ID H6C1C4_EXODN Unreviewed; 568 AA.
AC H6C1C4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=ENTH domain-containing protein {ECO:0000259|PROSITE:PS50942};
GN ORFNames=HMPREF1120_05736 {ECO:0000313|EMBL:EHY57709.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY57709.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY57709.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY57709.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the epsin family.
CC {ECO:0000256|ARBA:ARBA00010130}.
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DR EMBL; JH226134; EHY57709.1; -; Genomic_DNA.
DR RefSeq; XP_009158170.1; XM_009159922.1.
DR AlphaFoldDB; H6C1C4; -.
DR STRING; 858893.H6C1C4; -.
DR GeneID; 20310375; -.
DR VEuPathDB; FungiDB:HMPREF1120_05736; -.
DR eggNOG; KOG2056; Eukaryota.
DR HOGENOM; CLU_012678_0_0_1; -.
DR InParanoid; H6C1C4; -.
DR OMA; STEFYDI; -.
DR OrthoDB; 1532at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR CDD; cd16991; ENTH_Ent1_Ent2; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.140.100; -; 1.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR12276; EPSIN/ENT-RELATED; 1.
DR PANTHER; PTHR12276:SF110; FI19443P1; 1.
DR Pfam; PF01417; ENTH; 1.
DR Pfam; PF02809; UIM; 2.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00726; UIM; 2.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50330; UIM; 2.
PE 3: Inferred from homology;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT DOMAIN 10..143
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 160..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 62421 MW; A70375B3688B6683 CRC64;
MSKVVRSVKN VTKGYSSVQI KVRNATSNDP WGPTGTDMAE IAALTFNNPS DFYEIMDMLD
KRLNDKGKNW RHVLKSLKVL DYCLHEGSEL VVTWARKNIY IIKTLREFQY VDEDGRDVGQ
NVRTTAKELT SLILDEDRLR SERSDRKLWK ARVSGLDEYA PQAIAGPSQR PRRQTRSGAD
DDDPELRRAL ELSKMEADQE ARDRSRHTAS ENDEQDPELR RAIQLSKEEA DLRARQLEDQ
NAASLFDDTP VPAQSQPTGF NQGYQQQPAV DWFGNPLQQQ PQSTGFLSNQ YAQPQQTGFQ
PGYTGAFQSS QPTGYDQFGQ QPFLQQQNTL QPQQTAFPTN NPYGMQTGTD LFGAQSPQQA
GLQPGTNNPF SASSPQPLDA MKPLPTGSNN PFAQRTQQAS PSPFARATSQ PALGTLFESQ
PTSQFSQPTQ PNPILNYSSP QPSFQQQQQA QKPVNPQHAK LNALLASGEG QDTFGNTGDL
RIPAQHTAPG TFVNSAGQGL DRLRAAQTGT NPFFSAQATG FAQNQPGFGQ QAPAQTGPAG
GFGGFTQQNN NPFGQRPGAQ QSGSLIDL
//
