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Database: UniProt
Entry: H5WSW6_9BURK
LinkDB: H5WSW6_9BURK
Original site: H5WSW6_9BURK 
ID   H5WSW6_9BURK            Unreviewed;       502 AA.
AC   H5WSW6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-JUL-2017, entry version 37.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BurJ1DRAFT_0001 {ECO:0000313|EMBL:EHR68900.1};
OS   Burkholderiales bacterium JOSHI_001.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales.
OX   NCBI_TaxID=864051 {ECO:0000313|EMBL:EHR68900.1, ECO:0000313|Proteomes:UP000004674};
RN   [1] {ECO:0000313|EMBL:EHR68900.1, ECO:0000313|Proteomes:UP000004674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JOSHI_001 {ECO:0000313|EMBL:EHR68900.1,
RC   ECO:0000313|Proteomes:UP000004674};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Zeytun A., Lu M., Detter J.C., Han C.,
RA   Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I.,
RA   Smith J., Lewis G., Woyke T.;
RT   "Noncontiguous Finished sequence of Burkholderiales bacterium
RT   JOSHI_001.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CM001438; EHR68900.1; -; Genomic_DNA.
DR   RefSeq; WP_009548046.1; NZ_CM001438.1.
DR   EnsemblBacteria; EHR68900; EHR68900; BurJ1DRAFT_0001.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004674; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004674};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004674}.
FT   DOMAIN      199    333       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      410    479       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     207    214       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   502 AA;  54920 MW;  498B6F5B2FBD3FAB CRC64;
     MSLDLWSRGC ERLAAELPEQ QYNTWIRPLP PAEVQDLGEA GSVASLRVPN RFKLDWIRSQ
     YAGRIESLLS ELAGKPVRLE LSLAPREALA MGMPVRALVN GQASPASLAV PVPAPGVGGP
     RAAGSLLDAA LRNAEASRAN GGHAGAVQPS MAPLAPSAPP AANRHKLNTA LTFDNLVAGR
     ANQMARTAAL HVAGAPGVMY NPLFIYGGVG LGKTHLVHAV GNALLKDKPD ARVLYLHAEQ
     FISDVVKNYQ RKTFDELKAK YHNLDLLLID DVQFFAGKDR TQEEFFNAFE ALLAKRAHII
     MTSDTYPKGL VDIDERLTSR FDAGLTVAIE PPELEMRVAI LLAKARAEGA EMPEDVAFFV
     AKNVRANVRE LEGALRKVLA YSRFSQKDIN IALAREALKD LLSIQNRQVG VENIQKTVAD
     FYKIKVADMY SKKRPASIAR PRQIAMYLAK EMTQKSLPEI GELFGGRDHT TVLHAVRKIG
     GERSKDTELN QQLHVLEQTL KG
//
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