ID H6BLE5_EXODN Unreviewed; 360 AA.
AC H6BLE5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit {ECO:0000256|ARBA:ARBA00014912};
GN ORFNames=HMPREF1120_01045 {ECO:0000313|EMBL:EHY52838.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY52838.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY52838.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY52838.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000256|ARBA:ARBA00008638}.
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DR EMBL; JH226130; EHY52838.1; -; Genomic_DNA.
DR RefSeq; XP_009153299.1; XM_009155051.1.
DR AlphaFoldDB; H6BLE5; -.
DR STRING; 858893.H6BLE5; -.
DR GeneID; 20305684; -.
DR VEuPathDB; FungiDB:HMPREF1120_01045; -.
DR eggNOG; KOG0794; Eukaryota.
DR HOGENOM; CLU_034754_2_0_1; -.
DR InParanoid; H6BLE5; -.
DR OMA; KVAHSQF; -.
DR OrthoDB; 102875at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF7; CYCLIN-C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF028758; Cyclin, C/H/G types; 2.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 53..142
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 264..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 40734 MW; 59C7E58FC00C5394 CRC64;
MAADYWTSTQ RTYWTFTPEK LSSIRDDLER ANAKTIEQFP FPDRRLMFIF LRDRLLQLGK
RLPFRQQCMA TALVYLHRYF LSTPMQNVNI YLLVATAFYL SSKTEESPHH IRLVAAEARQ
AWPELMPGDV FRLGEMEFCL ISEMRSQLIV WHPYRTLIAL KENQDLRLTN DELGLAWSII
NDSYMTDLPL TCPPHLIAII AMLLAVVFLP TAKASGTLRP ISHESLVNPD SSAGPFSSLV
GRHGQNLSGS FSAAVGNLQM SNNNQQFGQH SVNNNQGKSR AAQESSTTDR DKDKTIVAAI
KDSEKLQNII TFLVESGIDV EQVINGIQEM ISLYSVWEEY NEKTVREAVA RCIKGRGLDG
//
