ID H5X501_9PSEU Unreviewed; 592 AA.
AC H5X501;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EHR52280.1};
GN ORFNames=SacmaDRAFT_4085 {ECO:0000313|EMBL:EHR52280.1};
OS Saccharomonospora marina XMU15.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=882083 {ECO:0000313|EMBL:EHR52280.1, ECO:0000313|Proteomes:UP000004926};
RN [1] {ECO:0000313|EMBL:EHR52280.1, ECO:0000313|Proteomes:UP000004926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XMU15 {ECO:0000313|EMBL:EHR52280.1,
RC ECO:0000313|Proteomes:UP000004926};
RX PubMed=22768369; DOI=10.4056/sigs.2655905;
RA Klenk H.P., Lu M., Lucas S., Lapidus A., Copeland A., Pitluck S.,
RA Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G., Land M.,
RA Ivanova N., Rohde M., Goker M., Detter J.C., Li W.J., Kyrpides N.C.,
RA Woyke T.;
RT "Genome sequence of the ocean sediment bacterium Saccharomonospora marina
RT type strain (XMU15(T)).";
RL Stand. Genomic Sci. 6:265-275(2012).
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CM001439; EHR52280.1; -; Genomic_DNA.
DR RefSeq; WP_009155658.1; NZ_CM001439.1.
DR AlphaFoldDB; H5X501; -.
DR STRING; 882083.SacmaDRAFT_4085; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_21_0_11; -.
DR OrthoDB; 3229174at2; -.
DR Proteomes; UP000004926; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000004926}.
FT DOMAIN 8..185
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 188..284
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 314..492
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 495..591
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 592 AA; 63011 MW; B4D2A223F9E5142F CRC64;
MAREFSVVGV VGLGTMGSGI AEVLARSGVT VVAVEVDEHA AARGRGHIEH STARAAAKGK
LDEAARTELL ARIRYTTTLS DLADADLVIE AVPENLELKA DIFRRLDAIT RPDTVLASNT
SSLSVTEIGV HTQRPGKVVG THFFNPAPVL KLIEVVRTVV TEPDVVADVV NFVKALGKTP
VVIGDRAGFI ANALLFGYLN HAVRMYEQRY ATREDLDAAM RLGCGYPMGP LALLDLIGLD
TAYEILDTMY RQSRDKLHAP APLLKQMITA GLLGRKSGRG FYTYDAPDSP TVVTDAETPR
PAATGGGEAR EVTKVGVVGT GTMATGIVEV FAKRGYDVVL RARTGEKGEA ALQRLRGSLD
RSVAKGRMTA ADAEAVLERI RPVVDFADLA DADLIVEAVA EELPVKQAVF AALDKVAKPG
AVLATTTSSL PVIECAAATS RQGDVVGMHF FNPAPVMRLV EVVSTIATTP DIAATAHAVC
EAIGKHPVHC GDRAGFIVNA LLFPYLGDAV KMLEAHYAEA DDIDTAMKVG CRLPMGPFEL
LDVVGLDVSL AIQRTLFNEF REAGFAPAPL LEHLVTAGRL GRKTGKGFRD YT
//
