ID   H6BYN7_EXODN            Unreviewed;       611 AA.
AC   H6BYN7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=D-lactate dehydrogenase (Cytochrome) {ECO:0000313|EMBL:EHY56750.1};
GN   ORFNames=HMPREF1120_04817 {ECO:0000313|EMBL:EHY56750.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY56750.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY56750.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY56750.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; JH226133; EHY56750.1; -; Genomic_DNA.
DR   RefSeq; XP_009157211.1; XM_009158963.1.
DR   AlphaFoldDB; H6BYN7; -.
DR   STRING; 858893.H6BYN7; -.
DR   GeneID; 20309456; -.
DR   VEuPathDB; FungiDB:HMPREF1120_04817; -.
DR   eggNOG; KOG1231; Eukaryota.
DR   HOGENOM; CLU_017779_3_1_1; -.
DR   InParanoid; H6BYN7; -.
DR   OMA; GQGFEWA; -.
DR   OrthoDB; 1664005at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.30.70.2740; -; 1.
DR   InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR   InterPro; IPR016166; FAD-bd_PCMH.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR   InterPro; IPR006094; Oxid_FAD_bind_N.
DR   InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR   PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11748:SF116; D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560); 1.
DR   Pfam; PF02913; FAD-oxidase_C; 1.
DR   Pfam; PF01565; FAD_binding_4; 1.
DR   SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR   SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR   PROSITE; PS51387; FAD_PCMH; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        100..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          185..362
FT                   /note="FAD-binding PCMH-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51387"
SQ   SEQUENCE   611 AA;  67074 MW;  E4A69F25D6F5C354 CRC64;
     MKSIARCARL AASVVSSLER LSHPQSPSPS LLLRQISGLR TFHSSPTRLQ EKNKLPEKDS
     LSFRGQLYES TADRLKRERE SEARYIQATR TRRAGEGRSL ALSIVILSVA GAGYWLGSRG
     EKALDTSSTT PLSRAHPPQL DTRTSVLQAA WVDFAQIVGK DNVSTVPDDL EAHSGSEWSS
     YTTKPNERPF AIVYPASTEE VSQIMQVCHK RKIPVTAISG GTSLEGHFAP TRGGICIDMG
     RMDKILQFHP EDLDIIVQPA LGWEDLNEYL KGHGMFFPPD PGPGAKIGGM VGTGCSGTNA
     YRYGTMREWV ISLTVVLADG TVIKTRRRPR KSSAGYNLTQ MFIGSEGTLG IVTEATLKVT
     VLPKCQSVAV ATFPSIHAAA ECVAKVVGDG IQLAGIEILD DVQMKCINKS GMTSRQWQEA
     PTLFFKFAGT PDGIKEQIRT VQKMAKGTKN KSFEFARNDD EALELWSARK EALWSVMAMR
     RDETDHVWTT DVAVPISRLA DIIQETRDDI ANSGLLAGIC GHVGDGNFHT ILLYNDAEKQ
     VAEDVVHRMI RRAIAMDGTV TGEHGVGLKK REYIREELGD DTVDAMRRLK QAFDPLGLLN
     CDKIVQLEAG H
//