ECO:0000313|Proteomes:UP000015502};
RX PubMed=22493191; DOI=10.1128/JB.00123-12;
RA Gardner A.F., Kumar S., Perler F.B.;
RT "Genome sequence of the model hyperthermophilic archaeon Thermococcus
RT litoralis NS-C.";
RL J. Bacteriol. 194:2375-2376(2012).
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DR EMBL; CP006670; EHR78466.1; -; Genomic_DNA.
DR RefSeq; WP_004068415.1; NC_022084.1.
DR AlphaFoldDB; H3ZNQ7; -.
DR STRING; 523849.OCC_12346; -.
DR PaxDb; 523849-OCC_12346; -.
DR GeneID; 16549033; -.
DR KEGG; tlt:OCC_12346; -.
DR HOGENOM; CLU_054041_0_0_2; -.
DR OrthoDB; 15118at2157; -.
DR Proteomes; UP000015502; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0004076; F:biotin synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009102; P:biotin biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002684; Biotin_synth/BioAB.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR22976; BIOTIN SYNTHASE; 1.
DR PANTHER; PTHR22976:SF2; BIOTIN SYNTHASE, MITOCHONDRIAL; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01098; Uncharacterised_Radical_SAM_Su; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 21..248
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 316 AA; 36430 MW; BF94F390AA00DCE7 CRC64;
MKIRASYGTA VVLGLKKGKM FAKPTTAYFM TYYEGRCLNN CAFCVQARES RADVEKLSRI
TWPAFELDEV VEKLKSSKFA RICLQTIDYP NLREDVLKIL KAFYPLGLPV SLSITPVDKK
SLRDFQKLGV DYIGVGIDAA SERVYNKVKD SMYSWEDMWR FVEEVIDVFG KGKAFVHLIF
GLGESEEEFL QAVQRVYDSK AKVSIFAFTP IKGTILENKA PPDPNRYRLM QIGVYLIENK
IARVEEFKFE SGMLVDFGLS KEELLKVLDE SAFMTHGCPG CNRPYYNEKP SKEPYNFPVR
PEKRQFERLL NRLFNE
//
