ID H5X7E8_9PSEU Unreviewed; 553 AA.
AC H5X7E8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase {ECO:0000313|EMBL:EHR50167.1};
GN ORFNames=SacmaDRAFT_1908 {ECO:0000313|EMBL:EHR50167.1};
OS Saccharomonospora marina XMU15.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=882083 {ECO:0000313|EMBL:EHR50167.1, ECO:0000313|Proteomes:UP000004926};
RN [1] {ECO:0000313|EMBL:EHR50167.1, ECO:0000313|Proteomes:UP000004926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XMU15 {ECO:0000313|EMBL:EHR50167.1,
RC ECO:0000313|Proteomes:UP000004926};
RX PubMed=22768369; DOI=10.4056/sigs.2655905;
RA Klenk H.P., Lu M., Lucas S., Lapidus A., Copeland A., Pitluck S.,
RA Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G., Land M.,
RA Ivanova N., Rohde M., Goker M., Detter J.C., Li W.J., Kyrpides N.C.,
RA Woyke T.;
RT "Genome sequence of the ocean sediment bacterium Saccharomonospora marina
RT type strain (XMU15(T)).";
RL Stand. Genomic Sci. 6:265-275(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CM001439; EHR50167.1; -; Genomic_DNA.
DR RefSeq; WP_009153552.1; NZ_CM001439.1.
DR AlphaFoldDB; H5X7E8; -.
DR STRING; 882083.SacmaDRAFT_1908; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_4_11; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000004926; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd00568; TPP_enzymes; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF169; ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:EHR50167.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004926};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 8..115
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 191..317
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 384..526
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
FT REGION 164..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 57143 MW; 421BBCE8A650CFB6 CRC64;
MTVPSYAQEL AIAVAKTGCT HVFGLMGDGN MQLFVALRRQ GVHVVEVRHE SAAVAMAEGY
GWSCDQVGIC SVTHGPGLSH VATSLLVAAR NRSPLVVIAA ETPAGYQGAQ TFDQQSFAEA
CETRYRRMTQ GERPAQALAD AIESARDVSG PVILGVAADL LASTVDDSPA PGEPPAPTPG
PPGLDDGAAA ERLTQLIAGS ARPVLIAGRG ATGGRSVGLL RTLAEHVGAG LATTLPAKGL
FDGHHLDLGI AGGLAHPAAE RVLRSADLVV GIGATMGRST TQSMRLFADA QVVTVVSDAR
GVAGVEPLLG DAVRTLEHTT ALARVATEPR EPWFHPVGPA AQCWAEDLRE FAPPIPDGTV
DPRRAVARIS EHIPDDANVV ISNGHCSGFA AAFVTAPARG RFFAAQGFGS IGQALPTAIG
VALGAPGRKT VVFEGDAAFM MHAQELDTAA RAGADLTVFV LNDQALGTEY QRLHLEGSDA
GAAVVPTPGL AALAGALGAR ATTIDTDTAY AHAEAALRPG LAFVDVRTAR SVLSRHLRLP
YRRVDPPQQV RSS
//