ID   H5SGC4_9ZZZZ            Unreviewed;       273 AA.
AC   H5SGC4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-FEB-2023, entry version 24.
DE   SubName: Full=IclR-family transcriptional regulator {ECO:0000313|EMBL:BAL55210.1};
GN   ORFNames=HGMM_F24F10C28 {ECO:0000313|EMBL:BAL55210.1};
OS   uncultured prokaryote.
OC   unclassified sequences; environmental samples.
OX   NCBI_TaxID=198431 {ECO:0000313|EMBL:BAL55210.1};
RN   [1] {ECO:0000313|EMBL:BAL55210.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16309394; DOI=10.1111/j.1462-2920.2005.00881.x;
RA   Nunoura T., Hirayama H., Takami H., Oida H., Nishi S., Shimamura S.,
RA   Suzuki Y., Inagaki F., Takai K., Nealson K.H., Horikoshi K.;
RT   "Genetic and functional properties of uncultivated thermophilic
RT   crenarchaeotes from a subsurface gold mine as revealed by analysis of
RT   genome fragments.";
RL   Environ. Microbiol. 7:1967-1984(2005).
RN   [2] {ECO:0000313|EMBL:BAL55210.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Takami H., Noguchi H., Takaki Y., Uchiyama I., Toyoda A., Nishi S.,
RA   Chee G.-J., Arai W., Nunoura T., Itoh T., Hattori M., Takai K.;
RT   "A Deeply Branching Thermophilic Bacterium with an Ancient Acetyl-CoA
RT   Pathway Dominates a Subsurface Ecosystem.";
RL   PLoS ONE 7:e30559-e30559(2012).
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DR   EMBL; AP011712; BAL55210.1; -; Genomic_DNA.
DR   AlphaFoldDB; H5SGC4; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR   PANTHER; PTHR30136:SF35; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   4: Predicted;
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          5..67
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51077"
FT   DOMAIN          68..251
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000259|PROSITE:PS51078"
SQ   SEQUENCE   273 AA;  29310 MW;  6A7B0DC37D3A1EFD CRC64;
     MAAHSPAVSR AVAALDALAR ASDGLTLSEL ARETGEPKST LHAILATLVE AGLLVRDGAT
     KRYRLGPHLL ALAGAYARQS DLLRAFGEVA RPLARELGET IQLAILQGRD VLYVGKQEGT
     QWVRLASEVG TRLPAHATSL GKCLLAWLPP EELERLLAAG PLVALTPRTI TDPDILRAEL
     AQVRERGYAI DRGETLPDVW CFGAPVRDAQ GAVVAALSIS VPVTRIAPER IDELIAAARW
     AATELSLRLG YCDMVTAEGE EVIEDVQRRR VAP
//