ID H5X1I5_9PSEU Unreviewed; 725 AA.
AC H5X1I5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Putative RND superfamily drug exporter {ECO:0000313|EMBL:EHR49776.1};
GN ORFNames=SacmaDRAFT_1500 {ECO:0000313|EMBL:EHR49776.1};
OS Saccharomonospora marina XMU15.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=882083 {ECO:0000313|EMBL:EHR49776.1, ECO:0000313|Proteomes:UP000004926};
RN [1] {ECO:0000313|EMBL:EHR49776.1, ECO:0000313|Proteomes:UP000004926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XMU15 {ECO:0000313|EMBL:EHR49776.1,
RC ECO:0000313|Proteomes:UP000004926};
RX PubMed=22768369; DOI=10.4056/sigs.2655905;
RA Klenk H.P., Lu M., Lucas S., Lapidus A., Copeland A., Pitluck S.,
RA Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G., Land M.,
RA Ivanova N., Rohde M., Goker M., Detter J.C., Li W.J., Kyrpides N.C.,
RA Woyke T.;
RT "Genome sequence of the ocean sediment bacterium Saccharomonospora marina
RT type strain (XMU15(T)).";
RL Stand. Genomic Sci. 6:265-275(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CM001439; EHR49776.1; -; Genomic_DNA.
DR RefSeq; WP_009153162.1; NZ_CM001439.1.
DR AlphaFoldDB; H5X1I5; -.
DR STRING; 882083.SacmaDRAFT_1500; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_1_1_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000004926; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004926};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..324
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 725 AA; 75307 MW; 2402954BBD16349D CRC64;
MATFLSRVGR FSFQRRWLVT GIWVVLLAAF GVGALTLSGQ TTNSVAIPGT ESQRAIEQLK
QKFPEAGVGG ATARVVMAAP QGEKLDPATV AEVVDGLRAA PKVAGVTDPF QARMVSPDGR
IALAQVTYQV KNFELTESDR EALRSAADPG RAEGLAVEFG GDAMQPMPQT QPTEGIGVAV
AAVVLIVTFG SLLAAGLPLL TALIGIGIGM AGITAASGFL ELNSNTPVLA LMIGLAVGID
YALFILSRYR HELRQGREPA DAAALAVGTA GSAVVFAGLT VIIALAGLTI VGIPVLGEMG
LAASVTVAVA VLIALTLLPA VLGFVRTKVL GGRIPGLRGG NGNGPTLGER WAALVARRRG
IVLVLSVAGL AVLAVPATDM RLGLPNDSTA PPDSTQHRAY NLISEGFGPG SNGPLVVMVE
AQTDPRAAVS AAARRISALD DVAAVTPPRF NAAGDTALLN VVPKSGPSSA ETEQLVTDIR
AEGQALHDRT GATVSVTGYT ALNIDVSRKM ADALLPYLSL IVGLAFILLM LVFRSVVVPL
KAAVGFLGSV AATFGAVVAV FQWGWLGDLL GVESTGPVMS MLPILLIGVL FGLAMDYQVF
LVTRMREEHV HGATPDQAMV IGFKHGSRVV VAAALIMISV FAGFVLAEET LIQSVGFALA
FGVAMDAFVV RMTIVPAVMS LLGKRAWWLP RWLDRVLPRV DVEGERLAAK PPEGGHGTDR
TLEPV
//
