ID   H6BQL9_EXODN            Unreviewed;       345 AA.
AC   H6BQL9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Isoflavone reductase (CipA) {ECO:0000313|EMBL:EHY53836.1};
GN   ORFNames=HMPREF1120_02017 {ECO:0000313|EMBL:EHY53836.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY53836.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY53836.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY53836.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NmrA-type oxidoreductase family. Isoflavone
CC       reductase subfamily. {ECO:0000256|ARBA:ARBA00005725}.
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DR   EMBL; JH226131; EHY53836.1; -; Genomic_DNA.
DR   RefSeq; XP_009154297.1; XM_009156049.1.
DR   AlphaFoldDB; H6BQL9; -.
DR   STRING; 858893.H6BQL9; -.
DR   GeneID; 20306656; -.
DR   VEuPathDB; FungiDB:HMPREF1120_02017; -.
DR   eggNOG; ENOG502QTQ8; Eukaryota.
DR   HOGENOM; CLU_044876_1_1_1; -.
DR   InParanoid; H6BQL9; -.
DR   OMA; PEYAKNQ; -.
DR   OrthoDB; 2166478at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd05259; PCBER_SDR_a; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR045312; PCBER-like.
DR   PANTHER; PTHR47706:SF7; NMRA-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47706; NMRA-LIKE FAMILY PROTEIN; 1.
DR   Pfam; PF13460; NAD_binding_10; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT   DOMAIN          25..113
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF13460"
SQ   SEQUENCE   345 AA;  38326 MW;  65CB009EF7BADB38 CRC64;
     MAGVKYAKDQ PAGFKNHVEN IAIVGASGHI GAFIAHELLK TKIHKVTALT RAENNNTNKF
     PPGLSIIPVN YSDPSTLVNA LRGQDVLIIT MSAFAPRDTE AKLIQAAADA GVPWVMPNEW
     GLDGQSTDLV REAMTGPGRE AARNLIASLG KSSFVSLVCG FWYEFSLAGQ EIRFGFDFPN
     RTVTFYDDGQ TKINVSTWAQ CGRAVARLWS LKIMPDDEKD TSPTVSTHFR NGFVYISSFL
     LSQRDMFESV LRVTGTTEQD WKIQYQDVKQ RYREGLAAFQ NAGDMMAWVK AMYARDFWPD
     GSGNYQAVRG LHNRLLGLPD EDLDERTKVA IDMVENGDDA CRPKD
//