ID   H6BRB6_EXODN            Unreviewed;       556 AA.
AC   H6BRB6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   SubName: Full=Phytoene dehydrogenase {ECO:0000313|EMBL:EHY54697.1};
GN   ORFNames=HMPREF1120_02862 {ECO:0000313|EMBL:EHY54697.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY54697.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY54697.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY54697.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Carotenoid biosynthesis. {ECO:0000256|ARBA:ARBA00004829,
CC       ECO:0000256|RuleBase:RU362075}.
CC   -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC       {ECO:0000256|RuleBase:RU362075}.
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DR   EMBL; JH226131; EHY54697.1; -; Genomic_DNA.
DR   RefSeq; XP_009155158.1; XM_009156910.1.
DR   AlphaFoldDB; H6BRB6; -.
DR   STRING; 858893.H6BRB6; -.
DR   GeneID; 20307501; -.
DR   VEuPathDB; FungiDB:HMPREF1120_02862; -.
DR   eggNOG; KOG4254; Eukaryota.
DR   HOGENOM; CLU_019722_2_1_1; -.
DR   InParanoid; H6BRB6; -.
DR   OMA; INYPKGG; -.
DR   OrthoDB; 5490570at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR014105; Carotenoid/retinoid_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   NCBIfam; TIGR02734; crtI_fam; 1.
DR   PANTHER; PTHR43734; PHYTOENE DESATURASE; 1.
DR   PANTHER; PTHR43734:SF1; PHYTOENE DESATURASE; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   Carotenoid biosynthesis {ECO:0000256|ARBA:ARBA00022746,
KW   ECO:0000256|RuleBase:RU362075}; Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU362075};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        538..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          15..298
FT                   /note="Amine oxidase"
FT                   /evidence="ECO:0000259|Pfam:PF01593"
SQ   SEQUENCE   556 AA;  61984 MW;  99136621C120CBB3 CRC64;
     MSKPKSVVII GAGAGGIASA ARLAKAGFRV TVLEKNEFTG GRCSLIHDDG YRFDQGPSLL
     LLPDLFRETF ADLDTSLEEE GVELFKCEPN YNVWFRDGEC IELSTDTAKM KKTIERWEGK
     EGFEQYLAWM REAHVHYEAS VTHVLKKNFS NMLAMVRPSF LPYLLALHPF DSIWNRAAQY
     FKTERLRRAF TFGSMYMGMS PFDAPGTYSL LQYTELAEGI WYPKGGFHKV LDALVKVGER
     LGVEYRLATP VSHVNIDRHS KRASGVTLAS GEIVNADIVL VNADLVYAYN HLLPPSPRAS
     ALSSKPASCS SISFYWSMDT IIPELHTHNV FLAEDYKDSF DDIFKRQQIP KEPSFYVNVP
     SRVDPSAAPA GRDSVVVLVP CGHLLEGKAD RGLDPQNAQD WEAMVSKART AVFETVRLRT
     GADLLSHVKH EIINTPASWK ESFNLDKGAI LGLSHSFFNV LSFRPGTKHT EFRDLYFVGA
     STHPGTGVPI VLAGSKLTTG QILDDLGMTK PWSEGGHKRR IVSELDQRGK TPLDLARVMY
     LLVFALAVIL YLLALR
//