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Database: UniProt
Entry: H5WX49_9PSEU
LinkDB: H5WX49_9PSEU
Original site: H5WX49_9PSEU 
ID   H5WX49_9PSEU            Unreviewed;       547 AA.
AC   H5WX49;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-SEP-2017, entry version 38.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SacmaDRAFT_0002 {ECO:0000313|EMBL:EHR48323.1};
OS   Saccharomonospora marina XMU15.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharomonospora.
OX   NCBI_TaxID=882083 {ECO:0000313|EMBL:EHR48323.1, ECO:0000313|Proteomes:UP000004926};
RN   [1] {ECO:0000313|EMBL:EHR48323.1, ECO:0000313|Proteomes:UP000004926}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XMU15 {ECO:0000313|EMBL:EHR48323.1};
RX   PubMed=22768369; DOI=10.4056/sigs.2655905;
RA   Klenk H.P., Lu M., Lucas S., Lapidus A., Copeland A., Pitluck S.,
RA   Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G., Land M.,
RA   Ivanova N., Rohde M., Goker M., Detter J.C., Li W.J., Kyrpides N.C.,
RA   Woyke T.;
RT   "Genome sequence of the ocean sediment bacterium Saccharomonospora
RT   marina type strain (XMU15(T)).";
RL   Stand. Genomic Sci. 6:265-275(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CM001439; EHR48323.1; -; Genomic_DNA.
DR   RefSeq; WP_009151716.1; NZ_CM001439.1.
DR   EnsemblBacteria; EHR48323; EHR48323; SacmaDRAFT_0002.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004926; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004926};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004926}.
FT   DOMAIN      239    367       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      451    520       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     247    254       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   547 AA;  60944 MW;  47D43A3D8A88D50E CRC64;
     MSEHQLNLAV VWEQVVRELS DGTLSPQQRA WMRVTRPIGL LDGTALLAAP SDFAKEAIER
     ALREPITSAL SRRLGRDVSL AVKVDAADSA PPPSAPTRYG SAPTGLDTGS RPPGQRLPPT
     DDTLTVPVGR HARIDPTQQP LPPMQQLQHA QPPQPKPTEG EDGDEEVDEE GEALAAVHEI
     WPTFSGQPIA GQPYTAPAQP QTSKTRLNEK YTFDTFVIGA SNRFAHAAAV AVAEAPSRAY
     NPLFIWGESG LGKTHLLHAV GHYAQRLFPG MRVRYVSTEE FTNDFINSLR DDRKVAFQRR
     YRDIDILLVD DIQFLEGKEG TQEEFFHTFN TLHNSNKQIV VSSDRPPKRL ETLEDRLRTR
     FEWGLITDIQ PPELETRIAI LRKKAAQDRL AVPGEVLEFI AARIEANIRE LEGALIRVTA
     FASLNQQAVD VGLAEIVLRD LIPDSQAPEI SASTIMGVTA EFFDVTLEDL CGPGKTKALA
     TARQIAMYLC RELTDMSLPR IGQTFGGRDH TTVMHADKKI RKEMAERRRI YDQVQELTSR
     IKQRARQ
//
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