ID H5X540_9PSEU Unreviewed; 331 AA.
AC H5X540;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component alpha subunit {ECO:0000313|EMBL:EHR53372.1};
GN ORFNames=SacmaDRAFT_5211 {ECO:0000313|EMBL:EHR53372.1};
OS Saccharomonospora marina XMU15.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=882083 {ECO:0000313|EMBL:EHR53372.1, ECO:0000313|Proteomes:UP000004926};
RN [1] {ECO:0000313|EMBL:EHR53372.1, ECO:0000313|Proteomes:UP000004926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XMU15 {ECO:0000313|EMBL:EHR53372.1,
RC ECO:0000313|Proteomes:UP000004926};
RX PubMed=22768369; DOI=10.4056/sigs.2655905;
RA Klenk H.P., Lu M., Lucas S., Lapidus A., Copeland A., Pitluck S.,
RA Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G., Land M.,
RA Ivanova N., Rohde M., Goker M., Detter J.C., Li W.J., Kyrpides N.C.,
RA Woyke T.;
RT "Genome sequence of the ocean sediment bacterium Saccharomonospora marina
RT type strain (XMU15(T)).";
RL Stand. Genomic Sci. 6:265-275(2012).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CM001439; EHR53372.1; -; Genomic_DNA.
DR RefSeq; WP_009156748.1; NZ_CM001439.1.
DR AlphaFoldDB; H5X540; -.
DR STRING; 882083.SacmaDRAFT_5211; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_11; -.
DR OrthoDB; 9766715at2; -.
DR Proteomes; UP000004926; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:EHR53372.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004926}.
FT DOMAIN 24..320
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 331 AA; 34768 MW; AE0E749C099B8843 CRC64;
MTDTLSTAAT PELDENALLA AYRTMRTIRA FEERLHEEFA TGEIPGFVHL YAGEEASATG
VCSHLDERDS IASTHRGHGH CIAKGVDVLA MMAEIYGRST GSCHGKGGSM HIADLAKGML
GANGIVGGGP PLICGAALAA KQQRSGGVGV AFFGDGASNQ GTTLEALNLA SVWELPAIFV
AENNGYAEAT ASTWSVAADN IADRAAGFGM PGVIVDGFDF FAVYEAAGEA ISRAREGGGP
TLLEIKFTRY FGHFEGDQQS YRASEVAEAR AKLDCLKRFR ARVAETGQLE PARLNAVDAE
VSALIDTAVR EAKAAPKPTA ADLETDVYVS Y
//
