ID   H5WQC1_9BURK            Unreviewed;       339 AA.
AC   H5WQC1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Methionine synthase II (Cobalamin-independent) {ECO:0000313|EMBL:EHR71251.1};
GN   ORFNames=BurJ1DRAFT_2419 {ECO:0000313|EMBL:EHR71251.1};
OS   Burkholderiales bacterium JOSHI_001.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX   NCBI_TaxID=864051 {ECO:0000313|EMBL:EHR71251.1, ECO:0000313|Proteomes:UP000004674};
RN   [1] {ECO:0000313|EMBL:EHR71251.1, ECO:0000313|Proteomes:UP000004674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JOSHI_001 {ECO:0000313|EMBL:EHR71251.1,
RC   ECO:0000313|Proteomes:UP000004674};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Zeytun A., Lu M., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Smith J., Lewis G.,
RA   Woyke T.;
RT   "Noncontiguous Finished sequence of Burkholderiales bacterium JOSHI_001.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine synthase
CC       family. {ECO:0000256|ARBA:ARBA00009553}.
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DR   EMBL; CM001438; EHR71251.1; -; Genomic_DNA.
DR   AlphaFoldDB; H5WQC1; -.
DR   STRING; 864051.BurJ1DRAFT_2419; -.
DR   eggNOG; COG0620; Bacteria.
DR   HOGENOM; CLU_040013_3_0_4; -.
DR   OrthoDB; 244285at2; -.
DR   BioCyc; BBAC864051:G1H30-2418-MONOMER; -.
DR   Proteomes; UP000004674; Chromosome.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   CDD; cd03311; CIMS_C_terminal_like; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR   Pfam; PF01717; Meth_synt_2; 1.
DR   SUPFAM; SSF51726; UROD/MetE-like; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004674};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          3..331
FT                   /note="Cobalamin-independent methionine synthase MetE C-
FT                   terminal/archaeal"
FT                   /evidence="ECO:0000259|Pfam:PF01717"
SQ   SEQUENCE   339 AA;  37306 MW;  6D2913077D0DD7E6 CRC64;
     MFKTAIAGSL PKPAWLAETG KLWPRWQAEG PELAQAKLDA TLLWVKQQED AGLSVIGDGE
     QSRQHFVHGF LERVEGIDFE HKVEMGIRAD RYKAMVPQVV GPLKLAGRVH EAEARFVRAH
     TRRQVKFTLP GPMTIVDTVA DRFYGDREKL AMAFAELLNQ EALALQADGV DIVQFDEPAF
     NVYMDDAARW GVPALERAAQ GLGCKTAVHI CYGYGIQANL DWKGTLGQEW RQYEKVFPAL
     AASRIDQVSV ECIHSRVPAE LMALLTGKDV MVGVIDVASD SIETPEEVAD TIGRALQHVP
     RQHLVACTNC GLAPMQRAVA EAKLRALAQG AALAQQRYG
//