ID H5TYH5_9ACTN Unreviewed; 558 AA.
AC H5TYH5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=GOSPT_045_01720 {ECO:0000313|EMBL:GAB38533.1};
OS Gordonia sputi NBRC 100414.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1089453 {ECO:0000313|EMBL:GAB38533.1, ECO:0000313|Proteomes:UP000005845};
RN [1] {ECO:0000313|EMBL:GAB38533.1, ECO:0000313|Proteomes:UP000005845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 100414 {ECO:0000313|EMBL:GAB38533.1,
RC ECO:0000313|Proteomes:UP000005845};
RA Yoshida I., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Gordonia sputi NBRC 100414.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB38533.1}.
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DR EMBL; BAFC01000045; GAB38533.1; -; Genomic_DNA.
DR RefSeq; WP_005204413.1; NZ_BAFC01000045.1.
DR AlphaFoldDB; H5TYH5; -.
DR eggNOG; COG1061; Bacteria.
DR Proteomes; UP000005845; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:GAB38533.1};
KW Helicase {ECO:0000313|EMBL:GAB38533.1};
KW Hydrolase {ECO:0000313|EMBL:GAB38533.1};
KW Nucleotide-binding {ECO:0000313|EMBL:GAB38533.1}.
FT DOMAIN 193..347
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 401..547
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 558 AA; 61587 MW; F5ACFE97751B3932 CRC64;
MARVTDGPLI VQSDKTLLLE VDHPDAAAAR GAIAPFAELE RAPEHVHTYR VTPLALWNAR
AAGHDAEQVV DALVSFSRYA VPQPLLMDIV DTMGRFGRLQ LVKSPVHGLT LVSFDRAVLE
EILRNKKVAP MLGARIDDDT VVVHPSERGR LKQVLLKVGW PAEDLAGYVD GEAHPIALEQ
DEWHLRDYQE MAADSFWAGG SGVVVLPCGA GKTMVGAAAM AKAQATTLIL VTNTVAGRQW
KRELIARTSL TEEEIGEYSG ERKEIRPVTI ATYQVMTRKS KGEYKNLDLF DSRDWGLIVY
DEVHLLPAPV FRMTADLQSR RRLGLTATLV REDGREGDVF SLIGPKRYDA PWKDIEAQGW
IAPADCVEVR VTLTDEERLQ YAVAENEEKY KLCSTAHTKV NVVKSILAKH AGSPTLVIGA
YIDQLEELGR ELDAPVIQGS TKNKEREALF DRFRSGELQT LVVSKVANFS IDLPEASVAV
QVSGTFGSRQ EEAQRLGRLL RPKKDGGQAH FYSVVSRDTL DADYAAHRQR FLAEQGYAYR
ITDADDLLGP AIGEESAG
//
