ID H3ZPH0_THELN Unreviewed; 186 AA.
AC H3ZPH0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Pyruvate/ketoisovalerate oxidoreductases common subunit gamma {ECO:0000256|ARBA:ARBA00015298};
DE EC=1.2.7.7 {ECO:0000256|ARBA:ARBA00012813};
GN ORFNames=OCC_04103 {ECO:0000313|EMBL:EHR78205.1};
OS Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=523849 {ECO:0000313|EMBL:EHR78205.1, ECO:0000313|Proteomes:UP000015502};
RN [1] {ECO:0000313|EMBL:EHR78205.1, ECO:0000313|Proteomes:UP000015502}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51850 / DSM 5473 / JCM 8560 / NS-C
RC {ECO:0000313|Proteomes:UP000015502};
RX PubMed=22493191; DOI=10.1128/JB.00123-12;
RA Gardner A.F., Kumar S., Perler F.B.;
RT "Genome sequence of the model hyperthermophilic archaeon Thermococcus
RT litoralis NS-C.";
RL J. Bacteriol. 194:2375-2376(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-
CC [ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-
CC 2S]-[ferredoxin]; Xref=Rhea:RHEA:11712, Rhea:RHEA-COMP:10000,
CC Rhea:RHEA-COMP:10001, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57338; EC=1.2.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000257};
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DR EMBL; CP006670; EHR78205.1; -; Genomic_DNA.
DR RefSeq; WP_004068953.1; NC_022084.1.
DR AlphaFoldDB; H3ZPH0; -.
DR STRING; 523849.OCC_04103; -.
DR PaxDb; 523849-OCC_04103; -.
DR GeneID; 16550171; -.
DR KEGG; tlt:OCC_04103; -.
DR HOGENOM; CLU_087284_0_0_2; -.
DR OrthoDB; 18183at2157; -.
DR Proteomes; UP000015502; Chromosome.
DR GO; GO:0043807; F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity; IEA:UniProtKB-EC.
DR GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR InterPro; IPR011894; PorC_KorC.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR NCBIfam; TIGR02175; PorC_KorC; 1.
DR PANTHER; PTHR42730; 2-OXOGLUTARATE SYNTHASE SUBUNIT KORC; 1.
DR PANTHER; PTHR42730:SF1; 2-OXOGLUTARATE SYNTHASE SUBUNIT KORC; 1.
DR Pfam; PF01558; POR; 1.
DR SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EHR78205.1}.
FT DOMAIN 11..176
FT /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01558"
SQ SEQUENCE 186 AA; 19957 MW; 8317F866CA4D2C03 CRC64;
MRKEVLIGGF GGQGVILASV ILGRAAAVYE GLYAVQTQAY GPESRGGASR AEVVISDEPI
DYPKALAPDY AVLLSQQAYE KYLPLVKKGG IVIVEKDLVP NRNEELEKNF KVFAIPLTEI
AEETTGLSLT MNILTLGLLV KLAGIVSEDS IEKAVLDSVP KGTENINLRA LKKGFELGEK
ALKGEI
//
