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Database: UniProt
Entry: H5Y499_9FIRM
LinkDB: H5Y499_9FIRM
Original site: H5Y499_9FIRM 
ID   H5Y499_9FIRM            Unreviewed;       181 AA.
AC   H5Y499;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Signal peptidase I {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
DE            EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208, ECO:0000256|RuleBase:RU362042};
GN   ORFNames=DesyoDRAFT_2879 {ECO:0000313|EMBL:EHQ89927.1};
OS   Desulfosporosinus youngiae DSM 17734.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC   Desulfosporosinus.
OX   NCBI_TaxID=768710 {ECO:0000313|EMBL:EHQ89927.1, ECO:0000313|Proteomes:UP000005104};
RN   [1] {ECO:0000313|EMBL:EHQ89927.1, ECO:0000313|Proteomes:UP000005104}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17734 {ECO:0000313|EMBL:EHQ89927.1,
RC   ECO:0000313|Proteomes:UP000005104};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Lu M., Land M.L., Hauser L., Pester M.,
RA   Spring S., Ollivier B., Rattei T., Klenk H.-P., Wagner M., Loy A.,
RA   Woyke T.J.;
RT   "The Noncontiguous Finished genome of Desulfosporosinus youngiae DSM
RT   17734.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC         from secreted and periplasmic proteins.; EC=3.4.21.89;
CC         Evidence={ECO:0000256|ARBA:ARBA00000677,
CC         ECO:0000256|RuleBase:RU362042};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC       Membrane {ECO:0000256|RuleBase:RU362042}; Single-pass type II membrane
CC       protein {ECO:0000256|RuleBase:RU362042}.
CC   -!- SIMILARITY: Belongs to the peptidase S26 family.
CC       {ECO:0000256|ARBA:ARBA00009370, ECO:0000256|RuleBase:RU362042}.
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DR   EMBL; CM001441; EHQ89927.1; -; Genomic_DNA.
DR   RefSeq; WP_007784081.1; NZ_CM001441.1.
DR   AlphaFoldDB; H5Y499; -.
DR   STRING; 768710.DesyoDRAFT_2879; -.
DR   eggNOG; COG0681; Bacteria.
DR   HOGENOM; CLU_028723_5_1_9; -.
DR   OrthoDB; 9802919at2; -.
DR   Proteomes; UP000005104; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   CDD; cd06530; S26_SPase_I; 1.
DR   Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR   InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR   InterPro; IPR019533; Peptidase_S26.
DR   NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR   PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR   PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR   Pfam; PF10502; Peptidase_S26; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR   PROSITE; PS00761; SPASE_I_3; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU362042};
KW   Membrane {ECO:0000256|RuleBase:RU362042};
KW   Protease {ECO:0000256|RuleBase:RU362042};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005104};
KW   Transmembrane {ECO:0000256|RuleBase:RU362042};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362042}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362042"
FT   DOMAIN          15..171
FT                   /note="Peptidase S26"
FT                   /evidence="ECO:0000259|Pfam:PF10502"
FT   ACT_SITE        45
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT   ACT_SITE        91
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ   SEQUENCE   181 AA;  20765 MW;  6224B43BF8D86309 CRC64;
     MESSEKPKSS VRFLIELIEI VLIAFALSWV LRTYVIEARK IPTGSMLPTI QLEDRVIVDK
     FFFKRFDHIS PGDIIVFHPP PSAHATDDYI KRVVGLAGDT VEIKNNKTYV NGQPLYEPYL
     FETTMNDFSM TVVPNDYVFV MGDNRNNSAD SREWGFLPVE NITGRTLFRY WPIDQIGALA
     R
//
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