ID H6BWK6_EXODN Unreviewed; 620 AA.
AC H6BWK6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=NAD-dependent histone deacetylase SIR2 {ECO:0000313|EMBL:EHY56067.1};
GN ORFNames=HMPREF1120_04171 {ECO:0000313|EMBL:EHY56067.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY56067.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY56067.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY56067.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
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DR EMBL; JH226132; EHY56067.1; -; Genomic_DNA.
DR RefSeq; XP_009156528.1; XM_009158280.1.
DR AlphaFoldDB; H6BWK6; -.
DR STRING; 858893.H6BWK6; -.
DR GeneID; 20308810; -.
DR VEuPathDB; FungiDB:HMPREF1120_04171; -.
DR eggNOG; KOG2671; Eukaryota.
DR HOGENOM; CLU_029646_3_0_1; -.
DR InParanoid; H6BWK6; -.
DR OMA; CWSHERS; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 307..445
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
FT REGION 61..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 68669 MW; 96F01331DF348F2E CRC64;
MDTKMDTDYL IRLAQAHESF RRPELEALSS LANLPCKIVE YAENSPFCIV RFDFPSTSSS
PLLPLSQTPP SPSSAPSAPS LPSASAKPTK TTSASLDDSV PSSIQNGTTA HDHDHHSKHT
TNNVRTAIDQ RVRAFEARSI LSKGIYEIWG QGTNYDELHR DVAKRSRHLW ELYKHHSFKF
VIDCYGSSQD AEQQRRIINS FSYLGLEGDI KMKNPDVEFC VMEEWLPLDH TTDQPTDQPT
DQTTTSPTDQ SQTETTTTTT ITTTTTTNNN TERLIDRVAR TTRRRVLLTR KIGTSQRWLR
EKHDLKKRPY ISTTSMDAEL ALVTANIALA SPGKIFLDPF VGTGGFMVAA AELGAWVLGS
DIDGRSYRGK GTGLDKGVGA NFKKYGLTHL FGDCISSDLT NTPFRKSSSR SQSQSQQQQP
TKNNGGGGRW LDGIVCDPPY GVREGLKVLG ARPRKSVVAA AAAAENGAEV TSSDASAAPK
EIFVDGVPAH KLPGYVAPKK PYSFSKMLDD ILDFAADTLV DGGRLAFWMP SVNENEAGEE
EVTVIPQHPL LELKHECVQR FNRWSRRLLV YERRPDSVGL PCRQEKVVDV NGTGTSTGHT
ADELNPFRRR YFQPFMVDRS
//
