ID H5XWQ6_9FIRM Unreviewed; 815 AA.
AC H5XWQ6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=CRISPR-associated helicase Cas3/CRISPR-associated endonuclease Cas3-HD {ECO:0000313|EMBL:EHQ90705.1};
GN ORFNames=DesyoDRAFT_3713 {ECO:0000313|EMBL:EHQ90705.1};
OS Desulfosporosinus youngiae DSM 17734.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC Desulfosporosinus.
OX NCBI_TaxID=768710 {ECO:0000313|EMBL:EHQ90705.1, ECO:0000313|Proteomes:UP000005104};
RN [1] {ECO:0000313|EMBL:EHQ90705.1, ECO:0000313|Proteomes:UP000005104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17734 {ECO:0000313|EMBL:EHQ90705.1,
RC ECO:0000313|Proteomes:UP000005104};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Lu M., Land M.L., Hauser L., Pester M.,
RA Spring S., Ollivier B., Rattei T., Klenk H.-P., Wagner M., Loy A.,
RA Woyke T.J.;
RT "The Noncontiguous Finished genome of Desulfosporosinus youngiae DSM
RT 17734.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CM001441; EHQ90705.1; -; Genomic_DNA.
DR RefSeq; WP_007785243.1; NZ_CM001441.1.
DR AlphaFoldDB; H5XWQ6; -.
DR STRING; 768710.DesyoDRAFT_3713; -.
DR eggNOG; COG1203; Bacteria.
DR HOGENOM; CLU_010123_0_0_9; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000005104; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000313|EMBL:EHQ90705.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005104}.
FT DOMAIN 15..208
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 279..457
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 815 AA; 91570 MW; 47821851CD5C4BD0 CRC64;
MHTNSKRFIA HIRAADKQEQ YVDEHNDHVA DLAAAMAQSY GLANIAKFAG RHHDDGKNTP
EFAAYIRAAA EGKKVVRGSV IHSTHGAMLV NELASSKLSP RLTAEMVRTA IMSHHGLRDC
LSLDGDAVFA EAAEKVADSY KSVKEVVYHC YGGDLINQEF ADACLDIRAM IKSIKSLTKQ
DKSLGSFQFY LAMFTRLLTS FVIDADRTDT ACFEDKRALP QPKALDERRA MWETYLAHYE
KELEELTKGK KPSSLDPYRG EISRSCAEFD GGEAGIFRLV VPCGAGKTLA ALRYALHTAR
DYGKERIFYV APFNSILEQN AAEISRFIGD PDAVLEHHSN IIFNDNESND KKEEEKRYQL
LTENWAQSPV VATTAVQFLN TLFGGKTSNL RRMQALGNSV IILDEIQALP IKVLKLFNGA
MNFLATFCKT SVVLCSATQP LLDEVDKYQI LPPKSIIADE EKYIKAFRRV KIVDCMTERG
YSREDAADFI AGQLAEARSV LAIVNTKRGA REIFKQIRNR LADETPCRIV HLSTNMCPAH
RSRVLRQLRA GLEDKESGEK MICISTSLIE AGVDVSFERV VRSLTGLDNI VQAAGRCNRN
YETACGIVSI INLRDEQTGR LGYLKEARQA TQELLYSIKT SPGRYPGGAL SKAAMKEYYA
RYFYSLFAEM AYPLKFDPEH NLLHLLTSNP SGQRGFEEKY PQERLPDLKQ AFREAGKAFS
VIEDDGKVDV FIDYDHEAGN RLQKLKAATT LQEKRSALRQ LQPYMVQLRE NDWIQRQRLA
LTLEDAGILV LPPGYYDGEY GVDETLDIKM ETLIF
//
